Author Correction: Cryo-EM structure and biochemical analysis reveal the basis of the functional difference between human PI3KC3-C1 and -C2.

Abstract:

:An amendment to this paper has been published and can be accessed via a link at the top of the paper.

journal_name

Cell Res

journal_title

Cell research

authors

Ma M,Liu JJ,Li Y,Huang Y,Ta N,Chen Y,Fu H,Ye MD,Ding Y,Huang W,Wang J,Dong MQ,Yu L,Wang HW

doi

10.1038/s41422-020-0311-z

subject

Has Abstract

pub_date

2020-06-01 00:00:00

pages

551-552

issue

6

eissn

1001-0602

issn

1748-7838

pii

10.1038/s41422-020-0311-z

journal_volume

30

pub_type

已发布勘误
  • Modifications and functional genomics of human transfer RNA.

    abstract::Transfer RNA (tRNA) is present at tens of millions of transcripts in a human cell and is the most abundant RNA in moles among all cellular RNAs. tRNA is also the most extensively modified RNA with, on an average, 13 modifications per molecule. The primary function of tRNA as the adaptor of amino acids and the genetic ...

    journal_title:Cell research

    pub_type: 杂志文章,评审

    doi:10.1038/s41422-018-0013-y

    authors: Pan T

    更新日期:2018-04-01 00:00:00

  • Inflammasomes: Intracellular detection of extracellular bacteria.

    abstract::The non-canonical inflammasome triggers host cell death and inflammation upon recognition of cytosolic LPS. A recent report in Cell now shows that Outer Membrane Vesicles (OMVs) of extracellular Gram-negative bacteria can deliver LPS into the host cell cytosol. ...

    journal_title:Cell research

    pub_type: 评论,杂志文章

    doi:10.1038/cr.2016.67

    authors: Broz P

    更新日期:2016-08-01 00:00:00

  • The human TTAGGG repeat factors 1 and 2 bind to a subset of interstitial telomeric sequences and satellite repeats.

    abstract::The study of the proteins that bind to telomeric DNA in mammals has provided a deep understanding of the mechanisms involved in chromosome-end protection. However, very little is known on the binding of these proteins to nontelomeric DNA sequences. The TTAGGG DNA repeat proteins 1 and 2 (TRF1 and TRF2) bind to mammali...

    journal_title:Cell research

    pub_type: 杂志文章

    doi:10.1038/cr.2011.40

    authors: Simonet T,Zaragosi LE,Philippe C,Lebrigand K,Schouteden C,Augereau A,Bauwens S,Ye J,Santagostino M,Giulotto E,Magdinier F,Horard B,Barbry P,Waldmann R,Gilson E

    更新日期:2011-07-01 00:00:00

  • Skeletal muscle mitochondrial remodeling in exercise and diseases.

    abstract::Skeletal muscle fitness and plasticity is an important determinant of human health and disease. Mitochondria are essential for maintaining skeletal muscle energy homeostasis by adaptive re-programming to meet the demands imposed by a myriad of physiologic or pathophysiological stresses. Skeletal muscle mitochondrial d...

    journal_title:Cell research

    pub_type: 杂志文章,评审

    doi:10.1038/s41422-018-0078-7

    authors: Gan Z,Fu T,Kelly DP,Vega RB

    更新日期:2018-10-01 00:00:00

  • Rbpj links uterine transformation and embryo orientation.

    abstract::Implantation involves complex signaling networks, which direct morphological and molecular transformation of the embryo and the uterus and establish the trajectory of normal pregnancy. The recent work by Zhang et al. published in Cell Research, identifies the transcriptional regulator, Rbpj, as essential for uterine c...

    journal_title:Cell research

    pub_type: 评论,杂志文章

    doi:10.1038/cr.2014.110

    authors: Robinson JF,Fisher SJ

    更新日期:2014-09-01 00:00:00

  • Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase.

