Abstract:
:Classical methyl-CpG binding proteins contain the conserved DNA binding motif methyl-cytosine binding domain (MBD), which preferentially binds to methylated CpG dinucleotides. These proteins serve as transcriptional repressors, mediating gene silencing via DNA cytosine methylation. Mutations in methyl-CpG binding protein 2 (MeCP2) have been linked to the human mental retardation disorder Rett syndrome, suggesting an important role for methyl-CpG binding proteins in brain development and function. This mini-review summarizes the recent advances in studying the diverse functions of MeCP2 as a prototype for other methyl-CpG binding proteins in the development and function of the vertebrate nervous system.
journal_name
Cell Resjournal_title
Cell researchauthors
Fan G,Hutnick Ldoi
10.1038/sj.cr.7290294keywords:
subject
Has Abstractpub_date
2005-04-01 00:00:00pages
255-61issue
4eissn
1001-0602issn
1748-7838journal_volume
15pub_type
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