Abstract:
:In searching for differentially expressed genes in human uterine leiomyomas (ULs), suppression subtractive hybridization was used to construct an UL up-regulated library, which turned out to represent 88 genes. After two rounds of screening by reverse Northern analysis, twenty genes were proved to be up-regulated, including seventeen known genes and three genes with unknown function. All these genes were firstly associated with UL. Three genes with notable difference were selected for Northern confirmation. Our results proved the authenticity of the twenty genes. One gene named Phospholipase A2 (PLA2) showed up-regulation in 4/6 of the patients and investigation of tissue distribution indicated that it had obvious expression in prostate, testis, liver, heart and skeletal muscle.
journal_name
Cell Resjournal_title
Cell researchauthors
Li B,Zhang YLdoi
10.1038/sj.cr.7290127keywords:
subject
Has Abstractpub_date
2002-09-01 00:00:00pages
215-21issue
3-4eissn
1001-0602issn
1748-7838journal_volume
12pub_type
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