    abstract::DNA methylation and demethylation regulate many crucial biological processes in mammals and are linked to many diseases. Active DNA demethylation is believed to be catalyzed by TET proteins and a putative DNA decarboxylase that may share some similarities in sequence, structure and catalytic mechanism with isoorotate ...

    journal_title:Cell research

    pub_type: 杂志文章

    doi:10.1038/cr.2013.107

    authors: Xu S,Li W,Zhu J,Wang R,Li Z,Xu GL,Ding J

    更新日期:2013-11-01 00:00:00

  • MLKL forms cation channels.

    abstract::The mixed lineage kinase domain-like (MLKL) protein is a key factor in tumor necrosis factor-induced necroptosis. Recent studies on necroptosis execution revealed a commitment role of MLKL in membrane disruption. However, our knowledge of how MLKL functions on membrane remains very limited. Here we demonstrate that ML...

    journal_title:Cell research

    pub_type: 杂志文章

    doi:10.1038/cr.2016.26

    authors: Xia B,Fang S,Chen X,Hu H,Chen P,Wang H,Gao Z

    更新日期:2016-05-01 00:00:00

  • Cell polarity protein Par3 complexes with DNA-PK via Ku70 and regulates DNA double-strand break repair.

    abstract::The partitioning-defective 3 (Par3), a key component in the conserved Par3/Par6/aPKC complex, plays fundamental roles in cell polarity. Herein we report the identification of Ku70 and Ku80 as novel Par3-interacting proteins through an in vitro binding assay followed by liquid chromatography-tandem mass spectrometry. K...

    journal_title:Cell research

    pub_type: 杂志文章

    doi:10.1038/sj.cr.7310145

    authors: Fang L,Wang Y,Du D,Yang G,Tak Kwok T,Kai Kong S,Chen B,Chen DJ,Chen Z

    更新日期:2007-02-01 00:00:00

  • NOPO modulates Egr-induced JNK-independent cell death in Drosophila.

    abstract::Tumor necrosis factor (TNF) family ligands play essential roles in regulating a variety of cellular processes including proliferation, differentiation and survival. Expression of Drosophila TNF ortholog Eiger (Egr) induces JNK-dependent cell death, while the roles of caspases in this process remain elusive. To further...

    journal_title:Cell research

    pub_type: 杂志文章

    doi:10.1038/cr.2011.135

    authors: Ma X,Huang J,Yang L,Yang Y,Li W,Xue L

    更新日期:2012-02-01 00:00:00

  • Identification of ABA-responsive genes in rice shoots via cDNA macroar-.

    abstract::Phytohormone abscisic acid (ABA) was critical for many plant growth and developmental processes including seed maturation, germination and response to environmental factors. With the purpose to detect the possible ABA related signal transduction pathways, we tried to isolate ABA-regulated genes through cDNA macroarray...

    journal_title:Cell research

    pub_type: 杂志文章

    doi:10.1038/sj.cr.7290151

    authors: Lin F,Xu SL,Ni WM,Chu ZQ,Xu ZH,Xue HW

    更新日期:2003-02-01 00:00:00

  • The IkappaB kinase - a bridge between inflammation and cancer.

    abstract::A potential link between inflammation and cancer has been suspected for over a century, but the exact molecular mechanisms connecting the two remained nebulous. We proposed that NF-kappaB transcription factors regulated via the IkappaB kinase (IKK) complex play a critical role in coupling inflammation and cancer and h...

    journal_title:Cell research

    pub_type: 杂志文章,评审

    doi:10.1038/cr.2008.30

    authors: Karin M

    更新日期:2008-03-01 00:00:00

  • MRG-1 is required for genomic integrity in Caenorhabditis elegans germ cells.

    abstract::During meiotic cell division, proper chromosome synapsis and accurate repair of DNA double strand breaks (DSBs) are required to maintain genomic integrity, loss of which leads to apoptosis or meiotic defects. The mechanisms underlying meiotic chromosome synapsis, DSB repair and apoptosis are not fully understood. Here...

