Probing hepatocyte heterogeneity.

abstract：:Vascular integrity helps maintain brain microenvironment homeostasis, which is critical for the normal development and function of the central nervous system. It is known that neural cells can regulate brain vascular integrity. However, due to the high complexity of neurovascular interactions involved, understanding o...

journal_title：Cell research

authors： Xu B,Zhang Y,Du XF,Li J,Zi HX,Bu JW,Yan Y,Han H,Du JL

更新日期：2017-07-01 00:00:00

abstract：:Inflammasomes are multi-component signaling complexes critical to the initiation of pyroptotic cell death in response to invading pathogens and cellular damage. A number of innate immune receptors have been reported to serve as inflammasome sensors. Activation of these sensors leads to the proteolytic activation of ca...

journal_title：Cell research

authors： Christgen S,Place DE,Kanneganti TD

更新日期：2020-04-01 00:00:00

abstract：:Wnt/β-catenin signaling is essential for the initiation of dorsal-ventral patterning during vertebrate embryogenesis. Maternal β-catenin accumulates in dorsal marginal nuclei during cleavage stages, but its critical target genes essential for dorsalization are silent until mid-blastula transition (MBT). Here, we find ...

journal_title：Cell research

authors： Wei S,Dai M,Liu Z,Ma Y,Shang H,Cao Y,Wang Q

更新日期：2017-02-01 00:00:00

abstract：:circRNAs arise from back splicing events during mRNA processing, and when deregulated can play an active role in cancer. Here we characterize a new circRNA (circPOK) encoded by the Zbtb7a gene (also kown as POKEMON, LRF) in the context of mesenchymal tumor progression. circPOK functions as a non-coding proto-oncogenic...

journal_title：Cell research

authors： Guarnerio J,Zhang Y,Cheloni G,Panella R,Mae Katon J,Simpson M,Matsumoto A,Papa A,Loretelli C,Petri A,Kauppinen S,Garbutt C,Nielsen GP,Deshpande V,Castillo-Martin M,Cordon-Cardo C,Dimitrios S,Clohessy JG,Batish M,Pan

更新日期：2019-08-01 00:00:00

abstract：:SRC-3/AIB1 (steroid receptor coactivator 3/amplified in breast cancer 1) is an authentic oncogene that contributes to the development of drug resistance and poor disease-free survival in cancer patients. Autophagy is also an important cell death mechanism that has tumor suppressor function. In this study, we identifie...

journal_title：Cell research

authors： Wu MY,Fu J,Xu J,O'Malley BW,Wu RC

更新日期：2012-06-01 00:00:00

abstract：:Over the past four years, the field of the innate immune response has been highly influenced by the discovery of the IkappaB kinase (IKK)-related kinases, TANK Binding Kinase 1 (TBK1) and IKKi, which regulate the activity of interferon regulatory factor (IRF)-3/IRF-7 and NF-kappaB transcription factors. More recently,...

journal_title：Cell research

authors： Clément JF,Meloche S,Servant MJ

更新日期：2008-09-01 00:00:00

abstract：:The Wnt/β-catenin pathway plays important roles in the differentiation of multiple cell types, including mesenchymal stem cells. Using a cell-based chemical screening assay with a synthetic chemical library of 270 000 compounds, we identified the compound SKL2001 as a novel agonist of the Wnt/β-catenin pathway and unc...

journal_title：Cell research

authors： Gwak J,Hwang SG,Park HS,Choi SR,Park SH,Kim H,Ha NC,Bae SJ,Han JK,Kim DE,Cho JW,Oh S

更新日期：2012-01-01 00:00:00

abstract：:The year of 2013 marked the 50th anniversary of C de Duve's coining of the term "autophagy" for the degradation process of cytoplasmic constituents in the lysosome/vacuole. This year we regretfully lost this great scientist, who contributed much during the early years of research to the field of autophagy. Soon after ...

journal_title：Cell research

authors： Ohsumi Y

更新日期：2014-01-01 00:00:00

abstract：:Polymerase I and transcript release factor (PTRF, also known as Cavin-1) is an essential component in the biogenesis and function of caveolae. Here, we show that PTRF expression is increased in senescent human fibroblasts. Importantly, overexpression of PTRF induced features characteristic of cellular senescence, wher...

journal_title：Cell research

authors： Bai L,Deng X,Li J,Wang M,Li Q,An W,A D,Cong YS

更新日期：2011-07-01 00:00:00

abstract：:Interactions are the essence of all biomolecules because they cannot fulfill their roles without interacting with other molecules. Hence, mapping the interactions of biomolecules can be useful for understanding their roles and functions. Furthermore, the development of molecular based systems biology requires an under...

