Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein.

abstract：:While M1 macrophages are highly pro-inflammatory and microbicidal, M2 macrophages and the related tumor associated macrophages (TAMs) regulate tissue remodeling and angiogenesis and can display immunomodulatory activity. In July issue of Cell Research, Zhang et al. show that ROS production, critical for the activation...

journal_title：Cell research

authors： Covarrubias A,Byles V,Horng T

更新日期：2013-08-01 00:00:00

abstract：:Facioscapulohumeral muscular dystrophy (FSHD) is a neuromuscular disorder often considered to be the third most common muscular dystrophy. Deletions reducing the copy number of the D4Z4 repeat in the distal end of the 4q arm are the main genetic cause of the disease. The recently highlighted research has identified a ...

journal_title：Cell research

authors： Vizoso M,Esteller M

更新日期：2012-10-01 00:00:00

abstract：:Mammalian target of rapamycin (mTOR) is a core component of raptor-mTOR (mTORC1) and rictor-mTOR (mTORC2) complexes that control diverse cellular processes. Both mTORC1 and mTORC2 regulate several elements downstream of type I insulin-like growth factor receptor (IGF-IR) and insulin receptor (InsR). However, it is unk...

journal_title：Cell research

authors： Yin Y,Hua H,Li M,Liu S,Kong Q,Shao T,Wang J,Luo Y,Wang Q,Luo T,Jiang Y

更新日期：2016-01-01 00:00:00

abstract：:Lineage conversion by expression of lineage-specific transcription factors is a process of epigenetic remodeling that has low efficiency. The mechanism by which a cell resists lineage conversion is largely unknown. Using hepatic-specific transcription factors Foxa3, Hnf1α and Gata4 (3TF) to induce hepatic conversion i...

journal_title：Cell research

authors： Ji S,Zhu L,Gao Y,Zhang X,Yan Y,Cen J,Li R,Zeng R,Liao L,Hou C,Gao Y,Gao S,Wei G,Hui L

更新日期：2017-05-01 00:00:00

abstract：:Elimination of misfolded proteins of the endoplasmic reticulum (ER) requires their retrotranslocation from the ER to the cytosol via membrane-bound ubiquitin ligase complexes. Baldridge and Rapoport now reconstitute a key step of retrotranslocation, demonstrating a protein conduit gated by ubiquitination. ...

journal_title：Cell research

authors： Zhang T,Ye Y

更新日期：2016-10-01 00:00:00

abstract：:Wor1 (white-opaque switching regulator 1) is a master regulator of the white-opaque switching in Candida albicans, an opportunistic human fungal pathogen, and is associated with its pathogenicity and commensality. Wor1 contains a conserved DNA-binding region at the N-terminus, consisting of two conserved segments (WOP...

journal_title：Cell research

authors： Zhang S,Zhang T,Yan M,Ding J,Chen J

更新日期：2014-09-01 00:00:00

abstract：:Eosinophils (Eos) have been long considered as end-stage effector cells in the hierarchical hematopoietic system. Numerous lines of evidence have suggested that Eos are multifunctional leukocytes with respect to the initiation, propagation and regulation of various inflammatory or immune reactions, especially in aller...

journal_title：Cell research

authors： Zhang C,Yi W,Li F,Du X,Wang H,Wu P,Peng C,Luo M,Hua W,Wong CC,Lee JJ,Li W,Chen Z,Ying S,Ju Z,Shen H

更新日期：2018-03-01 00:00:00

abstract：:Mammalian cell totipotency is a subject that has fascinated scientists for generations. A long lasting question whether some of the somatic cells retains totipotency was answered by the cloning of Dolly at the end of the 20th century. The dawn of the 21st has brought forward great expectations in harnessing the power ...

journal_title：Cell research

authors： Pan GJ,Chang ZY,Schöler HR,Pei D

更新日期：2002-12-01 00:00:00

abstract：:LRP16 was previously identified as an estrogen-induced gene in breast cancer cells. The responsiveness of LRP16 to estrogen and its functional effects in endometrial cancer (EC) cells are still unclear. Here, we show that the mRNA level and promoter activity of the LRP16 gene were significantly increased by 17beta-est...

journal_title：Cell research

authors： Meng YG,Han WD,Zhao YL,Huang K,Si YL,Wu ZQ,Mu YM

更新日期：2007-10-01 00:00:00

abstract：:Cytosine methylation of genomic DNA controls gene expression and maintains genome stability. How a specific DNA sequence is targeted for methylation by a methyltransferase is largely unknown. Here, we show that histone H3 tails lacking lysine 4 (K4) methylation function as an allosteric activator for methyltransferase...

