Releasing the break on X chromosome inactivation: Rnf12/RLIM targets REX1 for degradation.

abstract：:The Beclin 1 gene is a haplo-insufficient tumor suppressor and plays an essential role in autophagy. However, the molecular mechanism by which Beclin 1 functions remains largely unknown. Here we report the crystal structure of the evolutionarily conserved domain (ECD) of Beclin 1 at 1.6 Å resolution. Beclin 1 ECD exhi...

journal_title：Cell research

authors： Huang W,Choi W,Hu W,Mi N,Guo Q,Ma M,Liu M,Tian Y,Lu P,Wang FL,Deng H,Liu L,Gao N,Yu L,Shi Y

更新日期：2012-03-01 00:00:00

abstract：:The PML gene is involved in the t(15;17) translocation of acute promyelocytic leukaemia (APL), which generates the oncogenic fusion protein PML (promyelocytic leukaemia protein)-retinoic acid receptor alpha. The PML protein localises to a subnuclear structure called the PML nuclear domain (PML-ND), of which PML is the...

journal_title：Cell research

authors： Salomoni P,Ferguson BJ,Wyllie AH,Rich T

更新日期：2008-06-01 00:00:00

abstract：:T helper (TH)-cell subsets, such as TH1 and TH17, mediate inflammation in both peripheral tissues and central nervous system. Here we show that STAT5 is required for T helper-cell pathogenicity in autoimmune neuroinflammation but not in experimental colitis. Although STAT5 promotes regulatory T cell generation and imm...

journal_title：Cell research

authors： Sheng W,Yang F,Zhou Y,Yang H,Low PY,Kemeny DM,Tan P,Moh A,Kaplan MH,Zhang Y,Fu XY

更新日期：2014-12-01 00:00:00

abstract：:Dendritic cells (DCs) play a pivotal role in priming adaptive immunity. However, the involvement of DCs in controlling excessive and deleterious T cell responses remains poorly defined. Moreover, the metabolic dependence and regulation of DC function are unclear. Here we show that LKB1 signaling in DCs functions as a ...

journal_title：Cell research

authors： Wang Y,Du X,Wei J,Long L,Tan H,Guy C,Dhungana Y,Qian C,Neale G,Fu YX,Yu J,Peng J,Chi H

更新日期：2019-05-01 00:00:00

abstract：:Leaf morphogenesis requires the establishment of adaxial-abaxial polarity after primordium initiation from the shoot apical meristem (SAM). Several families of transcription factors are known to play critical roles in promoting adaxial or abaxial leaf fate. Recently, post-transcriptional gene silencing pathways have b...

journal_title：Cell research

authors： Xu L,Yang L,Huang H

更新日期：2007-06-01 00:00:00

abstract：:Influenza A viruses (IAVs), particularly H1N1, H5N1 and H7N9, pose a substantial threat to public health worldwide. Here, we report that MIR2911, a honeysuckle (HS)-encoded atypical microRNA, directly targets IAVs with a broad spectrum. MIR2911 is highly stable in HS decoction, and continuous drinking or gavage feedin...

journal_title：Cell research

authors： Zhou Z,Li X,Liu J,Dong L,Chen Q,Liu J,Kong H,Zhang Q,Qi X,Hou D,Zhang L,Zhang G,Liu Y,Zhang Y,Li J,Wang J,Chen X,Wang H,Zhang J,Chen H,Zen K,Zhang CY

更新日期：2015-01-01 00:00:00

abstract：:N6-methyladenine (N6-mA) of DNA is an emerging epigenetic mark in mammalian genome. Levels of N6-mA undergo drastic fluctuation during early embryogenesis, indicative of active regulation. Here we show that the 2-oxoglutarate-dependent oxygenase ALKBH1 functions as a nuclear eraser of N6-mA in unpairing regions (e.g.,...

journal_title：Cell research

authors： Zhang M,Yang S,Nelakanti R,Zhao W,Liu G,Li Z,Liu X,Wu T,Xiao A,Li H

更新日期：2020-03-01 00:00:00

abstract：:Efficient generation of functional human vascular endothelial cells and smooth muscle cells from pluripotent stem cells is an extensively studied topic and of great interest in the stem cell field. Though thought to be technically complex and difficult, substantial progress has been made towards this direction. Here w...

journal_title：Cell research

authors： Yi F,Qu J,Liu GH,Izpisua Belmonte JC

更新日期：2013-01-01 00:00:00

abstract：:Why stem cell numbers decline with age is a major question in regenerative biology and medicine. Skeletal muscle has emerged as a powerful paradigm to address this issue. Recently, genetic and cell marking strategies were used to uncover a new and causal relationship between muscle stem cells and differentiated fibers...

