Abstract:
:SRC-3/AIB1 (steroid receptor coactivator 3/amplified in breast cancer 1) is an authentic oncogene that contributes to the development of drug resistance and poor disease-free survival in cancer patients. Autophagy is also an important cell death mechanism that has tumor suppressor function. In this study, we identified macrophage migration inhibitory factor (MIF) as a novel target gene of SRC-3 and demonstrated its importance in cell survival. Specifically, we showed that MIF is a strong suppressor of autophagic cell death. We further showed that suppression of MIF, in turn, induced autophagic cell death, enhanced chemosensitivity and inhibited tumorigenesis in a xenograft mouse tumorigenesis model. Our study demonstrated that regulation of MIF expression and suppression of autophagic cell death is a potent mechanism by which SRC-3 contributes to increased chemoresistance and tumorigenicity.
journal_name
Cell Resjournal_title
Cell researchauthors
Wu MY,Fu J,Xu J,O'Malley BW,Wu RCdoi
10.1038/cr.2012.44subject
Has Abstractpub_date
2012-06-01 00:00:00pages
1003-21issue
6eissn
1001-0602issn
1748-7838pii
cr201244journal_volume
22pub_type
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