Oct4 links multiple epigenetic pathways to the pluripotency network.

abstract：:Circular RNAs (circRNAs) were only recently discovered as a new class of noncoding RNAs, functionally still largely uncharacterized. Three publications that appeared concurrently in Cell Research and Molecular Cell provide initial evidence for certain endogenous circRNAs coding for proteins. ...

journal_title：Cell research

authors： Schneider T,Bindereif A

更新日期：2017-06-01 00:00:00

abstract：:Transcriptional activator-like effectors (TALEs) have emerged as powerful tools for genome editing. A recent study published by Cell Research reports that fusion of thioredoxin to TALEs unlocks their full potential in live-cell imaging to accurately analyze genome instability, telomere attrition and epigenetic alterat...

journal_title：Cell research

authors： Taneja R,Kennedy BK

更新日期：2017-04-01 00:00:00

abstract：:The tumor suppressor PTEN controls a variety of biological processes including cell proliferation, growth, migration, and death. As a master cellular regulator, PTEN itself is also subjected to deliberated regulation to ensure its proper function. Defects in PTEN regulation have a profound impact on carcinogenesis. In...

journal_title：Cell research

authors： Wang X,Jiang X

更新日期：2008-08-01 00:00:00

abstract：:Type I interferon (IFN) production plays pivotal roles in host antiviral innate immune responses, but an excessive production of type I IFN leads to the development of immunopathological conditions. Investigations on the regulatory mechanisms underlying host type I IFN production are currently of great interest. Here,...

journal_title：Cell research

authors： Zheng Q,Hou J,Zhou Y,Yang Y,Xie B,Cao X

更新日期：2015-10-01 00:00:00

abstract：:There are remarkable disparities among patients of different races with prostate cancer; however, the mechanism underlying this difference remains unclear. Here, we present a comprehensive landscape of the transcriptome profiles of 14 primary prostate cancers and their paired normal counterparts from the Chinese popul...

journal_title：Cell research

authors： Ren S,Peng Z,Mao JH,Yu Y,Yin C,Gao X,Cui Z,Zhang J,Yi K,Xu W,Chen C,Wang F,Guo X,Lu J,Yang J,Wei M,Tian Z,Guan Y,Tang L,Xu C,Wang L,Gao X,Tian W,Wang J,Yang H,Wang J,Sun Y

更新日期：2012-05-01 00:00:00

abstract：:There is strong relationship between melanocortin-1 receptor (MC1R) gene variants and human hair color and skin type. Based on a sequencing study of MC1R gene in 50 individuals from the Uygur, Tibetan, Wa and Dai ethnic populations, we discuss the occurrence of 7 mc1r variants consisting of 5 nonsynonymous sites (Val6...

journal_title：Cell research

authors： Peng S,Lu XM,Luo HR,Xiang-Yu JG,Zhang YP

更新日期：2001-03-01 00:00:00

abstract：:Skeletal muscle fitness and plasticity is an important determinant of human health and disease. Mitochondria are essential for maintaining skeletal muscle energy homeostasis by adaptive re-programming to meet the demands imposed by a myriad of physiologic or pathophysiological stresses. Skeletal muscle mitochondrial d...

journal_title：Cell research

authors： Gan Z,Fu T,Kelly DP,Vega RB

更新日期：2018-10-01 00:00:00

abstract：:Platelets play an essential role in hemostasis and atherothrombosis. Owing to their short storage time, there is constant demand for this life-saving blood component. In this study, we report that it is feasible to generate functional megakaryocytes and platelets from human embryonic stem cells (hESCs) on a large scal...

journal_title：Cell research

authors： Lu SJ,Li F,Yin H,Feng Q,Kimbrel EA,Hahm E,Thon JN,Wang W,Italiano JE,Cho J,Lanza R

更新日期：2011-03-01 00:00:00

abstract：:The year of 2013 marked the 50th anniversary of C de Duve's coining of the term "autophagy" for the degradation process of cytoplasmic constituents in the lysosome/vacuole. This year we regretfully lost this great scientist, who contributed much during the early years of research to the field of autophagy. Soon after ...

journal_title：Cell research

authors： Ohsumi Y

更新日期：2014-01-01 00:00:00

abstract：:Endothelial progenitor cells (EPCs) participate in the processes of postnatal neovascularization and re-endothelialization in response to tissue ischemia and endothelial injury. The level of EPCs present has been found to be directly associated with the outcome of cardiovascular diseases, and could be regulated by sti...