journal_title：Cell research

authors： Tajbakhsh S

更新日期：2013-04-01 00:00:00

abstract：:We have developed a cell-free system that can trigger the nuclei purified from mouse liver and suspension-cultured carrot cells to undergo apoptosis as defined by the formation of apoptotic bodies and nucleosomal DNA fragments. The effects of different divalent cations and cycloheximide on DNA cleavage in this system ...

journal_title：Cell research

authors： Jiang ZF,Zhu S,Sun YL,Zhai ZH

更新日期：1999-06-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Cell research

authors： Guarnerio J,Zhang Y,Cheloni G,Panella R,Katon JM,Simpson M,Matsumoto A,Papa A,Loretelli C,Petri A,Kauppinen S,Garbutt C,Nielsen GP,Deshpande V,Castillo-Martin M,Cordon-Cardo C,Spentzos D,Clohessy JG,Batish M,Pandolf

更新日期：2020-02-01 00:00:00

abstract：:Apoptosis is a form of genetically programmed cell death, which plays a key role in regulation of cellularity in a variety of tissue and cell types including the cardiovascular tissues. Under both physiological and pathophysiological conditions, various biophysiological and biochemical factors, including mechanical fo...

journal_title：Cell research

authors： Geng YJ

更新日期：2001-12-01 00:00:00

abstract：:Drosophila Wingless (Wg) acts as a morphogen during development. Wg secretion is controlled by a seven-pass transmembrane cargo Wntless (Wls). We have recently identified retromer as a key regulator involved in Wls trafficking. As sorting nexin (SNX) molecules are essential components of the retromer complex, we hypot...

journal_title：Cell research

authors： Zhang P,Wu Y,Belenkaya TY,Lin X

更新日期：2011-12-01 00:00:00

abstract：:Phosphatidylinositol 3-phosphate (PI3P) plays essential roles in vesicular trafficking, organelle biogenesis and autophagy. Two class III phosphatidylinositol 3-kinase (PI3KC3) complexes have been identified in mammals, the ATG14L complex (PI3KC3-C1) and the UVRAG complex (PI3KC3-C2). PI3KC3-C1 is crucial for autophag...

journal_title：Cell research

authors： Ma M,Liu JJ,Li Y,Huang Y,Ta N,Chen Y,Fu H,Ye MD,Ding Y,Huang W,Wang J,Dong MQ,Yu L,Wang HW

更新日期：2017-08-01 00:00:00

abstract：:Cellular biological activities are tightly controlled by intracellular signaling processes initiated by extracellular signals. Protein tyrosine phosphatases, which remove phosphate groups from phosphorylated signaling molecules, play equally important tyrosine roles as protein tyrosine kinases in signal transduction. ...

journal_title：Cell research

authors： Qu CK

更新日期：2000-12-01 00:00:00

abstract：:Endothelial progenitor cells (EPCs) participate in the processes of postnatal neovascularization and re-endothelialization in response to tissue ischemia and endothelial injury. The level of EPCs present has been found to be directly associated with the outcome of cardiovascular diseases, and could be regulated by sti...

journal_title：Cell research

authors： Yin T,Ma X,Zhao L,Cheng K,Wang H

更新日期：2008-07-01 00:00:00

abstract：:Classical methyl-CpG binding proteins contain the conserved DNA binding motif methyl-cytosine binding domain (MBD), which preferentially binds to methylated CpG dinucleotides. These proteins serve as transcriptional repressors, mediating gene silencing via DNA cytosine methylation. Mutations in methyl-CpG binding prot...

journal_title：Cell research

authors： Fan G,Hutnick L

更新日期：2005-04-01 00:00:00

abstract：:Circular RNAs (circRNAs) were only recently discovered as a new class of noncoding RNAs, functionally still largely uncharacterized. Three publications that appeared concurrently in Cell Research and Molecular Cell provide initial evidence for certain endogenous circRNAs coding for proteins. ...

journal_title：Cell research

authors： Schneider T,Bindereif A

更新日期：2017-06-01 00:00:00

abstract：:The partitioning-defective 3 (Par3), a key component in the conserved Par3/Par6/aPKC complex, plays fundamental roles in cell polarity. Herein we report the identification of Ku70 and Ku80 as novel Par3-interacting proteins through an in vitro binding assay followed by liquid chromatography-tandem mass spectrometry. K...

journal_title：Cell research

authors： Fang L,Wang Y,Du D,Yang G,Tak Kwok T,Kai Kong S,Chen B,Chen DJ,Chen Z

更新日期：2007-02-01 00:00:00

abstract：:Glial cell line-derived neurotrophic factor (GDNF) was originally recognized for its ability to promote survival of midbrain dopaminergic neurons, but it has since been demonstrated to be crucial for the survival and differentiation of many neuronal subpopulations, including motor neurons, sympathetic neurons, sensory...

journal_title：Cell research

authors： Jiao L,Zhang Y,Hu C,Wang YG,Huang A,He C

更新日期：2011-02-01 00:00:00

abstract：:There are remarkable disparities among patients of different races with prostate cancer; however, the mechanism underlying this difference remains unclear. Here, we present a comprehensive landscape of the transcriptome profiles of 14 primary prostate cancers and their paired normal counterparts from the Chinese popul...