journal_title：Cell research

authors： Li BZ,Huang Z,Cui QY,Song XH,Du L,Jeltsch A,Chen P,Li G,Li E,Xu GL

更新日期：2011-08-01 00:00:00

abstract：:Intracellular redox homeostasis plays a critical role in determining tumor cells' sensitivity to drug-induced apoptosis. Here we investigated the role of thioredoxin-1 (TRX1), a key component of redox regulation, in arsenic trioxide (As(2)O(3))-induced apoptosis. Over-expression of wild-type TRX1 in HepG(2) cells led ...

journal_title：Cell research

authors： Tian C,Gao P,Zheng Y,Yue W,Wang X,Jin H,Chen Q

更新日期：2008-04-01 00:00:00

abstract：:A paracrine regulation was recently proposed in human embryonic stem cells (hESCs) grown in mouse embryonic fibroblast (MEF)-conditioned media (MEF-CM), where hESCs spontaneously differentiate into autologous fibroblast-like cells to maintain culture homeostasis by producing TGF-beta and insulin-like growth factor-II ...

journal_title：Cell research

authors： Montes R,Ligero G,Sanchez L,Catalina P,de la Cueva T,Nieto A,Melen GJ,Rubio R,García-Castro J,Bueno C,Menendez P

更新日期：2009-06-01 00:00:00

abstract：:Critical epigenetic regulation of primate embryogenesis entails DNA methylome changes. Here we report genome-wide composition, patterning, and stage-specific dynamics of DNA methylation in pre-implantation rhesus monkey embryos as well as male and female gametes studied using an optimized tagmentation-based whole-geno...

journal_title：Cell research

authors： Gao F,Niu Y,Sun YE,Lu H,Chen Y,Li S,Kang Y,Luo Y,Si C,Yu J,Li C,Sun N,Si W,Wang H,Ji W,Tan T

更新日期：2017-04-01 00:00:00

abstract：:Atrial natriuretic peptide (ANP) is an important component of the natriuretic peptide system. A great role in many regulatory systems is played by mast cells. Meanwhile involvement of these cells in ANP activity is poorly studied. In this work, we have shown the presence of ANP in rat peritoneal mast cells. Pure fract...

journal_title：Cell research

authors： Martynova MG,Bystrova OA,Moiseeva OM,Evdonin AL,Kondratov KA,Medvedeva ND

更新日期：2005-10-01 00:00:00

abstract：:Apoptosis is a form of genetically programmed cell death, which plays a key role in regulation of cellularity in a variety of tissue and cell types including the cardiovascular tissues. Under both physiological and pathophysiological conditions, various biophysiological and biochemical factors, including mechanical fo...

journal_title：Cell research

authors： Geng YJ

更新日期：2001-12-01 00:00:00

abstract：:In mammals, the inheritance of mitochondrion and its DNA (mtDNA) is strictly maternal, despite the fact that a sperm can inject up to 100 functional mitochondria into the oocyte during fertilization. The mechanisms responsible for the elimination of the paternal mitochondria remain largely unknown. We report here that...

journal_title：Cell research

authors： Zhou Q,Li H,Xue D

更新日期：2011-12-01 00:00:00

abstract：:Kinesins are microtubule-based motors involved in various intracellular transports. Neurons, flagellated cells, and pigment cells have been traditionally used as model systems to study the cellular functions of kinesins. Here, we report silkworm posterior silkgland (PSG), specialized cells with an extensive endomembra...

journal_title：Cell research

authors： Wang Q,Teng J,Shen B,Zhang W,Guo Y,Su X,Zhang C,Yu AC,Chen J

更新日期：2010-06-01 00:00:00

abstract：:The pituitary adenylate cyclase-activating polypeptide type I receptor (PAC1R) belongs to the secretin receptor family and is widely distributed in the central neural system and peripheral organs. Abnormal activation of the receptor mediates trigeminovascular activation and sensitization, which is highly related to mi...

journal_title：Cell research

authors： Wang J,Song X,Zhang D,Chen X,Li X,Sun Y,Li C,Song Y,Ding Y,Ren R,Harrington EH,Hu LA,Zhong W,Xu C,Huang X,Wang HW,Ma Y

更新日期：2020-05-01 00:00:00

abstract：:We have developed a cell-free system that can trigger the nuclei purified from mouse liver and suspension-cultured carrot cells to undergo apoptosis as defined by the formation of apoptotic bodies and nucleosomal DNA fragments. The effects of different divalent cations and cycloheximide on DNA cleavage in this system ...

journal_title：Cell research

authors： Jiang ZF,Zhu S,Sun YL,Zhai ZH

更新日期：1999-06-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Cell research

authors： Wang MS,Thakur M,Peng MS,Jiang Y,Frantz LAF,Li M,Zhang JJ,Wang S,Peters J,Otecko NO,Suwannapoom C,Guo X,Zheng ZQ,Esmailizadeh A,Hirimuthugoda NY,Ashari H,Suladari S,Zein MSA,Kusza S,Sohrabi S,Kharrati-Koopaee H,