journal_title：Cell research

authors： Yin T,Ma X,Zhao L,Cheng K,Wang H

更新日期：2008-07-01 00:00:00

abstract：:The MyD88-independent pathway, one of the two crucial TLR signaling routes, is thought to be a vertebrate innovation. However, a novel Toll/interleukin-1 receptor (TIR) adaptor, designated bbtTICAM, which was identified in the basal chordate amphioxus, links this pathway to invertebrates. The protein architecture of b...

journal_title：Cell research

authors： Yang M,Yuan S,Huang S,Li J,Xu L,Huang H,Tao X,Peng J,Xu A

更新日期：2011-10-01 00:00:00

abstract：:The mixed lineage kinase domain-like (MLKL) protein is a key factor in tumor necrosis factor-induced necroptosis. Recent studies on necroptosis execution revealed a commitment role of MLKL in membrane disruption. However, our knowledge of how MLKL functions on membrane remains very limited. Here we demonstrate that ML...

journal_title：Cell research

authors： Xia B,Fang S,Chen X,Hu H,Chen P,Wang H,Gao Z

更新日期：2016-05-01 00:00:00

abstract：:We found T-type calcium channel blocker Ni2+ can efficiently induce the formation of cement gland in Xenopus laevis animal cap explants. Another T-type specific calcium channel blocker Amiloride can also induce the formation of cement gland, while L-type specific calcium channel blocker Nifedipine has no inductive eff...

journal_title：Cell research

authors： Huang Y,Ding XY

更新日期：1999-03-01 00:00:00

abstract：:New plant type (NPT) or ideal plant architecture (IPA) is an attractive way of increasing yield potential by promoting high resource use efficiency combined with better lodging resistance. In a recent paper in Cell Research, Wang et al. describe how a QTL they identified could bring about the desired NPT architecture ...

journal_title：Cell research

authors： Ordonio RL,Matsuoka M

更新日期：2017-10-01 00:00:00

abstract：:Members of the basic helix-loop-helix (bHLH) gene family play important roles in vertebrate neurogenesis. In this study, confocal microscopy-based fluorescence resonance energy transfer (FRET) is used to monitor bHLH protein-protein interactions under various physiological conditions. Tissue-specific bHLH activators, ...

journal_title：Cell research

authors： Wang C,Bian W,Xia C,Zhang T,Guillemot F,Jing N

更新日期：2006-06-01 00:00:00

abstract：:The first cell fate choice in the mammalian embryo, the segregation of the inner cell mass (ICM) and trophectoderm (TE), is regulated by the mutually antagonistic effects of the transcription factors, Oct4 and Cdx2, while the pluripotency factor, Nanog, is essential to specify the epiblast. We have analyzed the promot...

journal_title：Cell research

authors： Chen L,Yabuuchi A,Eminli S,Takeuchi A,Lu CW,Hochedlinger K,Daley GQ

更新日期：2009-09-01 00:00:00

abstract：:Entry into mitosis is driven by signaling cascades of mitotic kinases. Our recent studies show that TTK, a kinetochore-associated protein kinase, interacts with CENP-E, a mitotic kinesin located to corona fiber of kinetochore. Using immunoelectron microscopy, here we show that TTK is present at the nuclear pore adjace...

journal_title：Cell research

authors： Dou Z,Sawagechi A,Zhang J,Luo H,Brako L,Yao XB

更新日期：2003-12-01 00:00:00

abstract：:Glial cell line-derived neurotrophic factor (GDNF) was originally recognized for its ability to promote survival of midbrain dopaminergic neurons, but it has since been demonstrated to be crucial for the survival and differentiation of many neuronal subpopulations, including motor neurons, sympathetic neurons, sensory...

journal_title：Cell research

authors： Jiao L,Zhang Y,Hu C,Wang YG,Huang A,He C

更新日期：2011-02-01 00:00:00

abstract：:Immunization with inactivated autoreactive T cells is an effective therapeutic approach to ameliorating autoimmune diseases, while the underlying mechanisms that regulate autoreactive T cells are not completely understood. This study tested the hypothesis that T-cell vaccination (TCV) inhibits autoimmune diabetes in m...

journal_title：Cell research

authors： Wang M,Yang L,Sheng X,Chen W,Tang H,Sheng H,Xi B,Zang YQ

更新日期：2011-09-01 00:00:00

abstract：:A novel ribosome-inactivating protein designated Moschatin from the mature seeds of pumpkin (Cucurbita moschata) has been successively purified to homogeneity, using ammonium sulfate precipitation, CM-cellulose 52 column chromatography, Blue Sepharose CL-6B Affinity column chromatography and FPLC size-exclusion column...

journal_title：Cell research

authors： Xia HC,Li F,Li Z,Zhang ZC

更新日期：2003-10-01 00:00:00

abstract：:Parthenogenetic embryonic stem (pES) cells provide a valuable in vitro model system for studying the molecular mechanisms that underlie genomic imprinting. However, the pluripotency of pES cells and the expression profiles of paternally expressed imprinted genes have not been fully explored. In this study, three mouse...