journal_title：Cell research

authors： Ren S,Peng Z,Mao JH,Yu Y,Yin C,Gao X,Cui Z,Zhang J,Yi K,Xu W,Chen C,Wang F,Guo X,Lu J,Yang J,Wei M,Tian Z,Guan Y,Tang L,Xu C,Wang L,Gao X,Tian W,Wang J,Yang H,Wang J,Sun Y

更新日期：2012-05-01 00:00:00

abstract：:All known subtypes of influenza A viruses are maintained in wild waterfowl, the natural reservoir of these viruses. Influenza A viruses are isolated from a variety of animal species with varying morbidity and mortality rates. More importantly, influenza A viruses cause respiratory disease in humans with potentially fa...

journal_title：Cell research

authors： Neumann G,Chen H,Gao GF,Shu Y,Kawaoka Y

更新日期：2010-01-01 00:00:00

abstract：:Phytohormone abscisic acid (ABA) was critical for many plant growth and developmental processes including seed maturation, germination and response to environmental factors. With the purpose to detect the possible ABA related signal transduction pathways, we tried to isolate ABA-regulated genes through cDNA macroarray...

journal_title：Cell research

authors： Lin F,Xu SL,Ni WM,Chu ZQ,Xu ZH,Xue HW

更新日期：2003-02-01 00:00:00

abstract：:Vascular integrity helps maintain brain microenvironment homeostasis, which is critical for the normal development and function of the central nervous system. It is known that neural cells can regulate brain vascular integrity. However, due to the high complexity of neurovascular interactions involved, understanding o...

journal_title：Cell research

authors： Xu B,Zhang Y,Du XF,Li J,Zi HX,Bu JW,Yan Y,Han H,Du JL

更新日期：2017-07-01 00:00:00

abstract：:A wide variety of neurons and glial cells differentiate from common precursor cells in the developing nervous system. During this process, Notch-mediated cell-cell interaction is essential for maintenance of dividing cells and subsequent generation of cell type diversity. Activation of Notch inhibits cellular differen...

journal_title：Cell research

authors： Kageyama R,Ohtsuka T

更新日期：1999-09-01 00:00:00

abstract：:In order to analyze the mechanism of immuno-modulation by LPS on murine peritoneal suppressor macrophages, we have, using RNase protection assay, checked the changes of mRNA expression pattern of several cytokine genes during the immuno-modulation. It has been found that, after treating peritoneal suppressor macrophag...

journal_title：Cell research

authors： Feng WG,Chang ZL

更新日期：1998-12-01 00:00:00

abstract：:The 5' fragment (1 647 bp) of the cotton glucuronosyltransferase gene (GhGlcAT1) was transcriptionally fused to the beta-glucuronidase (GUS) gene, and functionally analyzed for important regulatory regions controlling gene expression in transgenic tobacco plants. GUS activity analysis revealed that the full-length pro...

journal_title：Cell research

authors： Wu AM,Lv SY,Liu JY

更新日期：2007-02-01 00:00:00

abstract：:Missense mutations in Leucine-Rich Repeat Kinase 2 (LRRK2) cause the majority of familial and some sporadic forms of Parkinson's disease (PD). The hyperactivity of LRRK2 kinase induced by the pathogenic mutations underlies neurotoxicity, promoting the development of LRRK2 kinase inhibitors as therapeutics. Many potent...

journal_title：Cell research

authors： Schaffner A,Li X,Gomez-Llorente Y,Leandrou E,Memou A,Clemente N,Yao C,Afsari F,Zhi L,Pan N,Morohashi K,Hua X,Zhou MM,Wang C,Zhang H,Chen SG,Elliott CJ,Rideout H,Ubarretxena-Belandia I,Yue Z

更新日期：2019-04-01 00:00:00

abstract：:Craniofacial anomalies (CFAs) characterized by birth defects of skull and facial bones are the most frequent congenital disease. Genomic analysis has identified multiple genes responsible for CFAs; however, the underlying genetic mechanisms for the majority of CFAs remain largely unclear. Our previous study revealed t...

journal_title：Cell research

authors： Shao R,Liu J,Yan G,Zhang J,Han Y,Guo J,Xu Z,Yuan Z,Liu J,Malumbres M,Wan L,Wei W,Zou W

更新日期：2016-06-01 00:00:00

abstract：:The authors apologized for the spelling mistake of author name for Zhengyu Ju. The correct form is Zhenyu Ju. We apologize for any hassle that may have been caused by our mistake. ...

journal_title：Cell research

authors： Li Y,Zhao H,Huang X,Tang J,Zhang S,Li Y,Liu X,He L,Ju Z,Lui KO,Zhou B

更新日期：2018-08-01 00:00:00