Abstract:
:Recent studies on enzymes and reader proteins for histone crotonylation support a function of histone crotonylation in transcription. However, the enzyme(s) responsible for histone decrotonylation (HDCR) remains poorly defined. Moreover, it remains to be determined if histone crotonylation is physiologically significant and functionally distinct from or redundant to histone acetylation. Here we present evidence that class I histone deacetylases (HDACs) rather than sirtuin family deacetylases (SIRTs) are the major histone decrotonylases, and that histone crotonylation is as dynamic as histone acetylation in mammalian cells. Notably, we have generated novel HDAC1 and HDAC3 mutants with impaired HDAC but intact HDCR activity. Using these mutants we demonstrate that selective HDCR in mammalian cells correlates with a broad transcriptional repression and diminished promoter association of crotonylation but not acetylation reader proteins. Furthermore, we show that histone crotonylation is enriched in and required for self-renewal of mouse embryonic stem cells.
journal_name
Cell Resjournal_title
Cell researchauthors
Wei W,Liu X,Chen J,Gao S,Lu L,Zhang H,Ding G,Wang Z,Chen Z,Shi T,Li J,Yu J,Wong Jdoi
10.1038/cr.2017.68subject
Has Abstractpub_date
2017-07-01 00:00:00pages
898-915issue
7eissn
1001-0602issn
1748-7838pii
cr201768journal_volume
27pub_type
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