Thyroid hormone controls the gene expression of HSV-1 LAT and ICP0 in neuronal cells.

abstract：:Using two-colour flow cytometry >200 antibodies submitted to the 8th International Workshop of Human Leukocyte Differentiation Antigens (HLDA8) have been analyzed for their reactivity with resting and activated CD203c+ basophils. Four antibodies either non-reactive or weakly reactive with resting basophils exhibited a...

journal_title：Cell research

authors： Hennersdorf F,Florian S,Jakob A,Baumgärtner K,Sonneck K,Nordheim A,Biedermann T,Valent P,Bühring HJ

更新日期：2005-05-01 00:00:00

abstract：:New plant type (NPT) or ideal plant architecture (IPA) is an attractive way of increasing yield potential by promoting high resource use efficiency combined with better lodging resistance. In a recent paper in Cell Research, Wang et al. describe how a QTL they identified could bring about the desired NPT architecture ...

journal_title：Cell research

authors： Ordonio RL,Matsuoka M

更新日期：2017-10-01 00:00:00

abstract：:Gonad development requires a coordinated soma-germline interaction that ensures renewal and differentiation of germline and somatic stem cells to ultimately produce mature gametes. The Drosophila tumour suppressor gene discs large (dlg) encodes a septate junction protein functioning during epithelial polarization, asy...

journal_title：Cell research

authors： Papagiannouli F,Mechler BM

更新日期：2009-10-01 00:00:00

abstract：:The nuclear pore complex (NPC) exhibits structural plasticity and has only been characterized at local resolutions of up to 15 Å for the cytoplasmic ring (CR). Here we present a single-particle cryo-electron microscopy (cryo-EM) structure of the CR from Xenopus laevis NPC at average resolutions of 5.5-7.9 Å, with loca...

journal_title：Cell research

authors： Huang G,Zhang Y,Zhu X,Zeng C,Wang Q,Zhou Q,Tao Q,Liu M,Lei J,Yan C,Shi Y

更新日期：2020-06-01 00:00:00

abstract：:The murine skeletal muscle contains hematopoietic stem cells, but this potential has so far not been studied quantitatively or qualitatively in vitro. To quantify the hematopoietic stem cell potential, we have used highly purified SP/CD45(+) cells in long-term culture initiating cell (LTC-IC) assays. The SP/CD45(+) ce...

journal_title：Cell research

authors： Haond C,Farace F,Guillier M,Lécluse Y,Mazurier F,Vainchenker W,Turhan AG

更新日期：2007-09-01 00:00:00

abstract：:Drosophila Wingless (Wg) acts as a morphogen during development. Wg secretion is controlled by a seven-pass transmembrane cargo Wntless (Wls). We have recently identified retromer as a key regulator involved in Wls trafficking. As sorting nexin (SNX) molecules are essential components of the retromer complex, we hypot...

journal_title：Cell research

authors： Zhang P,Wu Y,Belenkaya TY,Lin X

更新日期：2011-12-01 00:00:00

abstract：:Multipotent neural stem/progenitor cells hold great promise for cell therapy. The reprogramming of fibroblasts to induced pluripotent stem cells as well as mature neurons suggests a possibility to convert a terminally differentiated somatic cell into a multipotent state without first establishing pluripotency. Here, w...

journal_title：Cell research

authors： Sheng C,Zheng Q,Wu J,Xu Z,Wang L,Li W,Zhang H,Zhao XY,Liu L,Wang Z,Guo C,Wu HJ,Liu Z,Wang L,He S,Wang XJ,Chen Z,Zhou Q

更新日期：2012-01-01 00:00:00

abstract：:Ferroptosis is an iron-dependent form of regulated necrosis. It is implicated in various human diseases, including ischemic organ damage and cancer. Here, we report the crucial role of autophagy, particularly autophagic degradation of cellular iron storage proteins (a process known as ferritinophagy), in ferroptosis. ...

journal_title：Cell research

authors： Gao M,Monian P,Pan Q,Zhang W,Xiang J,Jiang X

更新日期：2016-09-01 00:00:00

abstract：:NF-κBs are a family of transcription factors that control a number of essential cellular functions including immune responses, cell proliferation and antiapoptosis. NF-κB activities are tightly regulated through upstream signaling molecules and downstream feedback loops. In this review, structural discoveries in the N...

journal_title：Cell research

authors： Zheng C,Yin Q,Wu H

更新日期：2011-01-01 00:00:00

abstract：:Enucleation of erythroblasts during terminal differentiation is unique to mammals. Although erythroid enucleation has been extensively studied, only a few genes, including retinoblastoma protein (Rb), have been identified to regulate nuclear extrusion. It remains largely undefined by which signaling molecules, the ext...

