Leptin: a multifunctional hormone.

abstract：:The pituitary adenylate cyclase-activating polypeptide type I receptor (PAC1R) belongs to the secretin receptor family and is widely distributed in the central neural system and peripheral organs. Abnormal activation of the receptor mediates trigeminovascular activation and sensitization, which is highly related to mi...

journal_title：Cell research

authors： Wang J,Song X,Zhang D,Chen X,Li X,Sun Y,Li C,Song Y,Ding Y,Ren R,Harrington EH,Hu LA,Zhong W,Xu C,Huang X,Wang HW,Ma Y

更新日期：2020-05-01 00:00:00

abstract：:Exosome-mediated intercellular communication has become an emerging field of human health and diseases. A recent study published by Cell Research reports that in zebrafish neurons can remotely regulate blood-brain barrier integrity by delivering miR-132 through secretion of exosomes. ...

journal_title：Cell research

authors： Zhao Z,Zlokovic BV

更新日期：2017-07-01 00:00:00

abstract：:Protein ubiquitination by E3 ubiquitin ligases plays an important role in cancer development. In this study, we provide experimental evidence that a RING-finger-containing protein RNF13 is an ER/Golgi membrane-associated E3 ubiquitin ligase and its RING finger domain is required for the ubiquitin ligase activity. Immu...

journal_title：Cell research

authors： Zhang Q,Meng Y,Zhang L,Chen J,Zhu D

更新日期：2009-03-01 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive and complex neurodegenerative disease in which the γ-secretase-mediated amyloid-β (Aβ) pathology plays an important role. We found that a multifunctional protein, β-arrestin1, facilitated the formation of NCT/APH-1 (anterior pharynx-defective phenotype 1) precomplex and mature...

journal_title：Cell research

authors： Liu X,Zhao X,Zeng X,Bossers K,Swaab DF,Zhao J,Pei G

更新日期：2013-03-01 00:00:00

abstract：:DNA hydrolysis is a biochemical process often associated with different forms of cell death, including apoptosis. In a recent paper published in Cell Discovery, Du et al. report that synaptic acetylcholinesterase (AChE-S) shows an unexpected enzymatic activity as DNase switched on after cytotoxic insults. ...

journal_title：Cell research

authors： Sánchez-Osuna M,Yuste VJ

更新日期：2015-06-01 00:00:00

abstract：:Amycolatopsis mediterranei is used for industry-scale production of rifamycin, which plays a vital role in antimycobacterial therapy. As the first sequenced genome of the genus Amycolatopsis, the chromosome of strain U32 comprising 10,236,715 base pairs, is one of the largest prokaryotic genomes ever sequenced so far....

journal_title：Cell research

authors： Zhao W,Zhong Y,Yuan H,Wang J,Zheng H,Wang Y,Cen X,Xu F,Bai J,Han X,Lu G,Zhu Y,Shao Z,Yan H,Li C,Peng N,Zhang Z,Zhang Y,Lin W,Fan Y,Qin Z,Hu Y,Zhu B,Wang S,Ding X,Zhao GP

更新日期：2010-10-01 00:00:00

abstract：:Using two-colour flow cytometry >200 antibodies submitted to the 8th International Workshop of Human Leukocyte Differentiation Antigens (HLDA8) have been analyzed for their reactivity with resting and activated CD203c+ basophils. Four antibodies either non-reactive or weakly reactive with resting basophils exhibited a...

journal_title：Cell research

authors： Hennersdorf F,Florian S,Jakob A,Baumgärtner K,Sonneck K,Nordheim A,Biedermann T,Valent P,Bühring HJ

更新日期：2005-05-01 00:00:00

abstract：:Multipotent neural stem/progenitor cells hold great promise for cell therapy. The reprogramming of fibroblasts to induced pluripotent stem cells as well as mature neurons suggests a possibility to convert a terminally differentiated somatic cell into a multipotent state without first establishing pluripotency. Here, w...

journal_title：Cell research

authors： Sheng C,Zheng Q,Wu J,Xu Z,Wang L,Li W,Zhang H,Zhao XY,Liu L,Wang Z,Guo C,Wu HJ,Liu Z,Wang L,He S,Wang XJ,Chen Z,Zhou Q

更新日期：2012-01-01 00:00:00

abstract：:Recent outbreaks of Zika virus (ZIKV) highlight an urgent need for therapeutics. The protease complex NS2B-NS3 plays essential roles during flaviviral polyprotein processing, and thus represents an attractive drug target. Here, we developed a split luciferase complementation-based high-throughput screening assay to id...

journal_title：Cell research

authors： Li Z,Brecher M,Deng YQ,Zhang J,Sakamuru S,Liu B,Huang R,Koetzner CA,Allen CA,Jones SA,Chen H,Zhang NN,Tian M,Gao F,Lin Q,Banavali N,Zhou J,Boles N,Xia M,Kramer LD,Qin CF,Li H

