Abstract:
:CD8 engagement with class I major histocompatibility antigens greatly enhances T-cell activation, but it is not clear how this is achieved. We address the question of whether or not the antibody-mediated ligation of CD8 alone induces transcriptional remodeling in a T-cell clone, using serial analysis of gene expression. Even though it fails to induce overt phenotypic changes, we find that CD8 ligation profoundly alters transcription in the T-cell clone, at a scale comparable to that induced by antibody-mediated ligation of CD3. The character of the resulting changes is distinct, however, with the net effect of CD8 ligation being substantially inhibitory. We speculate that ligating CD8 induces weak, T-cell receptor (TCR)-mediated inhibitory signals reminiscent of the effects of TCR antagonists. Our results imply that CD8 ligation alone is incapable of activating the T-cell clone because it fails to fully induce NFAT-dependent transcription.
journal_name
Cell Resjournal_title
Cell researchauthors
Abidi SH,Dong T,Vuong MT,Sreenu VB,Rowland-Jones SL,Evans EJ,Davis SJdoi
10.1038/cr.2008.56subject
Has Abstractpub_date
2008-06-01 00:00:00pages
641-8issue
6eissn
1001-0602issn
1748-7838pii
cr200856journal_volume
18pub_type
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