journal_title：Cell research

authors： Jiang H,Sun B,Wang W,Zhang Z,Gao F,Shi G,Cui B,Kong X,He Z,Ding X,Kuang Y,Fei J,Sun YJ,Feng Y,Jin Y

更新日期：2007-09-01 00:00:00

abstract：:Leaf morphogenesis requires the establishment of adaxial-abaxial polarity after primordium initiation from the shoot apical meristem (SAM). Several families of transcription factors are known to play critical roles in promoting adaxial or abaxial leaf fate. Recently, post-transcriptional gene silencing pathways have b...

journal_title：Cell research

authors： Xu L,Yang L,Huang H

更新日期：2007-06-01 00:00:00

abstract：:A monoclonal antibody, LC-1, recognizing lung cancer associated common antigens was obtained in authors' laboratory. Its single chain Fv fragment (ScFv) named LC-1 ScFv was constructed based on recombinant phage displayed techniques. For expression on cell membrane, LC-1 ScFv was cloned into pDisplay vector, which dir...

journal_title：Cell research

authors： Chen L,Li G,Tang L,Wang J,Ge XR

更新日期：2002-03-01 00:00:00

abstract：:Recent studies on enzymes and reader proteins for histone crotonylation support a function of histone crotonylation in transcription. However, the enzyme(s) responsible for histone decrotonylation (HDCR) remains poorly defined. Moreover, it remains to be determined if histone crotonylation is physiologically significa...

journal_title：Cell research

authors： Wei W,Liu X,Chen J,Gao S,Lu L,Zhang H,Ding G,Wang Z,Chen Z,Shi T,Li J,Yu J,Wong J

更新日期：2017-07-01 00:00:00

abstract：:Spontaneous Ca2+ oscillations in vascular smooth muscle cells have been modeled using a single Ca2+ pool. This report describes spontaneous Ca2+ oscillations dependent on two separate Ca2+ sources for the nuclear versus cytoplasmic compartments. Changes in free intracellular Ca2+ were monitored with ratiometric Ca2+- ...

journal_title：Cell research

authors： Fedoryak OD,Searls Y,Smirnova IV,Burns DM,Stehno-Bittel L

更新日期：2004-10-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) play a significant role in regulating angiogenesis, the process of new blood vessel formation. Interstitial collagenase (MMP-1), 72 kDa gelatinase A/type IV collagenase (MMP-2), and 92 kDa gelatinase B/type IV collagenase (MMP-9) diss...

journal_title：Cell research

authors： Sang QX

更新日期：1998-09-01 00:00:00

abstract：:We have developed a cell-free system that can trigger the nuclei purified from mouse liver and suspension-cultured carrot cells to undergo apoptosis as defined by the formation of apoptotic bodies and nucleosomal DNA fragments. The effects of different divalent cations and cycloheximide on DNA cleavage in this system ...

journal_title：Cell research

authors： Jiang ZF,Zhu S,Sun YL,Zhai ZH

更新日期：1999-06-01 00:00:00

abstract：:DNA replication stress, a feature of human cancers, often leads to instability at specific genomic loci, such as the common fragile sites (CFSs). Cells experiencing DNA replication stress may also exhibit mitotic DNA synthesis (MiDAS). To understand the physiological function of MiDAS and its relationship to CFSs, we ...

journal_title：Cell research

authors： Macheret M,Bhowmick R,Sobkowiak K,Padayachy L,Mailler J,Hickson ID,Halazonetis TD

更新日期：2020-11-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Cell research

authors： Ma M,Liu JJ,Li Y,Huang Y,Ta N,Chen Y,Fu H,Ye MD,Ding Y,Huang W,Wang J,Dong MQ,Yu L,Wang HW

更新日期：2020-06-01 00:00:00

abstract：:The human CD14(+) monocyte compartment is composed by two subsets based on CD16 expression. We previously reported that this compartment is perturbed in tuberculosis (TB) patients, as reflected by the expansion of CD16(+) monocytes along with disease severity. Whether this unbalance is beneficial or detrimental to hos...

journal_title：Cell research

authors： Lastrucci C,Bénard A,Balboa L,Pingris K,Souriant S,Poincloux R,Al Saati T,Rasolofo V,González-Montaner P,Inwentarz S,Moraña EJ,Kondova I,Verreck FA,Sasiain Mdel C,Neyrolles O,Maridonneau-Parini I,Lugo-Villarino G,Cougou

更新日期：2015-12-01 00:00:00