journal_title：Cell research

authors： Schultze SM,Mairhofer A,Li D,Cen J,Beug H,Wagner EF,Hui L

更新日期：2012-03-01 00:00:00

abstract：:The first cell fate choice in the mammalian embryo, the segregation of the inner cell mass (ICM) and trophectoderm (TE), is regulated by the mutually antagonistic effects of the transcription factors, Oct4 and Cdx2, while the pluripotency factor, Nanog, is essential to specify the epiblast. We have analyzed the promot...

journal_title：Cell research

authors： Chen L,Yabuuchi A,Eminli S,Takeuchi A,Lu CW,Hochedlinger K,Daley GQ

更新日期：2009-09-01 00:00:00

abstract：:The functional roles of memory B and T lymphocytes underlie the phenomenal success of prophylactic vaccinations, which have decreased morbidities and mortalities from infectious diseases globally over the last 50 years. However, it is becoming increasingly appreciated that memory cells are also capable of mediating th...

journal_title：Cell research

authors： DiSpirito JR,Shen H

更新日期：2010-01-01 00:00:00

abstract：:The thymus provides the essential microenvironment for T-cell development and maturation. Thymic epithelial cells (TECs), which are composed of thymic cortical epithelial cells (cTECs) and thymic medullary epithelial cells (mTECs), have been well documented to be critical for these tightly regulated processes. It has ...

journal_title：Cell research

authors： Zhang L,Sun L,Zhao Y

更新日期：2007-01-01 00:00:00

abstract：:While studying the neural precursor cell intermediate filament protein known as nestin in the developing mouse brain, we observed a strong cross-reaction of our nestin antibody with a 50 kDa protein that appeared on embryonic day 10 and continued to accumulate until postnatal day 1. Here we report evidence that this p...

journal_title：Cell research

authors： Kong LW,Ding XY,Kitani H,Shiurba R,Jing NH

更新日期：1999-12-01 00:00:00

abstract：:Pluripotent stem cells (PSCs) harbor constitutive DNA replication stress during their rapid proliferation and the consequent genome instability hampers their applications in regenerative medicine. It is therefore important to understand the regulatory mechanisms of replication stress response in PSCs. Here, we report ...

journal_title：Cell research

authors： Zhao B,Zhang W,Cun Y,Li J,Liu Y,Gao J,Zhu H,Zhou H,Zhang R,Zheng P

更新日期：2018-01-01 00:00:00

abstract：:The tumor suppressor PTEN controls a variety of biological processes including cell proliferation, growth, migration, and death. As a master cellular regulator, PTEN itself is also subjected to deliberated regulation to ensure its proper function. Defects in PTEN regulation have a profound impact on carcinogenesis. In...

journal_title：Cell research

authors： Wang X,Jiang X

更新日期：2008-08-01 00:00:00

abstract：:Leaf morphogenesis requires the establishment of adaxial-abaxial polarity after primordium initiation from the shoot apical meristem (SAM). Several families of transcription factors are known to play critical roles in promoting adaxial or abaxial leaf fate. Recently, post-transcriptional gene silencing pathways have b...

journal_title：Cell research

authors： Xu L,Yang L,Huang H

更新日期：2007-06-01 00:00:00

abstract：:In vivo genome editing represents a powerful strategy for both understanding basic biology and treating inherited diseases. However, it remains a challenge to develop universal and efficient in vivo genome-editing tools for tissues that comprise diverse cell types in either a dividing or non-dividing state. Here, we d...

journal_title：Cell research

authors： Suzuki K,Yamamoto M,Hernandez-Benitez R,Li Z,Wei C,Soligalla RD,Aizawa E,Hatanaka F,Kurita M,Reddy P,Ocampo A,Hishida T,Sakurai M,Nemeth AN,Nuñez Delicado E,Campistol JM,Magistretti P,Guillen P,Rodriguez Esteban C,G

更新日期：2019-10-01 00:00:00

abstract：:Tumor initiation and growth depend on its microenvironment in which cancer-associated fibroblasts (CAFs) in tumor stroma play an important role. Prostaglandin E2 (PGE2) and interleukin (IL)-6 signal pathways are involved in the crosstalk between tumor and stromal cells. However, how PGE2-mediated signaling modulates t...

journal_title：Cell research

authors： Li P,Shan JX,Chen XH,Zhang D,Su LP,Huang XY,Yu BQ,Zhi QM,Li CL,Wang YQ,Tomei S,Cai Q,Ji J,Li JF,Chouchane L,Yu YY,Sun FZ,Xu ZH,Liu BY,Zhu ZG