    journal_title:Cell research

    pub_type: 杂志文章

    doi:10.1038/cr.2012.2

    authors: Xu J,Sun X,Jing Y,Wang M,Liu K,Jian Y,Yang M,Cheng Z,Yang C

    更新日期:2012-05-01 00:00:00

  • tsRNAs: new players in mammalian retrotransposon control.

    abstract::A recent study led by Professor Rob Martienssen in Cell showed that 3'-tRNA-derived small RNAs can suppress long terminal repeat retrotransposon activity in mammalian cells by mechanisms independent of DNA-associated epigenetic marks, suggesting how the genome may defend itself from retrotransposon invasion during epi...

    journal_title:Cell research

    pub_type: 评论,杂志文章

    doi:10.1038/cr.2017.109

    authors: Zhang Y,Shi J,Chen Q

    更新日期:2017-11-01 00:00:00

  • Competition between human cells by entosis.

    abstract::Human carcinomas are comprised of complex mixtures of tumor cells that are known to compete indirectly for nutrients and growth factors. Whether tumor cells could also compete directly, for example by elimination of rivals, is not known. Here we show that human cells can directly compete by a mechanism of engulfment c...

    journal_title:Cell research

    pub_type: 杂志文章

    doi:10.1038/cr.2014.138

    authors: Sun Q,Luo T,Ren Y,Florey O,Shirasawa S,Sasazuki T,Robinson DN,Overholtzer M

    更新日期:2014-11-01 00:00:00

  • Understanding biological functions through molecular networks.

    abstract::The completion of genome sequences and subsequent high-throughput mapping of molecular networks have allowed us to study biology from the network perspective. Experimental, statistical and mathematical modeling approaches have been employed to study the structure, function and dynamics of molecular networks, and begin...

    journal_title:Cell research

    pub_type: 杂志文章,评审

    doi:10.1038/cr.2008.16

    authors: Han JD

    更新日期:2008-02-01 00:00:00

  • Cellular localization and biochemical characterization of a novel calcium-dependent protein kinase from tobacco.

    abstract::By screening tobacco cDNA library with MCK1 as a probe, we isolated a cDNA clone NtCPK5 (accession number AY971376), which encodes a typical calcium-dependent protein kinase. Sequence analyses indicated that NtCPK5 is related to both CPKs and CRKs superfamilies and has all of the three conserved domains of CPKs. The b...

    journal_title:Cell research

    pub_type: 杂志文章

    doi:10.1038/sj.cr.7290330

    authors: Wang Y,Zhang M,Ke K,Lu YT

    更新日期:2005-08-01 00:00:00

  • MSM and HIV/AIDS in China.

    abstract::This article profiles current status of spread and control of HIV/AIDS in China. China has a significant population of MSM (men who have sex with men) and they have been becoming very much alive in many ways since 1990s due to recent social changes. Some surveys indicate that great many of MSM are engaged in high-risk...

    journal_title:Cell research

    pub_type: 杂志文章,评审

    doi:10.1038/sj.cr.7290359

    authors: Zhang BC,Chu QS

    更新日期:2005-11-01 00:00:00

  • LsrR-binding site recognition and regulatory characteristics in Escherichia coli AI-2 quorum sensing.

    abstract::In quorum sensing (QS) process, bacteria regulate gene expression by utilizing small signaling molecules called autoinducers in response to a variety of environmental cues. Autoinducer 2 (AI-2), a QS signaling molecule proposed to be involved in interspecies communication, is produced by many species of gram-negative ...

    journal_title:Cell research

    pub_type: 杂志文章

    doi:10.1038/cr.2009.91

    authors: Xue T,Zhao L,Sun H,Zhou X,Sun B

    更新日期:2009-11-01 00:00:00

  • Precise in vivo genome editing via single homology arm donor mediated intron-targeting gene integration for genetic disease correction.