更新日期：2017-08-01 00:00:00

abstract：:Paramyxoviruses evade antiviral immune response using a small nonstructural protein, V, which binds to the host dsRNA sensor MDA5 and prevents it from activating the interferon signaling pathway. A recent crystal structure of the V protein in complex with MDA5, published in Science, revealed that V disrupts the struct...

journal_title：Cell research

authors： Wu B,Hur S

更新日期：2013-06-01 00:00:00

abstract：:It was the first time demonstrated by us that the number of newborn neurons was increased after making lesion in forebrain of adult ring dove (Streptopelia risoria) by means of autoradiography and immunohistochemistry. Neurogenesis in the adult avian is restricted to the telencephalon. In doves with bilateral electrol...

journal_title：Cell research

authors： Zuo MX

更新日期：1998-06-01 00:00:00

abstract：:Immunization with inactivated autoreactive T cells is an effective therapeutic approach to ameliorating autoimmune diseases, while the underlying mechanisms that regulate autoreactive T cells are not completely understood. This study tested the hypothesis that T-cell vaccination (TCV) inhibits autoimmune diabetes in m...

journal_title：Cell research

authors： Wang M,Yang L,Sheng X,Chen W,Tang H,Sheng H,Xi B,Zang YQ

更新日期：2011-09-01 00:00:00

abstract：:The murine skeletal muscle contains hematopoietic stem cells, but this potential has so far not been studied quantitatively or qualitatively in vitro. To quantify the hematopoietic stem cell potential, we have used highly purified SP/CD45(+) cells in long-term culture initiating cell (LTC-IC) assays. The SP/CD45(+) ce...

journal_title：Cell research

authors： Haond C,Farace F,Guillier M,Lécluse Y,Mazurier F,Vainchenker W,Turhan AG

更新日期：2007-09-01 00:00:00

abstract：:A recent study led by Professor Rob Martienssen in Cell showed that 3'-tRNA-derived small RNAs can suppress long terminal repeat retrotransposon activity in mammalian cells by mechanisms independent of DNA-associated epigenetic marks, suggesting how the genome may defend itself from retrotransposon invasion during epi...

journal_title：Cell research

authors： Zhang Y,Shi J,Chen Q

更新日期：2017-11-01 00:00:00

abstract：:Kinesins are microtubule-based motors involved in various intracellular transports. Neurons, flagellated cells, and pigment cells have been traditionally used as model systems to study the cellular functions of kinesins. Here, we report silkworm posterior silkgland (PSG), specialized cells with an extensive endomembra...

journal_title：Cell research

authors： Wang Q,Teng J,Shen B,Zhang W,Guo Y,Su X,Zhang C,Yu AC,Chen J

更新日期：2010-06-01 00:00:00

abstract：:The cytotoxic T lymphocyte antigen-4 (CTLA-4)-blocking antibody ipilimumab induces immune-mediated long-term control of metastatic melanoma in a fraction of patients. Although ipilimumab undoubtedly exerts its therapeutic effects via immunostimulation, thus far clinically useful, immunologically relevant biomarkers th...

journal_title：Cell research

authors： Hannani D,Vétizou M,Enot D,Rusakiewicz S,Chaput N,Klatzmann D,Desbois M,Jacquelot N,Vimond N,Chouaib S,Mateus C,Allison JP,Ribas A,Wolchok JD,Yuan J,Wong P,Postow M,Mackiewicz A,Mackiewicz J,Schadendorff D,Jaeger

更新日期：2015-02-01 00:00:00

abstract：:LRP16 was previously identified as an estrogen-induced gene in breast cancer cells. The responsiveness of LRP16 to estrogen and its functional effects in endometrial cancer (EC) cells are still unclear. Here, we show that the mRNA level and promoter activity of the LRP16 gene were significantly increased by 17beta-est...

journal_title：Cell research

authors： Meng YG,Han WD,Zhao YL,Huang K,Si YL,Wu ZQ,Mu YM

更新日期：2007-10-01 00:00:00

abstract：:DNA methylation is a fundamental epigenetic mechanism governing regulation of gene expression during mammalian development. A recent study published in Nature shows a novel long noncoding RNA (lncRNA) arising from the CEBPA gene locus (termed ecCEBPA) that is critical for regulation of DNA methylation at this site thr...

journal_title：Cell research

authors： Lai F,Shiekhattar R

更新日期：2014-03-01 00:00:00

abstract：:UV-B (280-315 nm) is an integral part of solar radiation and can act either as a stress inducer or as a developmental signal. In recent years, increasing attention has been paid to the low-fluence UV-B-induced photomorphogenic response and several key players in this response have been identified, which include UVR8 (...

journal_title：Cell research

authors： Jiang L,Wang Y,Li QF,Björn LO,He JX,Li SS

更新日期：2012-06-01 00:00:00

abstract：:High sodium consumption has been raising interest as a putative environmental factor linking Western lifestyle to the growing epidemic of autoimmune and inflammatory diseases. Now Zhang and colleagues show that high sodium drives macrophage to acquire a new proinflammatory effector phenotype with a distinct signature,...