更新日期：2020-09-01 00:00:00

abstract：:International non-governmental organizations were among the first international actors that responded to the emergence of AIDS crisis in China. Since 1994, the number of international non-governmental organizations and charitable foundations working in AIDS related issue areas in China has grown steadily and substanti...

journal_title：Cell research

authors： Wu FS

更新日期：2005-11-01 00:00:00

abstract：:In mice treated with antibiotics to deplete commensal microbiota, there is a significant overhaul of host cellular disposition and function with CX3CR1+ mononuclear phagocytic cells carrying pathogenic and non-pathogenic administered bacteria to the (messenteric lymph node) MLN, resulting in T cell stimulation and IgA...

journal_title：Cell research

authors： Dasgupta S,Kasper DL

更新日期：2013-05-01 00:00:00

abstract：:A recent paper published in Nature reports sensory nerve fibers in the skin that give local immune cells important instructions for the organization of an immune response; in this particular case the cooperation between the nervous and immune systems had disastrous consequences, namely an auto-destruction of the skin....

journal_title：Cell research

authors： Odoardi F,Neuhuber W,Flügel A

更新日期：2014-09-01 00:00:00

abstract：:Entry into mitosis is driven by signaling cascades of mitotic kinases. Our recent studies show that TTK, a kinetochore-associated protein kinase, interacts with CENP-E, a mitotic kinesin located to corona fiber of kinetochore. Using immunoelectron microscopy, here we show that TTK is present at the nuclear pore adjace...

journal_title：Cell research

authors： Dou Z,Sawagechi A,Zhang J,Luo H,Brako L,Yao XB

更新日期：2003-12-01 00:00:00

abstract：:The first cell fate choice in the mammalian embryo, the segregation of the inner cell mass (ICM) and trophectoderm (TE), is regulated by the mutually antagonistic effects of the transcription factors, Oct4 and Cdx2, while the pluripotency factor, Nanog, is essential to specify the epiblast. We have analyzed the promot...

journal_title：Cell research

authors： Chen L,Yabuuchi A,Eminli S,Takeuchi A,Lu CW,Hochedlinger K,Daley GQ

更新日期：2009-09-01 00:00:00

abstract：:MSH5, a member of the MutS homolog DNA mismatch repair protein family, has been shown to be required for proper homologous chromosome recombination in diverse organisms such as mouse, budding yeast and Caenorhabditis elegans. In this paper, we show that a mutant Arabidopsis plant carrying the putative disrupted AtMSH5...

journal_title：Cell research

authors： Lu X,Liu X,An L,Zhang W,Sun J,Pei H,Meng H,Fan Y,Zhang C

更新日期：2008-05-01 00:00:00

abstract：:Calcium-dependent proteolytic calpains are implicated in a variety of physiological processes, as well as pathologies associated with calcium overload. However, the mechanism by which calpain is activated remains elusive since intracellular calcium levels under physiological conditions do not reach the high concentrat...

journal_title：Cell research

authors： Metwally E,Zhao G,Wang Q,Zhang YQ

更新日期：2020-08-26 00:00:00

abstract：:Postzygotic single-nucleotide mutations (pSNMs) have been studied in cancer and a few other overgrowth human disorders at whole-genome scale and found to play critical roles. However, in clinically unremarkable individuals, pSNMs have never been identified at whole-genome scale largely due to technical difficulties an...

journal_title：Cell research

authors： Huang AY,Xu X,Ye AY,Wu Q,Yan L,Zhao B,Yang X,He Y,Wang S,Zhang Z,Gu B,Zhao HQ,Wang M,Gao H,Gao G,Zhang Z,Yang X,Wu X,Zhang Y,Wei L

更新日期：2014-11-01 00:00:00

abstract：:Craniofacial anomalies (CFAs) characterized by birth defects of skull and facial bones are the most frequent congenital disease. Genomic analysis has identified multiple genes responsible for CFAs; however, the underlying genetic mechanisms for the majority of CFAs remain largely unclear. Our previous study revealed t...

journal_title：Cell research

authors： Shao R,Liu J,Yan G,Zhang J,Han Y,Guo J,Xu Z,Yuan Z,Liu J,Malumbres M,Wan L,Wei W,Zou W

更新日期：2016-06-01 00:00:00

abstract：:A recent study led by Professor Rob Martienssen in Cell showed that 3'-tRNA-derived small RNAs can suppress long terminal repeat retrotransposon activity in mammalian cells by mechanisms independent of DNA-associated epigenetic marks, suggesting how the genome may defend itself from retrotransposon invasion during epi...

journal_title：Cell research

authors： Zhang Y,Shi J,Chen Q

更新日期：2017-11-01 00:00:00