    abstract::In vivo genome editing represents a powerful strategy for both understanding basic biology and treating inherited diseases. However, it remains a challenge to develop universal and efficient in vivo genome-editing tools for tissues that comprise diverse cell types in either a dividing or non-dividing state. Here, we d...

    journal_title:Cell research

    pub_type: 杂志文章

    doi:10.1038/s41422-019-0213-0

    authors: Suzuki K,Yamamoto M,Hernandez-Benitez R,Li Z,Wei C,Soligalla RD,Aizawa E,Hatanaka F,Kurita M,Reddy P,Ocampo A,Hishida T,Sakurai M,Nemeth AN,Nuñez Delicado E,Campistol JM,Magistretti P,Guillen P,Rodriguez Esteban C,G

    更新日期:2019-10-01 00:00:00

  • Cross-regulation of the Nanog and Cdx2 promoters.

    abstract::The first cell fate choice in the mammalian embryo, the segregation of the inner cell mass (ICM) and trophectoderm (TE), is regulated by the mutually antagonistic effects of the transcription factors, Oct4 and Cdx2, while the pluripotency factor, Nanog, is essential to specify the epiblast. We have analyzed the promot...

    journal_title:Cell research

    pub_type: 杂志文章

    doi:10.1038/cr.2009.79

    authors: Chen L,Yabuuchi A,Eminli S,Takeuchi A,Lu CW,Hochedlinger K,Daley GQ

    更新日期:2009-09-01 00:00:00

  • High-density lipoproteins: an emerging target in the prevention of cardiovascular disease.

    abstract::High-density lipoproteins (HDLs) have been well established to protect against the development of atherosclerotic cardiovascular disease. It has become apparent that in addition to the promotion of reverse cholesterol transport, HDLs possess a number of additional functional properties that may contribute to their ben...

    journal_title:Cell research

    pub_type: 杂志文章,评审

    doi:10.1038/sj.cr.7310097

    authors: Cutri BA,Hime NJ,Nicholls SJ

    更新日期:2006-10-01 00:00:00

  • TGF-beta and cancer: is Smad3 a repressor of hTERT gene?

    abstract::Transforming growth factor beta (TGF-beta) carries out tumor suppressor activity in epithelial and lymphoid cells, whereas telomerase is required for most cancers. Although the molecular mechanisms by which TGF-beta acts as a tumor suppressor are yet to be fully established, a link between TGFb and its tumor suppresso...

    journal_title:Cell research

    pub_type: 杂志文章,评审

    doi:10.1038/sj.cr.7310023

    authors: Li H,Xu D,Toh BH,Liu JP

    更新日期:2006-02-01 00:00:00

  • Dapper1 promotes autophagy by enhancing the Beclin1-Vps34-Atg14L complex formation.

    abstract::Autophagy is an intracellular degradation process to clear up aggregated proteins or aged and damaged organelles. The Beclin1-Vps34-Atg14L complex is essential for autophagosome formation. However, how the complex formation is regulated is unclear. Here, we show that Dapper1 (Dpr1) acts as a critical regulator of the ...

    journal_title:Cell research

    pub_type: 杂志文章

    doi:10.1038/cr.2014.84

    authors: Ma B,Cao W,Li W,Gao C,Qi Z,Zhao Y,Du J,Xue H,Peng J,Wen J,Chen H,Ning Y,Huang L,Zhang H,Gao X,Yu L,Chen YG

    更新日期:2014-08-01 00:00:00

  • Cloning of rat sp56, the homologue of mouse sperm ZP3 receptor-sp56.

    abstract::Mouse sp56 is considered as one of the candidates for mouse zona pellucida 3 (mZP3) receptor. Up to date, its homologue has only been cloned from guinea pig, namely AM67. Based on the cDNA sequence of mouse sp56, we designed a pair of primer to amplify its homologue from rat testis cDNA. Using RT-PCR, two fragments of...

    journal_title:Cell research

    pub_type: 杂志文章

    doi:10.1038/sj.cr.7290156

    authors: He XB,Yan YC,Li YP,Koide SS

    更新日期:2003-04-01 00:00:00

  • A critical role of IFNgamma in priming MSC-mediated suppression of T cell proliferation through up-regulation of B7-H1.