journal_title：Cell research

authors： Lucca LE,Hafler DA

更新日期：2015-08-01 00:00:00

abstract：:There are remarkable disparities among patients of different races with prostate cancer; however, the mechanism underlying this difference remains unclear. Here, we present a comprehensive landscape of the transcriptome profiles of 14 primary prostate cancers and their paired normal counterparts from the Chinese popul...

journal_title：Cell research

authors： Ren S,Peng Z,Mao JH,Yu Y,Yin C,Gao X,Cui Z,Zhang J,Yi K,Xu W,Chen C,Wang F,Guo X,Lu J,Yang J,Wei M,Tian Z,Guan Y,Tang L,Xu C,Wang L,Gao X,Tian W,Wang J,Yang H,Wang J,Sun Y

更新日期：2012-05-01 00:00:00

abstract：:While N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic mRNA, is linked to cell differentiation and tissue development, the biological significance of m6A modification in mammalian glial development remains unknown. Here, we identify a novel m6A reader, Prrc2a (Proline rich coiled-coil 2 ...

journal_title：Cell research

authors： Wu R,Li A,Sun B,Sun JG,Zhang J,Zhang T,Chen Y,Xiao Y,Gao Y,Zhang Q,Ma J,Yang X,Liao Y,Lai WY,Qi X,Wang S,Shu Y,Wang HL,Wang F,Yang YG,Yuan Z

更新日期：2019-01-01 00:00:00

abstract：:Toll-Like Receptors (TLRs) play critical roles in the early innate immune response to invading pathogens by sensing microorganisms; a number of accessory molecules have been shown to assist microbial recognition by TLRs. In a recent paper in Cell Research, Yang et al. demonstrate that Mex3B is associated with TLR3 in ...

journal_title：Cell research

authors： Zhu S,Wang G,Lei X,Flavell RA

更新日期：2016-04-01 00:00:00

abstract：:CD8 engagement with class I major histocompatibility antigens greatly enhances T-cell activation, but it is not clear how this is achieved. We address the question of whether or not the antibody-mediated ligation of CD8 alone induces transcriptional remodeling in a T-cell clone, using serial analysis of gene expressio...

journal_title：Cell research

authors： Abidi SH,Dong T,Vuong MT,Sreenu VB,Rowland-Jones SL,Evans EJ,Davis SJ

更新日期：2008-06-01 00:00:00

abstract：:The 5' fragment (1 647 bp) of the cotton glucuronosyltransferase gene (GhGlcAT1) was transcriptionally fused to the beta-glucuronidase (GUS) gene, and functionally analyzed for important regulatory regions controlling gene expression in transgenic tobacco plants. GUS activity analysis revealed that the full-length pro...

journal_title：Cell research

authors： Wu AM,Lv SY,Liu JY

更新日期：2007-02-01 00:00:00

abstract：:Wnt/β-catenin signaling is essential for the initiation of dorsal-ventral patterning during vertebrate embryogenesis. Maternal β-catenin accumulates in dorsal marginal nuclei during cleavage stages, but its critical target genes essential for dorsalization are silent until mid-blastula transition (MBT). Here, we find ...

journal_title：Cell research

authors： Wei S,Dai M,Liu Z,Ma Y,Shang H,Cao Y,Wang Q

更新日期：2017-02-01 00:00:00

abstract：:The family members of the mitogen-activated protein (MAP) kinases mediate a wide variety of cellular behaviors in response to extracellular stimuli. One of the four main sub-groups, the p38 group of MAP kinases, serve as a nexus for signal transduction and play a vital role in numerous biological processes. In this re...

journal_title：Cell research

authors： Zarubin T,Han J

更新日期：2005-01-01 00:00:00

abstract：:Plant responses to developmental and environmental cues are often mediated by calcium (Ca(2+)) signals that are transmitted by diverse calcium sensors. The calcineurin B-like (CBL) protein family represents calcium sensors that decode calcium signals through specific interactions with a group of CBL-interacting protei...

journal_title：Cell research

authors： Tang RJ,Liu H,Yang Y,Yang L,Gao XS,Garcia VJ,Luan S,Zhang HX

更新日期：2012-12-01 00:00:00

abstract：:Mouse sp56 is considered as one of the candidates for mouse zona pellucida 3 (mZP3) receptor. Up to date, its homologue has only been cloned from guinea pig, namely AM67. Based on the cDNA sequence of mouse sp56, we designed a pair of primer to amplify its homologue from rat testis cDNA. Using RT-PCR, two fragments of...

journal_title：Cell research

authors： He XB,Yan YC,Li YP,Koide SS

更新日期：2003-04-01 00:00:00

abstract：:Members of the basic helix-loop-helix (bHLH) gene family play important roles in vertebrate neurogenesis. In this study, confocal microscopy-based fluorescence resonance energy transfer (FRET) is used to monitor bHLH protein-protein interactions under various physiological conditions. Tissue-specific bHLH activators, ...

journal_title：Cell research

authors： Wang C,Bian W,Xia C,Zhang T,Guillemot F,Jing N

更新日期：2006-06-01 00:00:00