更新日期：2015-05-01 00:00:00

abstract：:Exosome-mediated intercellular communication has become an emerging field of human health and diseases. A recent study published by Cell Research reports that in zebrafish neurons can remotely regulate blood-brain barrier integrity by delivering miR-132 through secretion of exosomes. ...

journal_title：Cell research

authors： Zhao Z,Zlokovic BV

更新日期：2017-07-01 00:00:00

abstract：:Autophagy is a conserved process that delivers cytosolic substances to the lysosome for degradation, but its direct role in the regulation of antiviral innate immunity remains poorly understood. Here, through high-throughput screening, we discovered that CCDC50 functions as a previously unknown autophagy receptor that...

journal_title：Cell research

authors： Hou P,Yang K,Jia P,Liu L,Lin Y,Li Z,Li J,Chen S,Guo S,Pan J,Wu J,Peng H,Zeng W,Li C,Liu Y,Guo D

更新日期：2021-01-01 00:00:00

abstract：:DNA damage can, but does not always, induce cell death. While several pathways linking DNA damage signals to mitochondria-dependent and -independent death machineries have been elucidated, the connectivity of these pathways is subject to regulation by multiple other factors that are not well understood. We have propos...

journal_title：Cell research

authors： Borges HL,Linden R,Wang JY

更新日期：2008-01-01 00:00:00

abstract：:Mechanical deformability is known to increase during cancer progression. Now Ma et al. identify a therapeutic strategy that targets deformable cells by microparticle-based drug delivery. ...

journal_title：Cell research

authors： Hamann J,Overholtzer M

更新日期：2016-06-01 00:00:00

abstract：:Recent studies on enzymes and reader proteins for histone crotonylation support a function of histone crotonylation in transcription. However, the enzyme(s) responsible for histone decrotonylation (HDCR) remains poorly defined. Moreover, it remains to be determined if histone crotonylation is physiologically significa...

journal_title：Cell research

authors： Wei W,Liu X,Chen J,Gao S,Lu L,Zhang H,Ding G,Wang Z,Chen Z,Shi T,Li J,Yu J,Wong J

更新日期：2017-07-01 00:00:00

abstract：:Oct4 is a well-known transcription factor that plays fundamental roles in stem cell self-renewal, pluripotency, and somatic cell reprogramming. However, limited information is available on Oct4-associated protein complexes and their intrinsic protein-protein interactions that dictate Oct4's critical regulatory activit...

journal_title：Cell research

authors： Ding J,Xu H,Faiola F,Ma'ayan A,Wang J

更新日期：2012-01-01 00:00:00

abstract：:KDR (kinase insert domain receptor) phosphorylation induces several effects which lead eventually to cell proliferation and survival. The precise mechanisms by which KDR, once it is activated, communicates with the nucleus are starting to be understood but have not yet been completely unravelled. Two in vitro studies ...

journal_title：Cell research

authors： Blazquez C,Cook N,Micklem K,Harris AL,Gatter KC,Pezzella F

更新日期：2006-01-01 00:00:00

abstract：:A recent paper published in Nature reports sensory nerve fibers in the skin that give local immune cells important instructions for the organization of an immune response; in this particular case the cooperation between the nervous and immune systems had disastrous consequences, namely an auto-destruction of the skin....

journal_title：Cell research

authors： Odoardi F,Neuhuber W,Flügel A

更新日期：2014-09-01 00:00:00

abstract：:Apoptosis is a form of genetically programmed cell death, which plays a key role in regulation of cellularity in a variety of tissue and cell types including the cardiovascular tissues. Under both physiological and pathophysiological conditions, various biophysiological and biochemical factors, including mechanical fo...

journal_title：Cell research

authors： Geng YJ

更新日期：2001-12-01 00:00:00

abstract：:EKLF is an erythroid-specific, zinc finger-containing transcription factor essential for the activation of the mammalian beta globin gene in erythroid cells of definitive lineage. We have prepared a polyclonal anti-mouse EKLF antibody suitable for Western blotting and immunoprecipitation (IP) qualities, and used it to...

journal_title：Cell research

authors： Shyu YC,Wen SC,Lee TL,Chen X,Hsu CT,Chen H,Chen RL,Hwang JL,Shen CK

更新日期：2006-04-01 00:00:00

abstract：:Ruptured and intact plasma membranes are classically considered as hallmarks of necrotic and apoptotic cell death, respectively. As such, apoptosis is usually considered a non-inflammatory process while necrosis triggers inflammation. Recent studies on necroptosis and pyroptosis, two types of programmed necrosis, reve...

journal_title：Cell research

authors： Zhang Y,Chen X,Gueydan C,Han J

更新日期：2018-01-01 00:00:00