    abstract::Bone-marrow-derived mesenchymal stem cells (MSCs) have been shown to possess immunosuppressive properties, e.g., by inhibiting T cell proliferation. Activated T cells can also enhance the immunosuppression ability of MSCs. The precise mechanisms underlying MSC-mediated immunosuppression remain largely undefined, altho...

    journal_title:Cell research

    pub_type: 杂志文章

    doi:10.1038/cr.2008.80

    authors: Sheng H,Wang Y,Jin Y,Zhang Q,Zhang Y,Wang L,Shen B,Yin S,Liu W,Cui L,Li N

    更新日期:2008-08-01 00:00:00

  • C/EBPalphap30 plays transcriptional regulatory roles distinct from C/EBPalphap42.

    abstract::CCAAT/enhancer binding protein alpha (C/EBPalpha) is a transcriptional regulatory factor that inhibits cell proliferation, and alternative translational initiation produces two polypeptides, C/EBPalphap30 and C/EBPalphap42. By expression profiling, it was revealed that C/EBPalphap30 specifically inhibited a unique set...

    journal_title:Cell research

    pub_type: 杂志文章

    doi:10.1038/sj.cr.7310121

    authors: Wang C,Chen X,Wang Y,Gong J,Hu G

    更新日期:2007-04-01 00:00:00

  • Steroid receptor coactivator 3 regulates autophagy in breast cancer cells through macrophage migration inhibitory factor.

    abstract::SRC-3/AIB1 (steroid receptor coactivator 3/amplified in breast cancer 1) is an authentic oncogene that contributes to the development of drug resistance and poor disease-free survival in cancer patients. Autophagy is also an important cell death mechanism that has tumor suppressor function. In this study, we identifie...

    journal_title:Cell research

    pub_type: 杂志文章

    doi:10.1038/cr.2012.44

    authors: Wu MY,Fu J,Xu J,O'Malley BW,Wu RC

    更新日期:2012-06-01 00:00:00

  • Induction of apoptosis in purified animal and plant nuclei by Xenopus egg extracts.

    abstract::We have developed a cell-free system that can trigger the nuclei purified from mouse liver and suspension-cultured carrot cells to undergo apoptosis as defined by the formation of apoptotic bodies and nucleosomal DNA fragments. The effects of different divalent cations and cycloheximide on DNA cleavage in this system ...

    journal_title:Cell research

    pub_type: 杂志文章

    doi:10.1038/sj.cr.7290008

    authors: Jiang ZF,Zhu S,Sun YL,Zhai ZH

    更新日期:1999-06-01 00:00:00

  • Directional migration of leukocytes: their pathological roles in inflammation and strategies for development of anti-inflammatory therapies.

    abstract::Directional migration of leukocytes is indispensable to innate immunity for host defense. However, recruitment of leukocytes to a site of tissue injury also constitutes a leading cause for inflammatory responses. Mechanistically, it involves a cascade of cellular events precisely regulated by temporal and spatial pres...

    journal_title:Cell research

    pub_type: 杂志文章,评审

    doi:10.1038/sj.cr.7290071

    authors: Geng JG

    更新日期:2001-06-01 00:00:00

  • Myosin binding protein C: structural abnormalities in familial hypertrophic cardiomyopathy.

    abstract::The muscle protein myosin binding protein C (MyBPC) is a large multi-domain protein whose role in the sarcomere is complex and not yet fully understood. Mutations in MyBPC are strongly associated with the heart disease familial hypertrophic cardiomyopathy (FHC) and these experiments of nature have provided some insigh...

    journal_title:Cell research

    pub_type: 杂志文章,评审

    doi:10.1038/sj.cr.7290208

    authors: Oakley CE,Hambly BD,Curmi PM,Brown LJ

    更新日期:2004-04-01 00:00:00