journal_title：Cell research

authors： Figeys D

更新日期：2008-07-01 00:00:00

abstract：:The MyD88-independent pathway, one of the two crucial TLR signaling routes, is thought to be a vertebrate innovation. However, a novel Toll/interleukin-1 receptor (TIR) adaptor, designated bbtTICAM, which was identified in the basal chordate amphioxus, links this pathway to invertebrates. The protein architecture of b...

journal_title：Cell research

authors： Yang M,Yuan S,Huang S,Li J,Xu L,Huang H,Tao X,Peng J,Xu A

更新日期：2011-10-01 00:00:00

abstract：:Brassinosteroids (BRs) are essential steroid hormones that have crucial roles in plant growth and development. BRs are perceived by the cell-surface receptor-like kinase brassinosteroid insensitive 1 (BRI1). In the absence of BRs, the cytosolic kinase domain (KD) of BRI1 is inhibited by its auto-inhibitory carboxyl te...

journal_title：Cell research

authors： Wang J,Jiang J,Wang J,Chen L,Fan SL,Wu JW,Wang X,Wang ZX

更新日期：2014-11-01 00:00:00

abstract：:Mitogen-activated protein kinase (MAPK) cascades play important roles in regulating plant innate immune responses. In a genetic screen to search for mutants with constitutive defense responses, we identified multiple alleles of mpk4 and mekk1 that exhibit cell death and constitutive defense responses. Bimolecular fluo...

journal_title：Cell research

authors： Gao M,Liu J,Bi D,Zhang Z,Cheng F,Chen S,Zhang Y

更新日期：2008-12-01 00:00:00

abstract：:Since its discovery in 1989, researchers strive after a small animal model for Hepatitis C virus infection, so far with very limited success. A study recently published in Nature now for the first time reports the recapitulation of the complete life cycle of this virus in inbred mice with a functional adaptive immune ...

journal_title：Cell research

authors： Binder M,Bartenschlager R

更新日期：2013-12-01 00:00:00

abstract：:Exosome-mediated intercellular communication has become an emerging field of human health and diseases. A recent study published by Cell Research reports that in zebrafish neurons can remotely regulate blood-brain barrier integrity by delivering miR-132 through secretion of exosomes. ...

journal_title：Cell research

authors： Zhao Z,Zlokovic BV

更新日期：2017-07-01 00:00:00

abstract：:Hedgehog (Hh) signaling plays vital roles in animal development and tissue homeostasis, and its misregulation causes congenital diseases and several types of cancer. Suppressor of Fused (Su(fu)) is a conserved inhibitory component of the Hh signaling pathway, but how it is regulated remains poorly understood. Here we ...

journal_title：Cell research

authors： Liu C,Zhou Z,Yao X,Chen P,Sun M,Su M,Chang C,Yan J,Jiang J,Zhang Q

更新日期：2014-05-01 00:00:00

abstract：:Type I interferon (IFN-I) production is efficiently induced to ensure a potent innate immune response to viral infection. How this response can be enhanced, however, remains to be explored. Here, we identify a new cytoplasmic long non-coding RNA (lncRNA), lncLrrc55-AS, that drives a positive feedback loop to promote i...

journal_title：Cell research

authors： Zhou Y,Li M,Xue Y,Li Z,Wen W,Liu X,Ma Y,Zhang L,Shen Z,Cao X

更新日期：2019-08-01 00:00:00

abstract：:The endoplasmic reticulum (ER) is composed of the nuclear envelope, perinuclear sheets and a peripheral tubular network. The peripheral ER and mitochondria form tight contacts at specific subdomains, which coordinate the functions of the two organelles and are required for multiple cellular processes such as Ca2+ tran...

journal_title：Cell research

authors： Zheng P,Chen Q,Tian X,Qian N,Chai P,Liu B,Hu J,Blackstone C,Zhu D,Teng J,Chen J

更新日期：2018-08-01 00:00:00

abstract：:Members of the basic helix-loop-helix (bHLH) gene family play important roles in vertebrate neurogenesis. In this study, confocal microscopy-based fluorescence resonance energy transfer (FRET) is used to monitor bHLH protein-protein interactions under various physiological conditions. Tissue-specific bHLH activators, ...

journal_title：Cell research

authors： Wang C,Bian W,Xia C,Zhang T,Guillemot F,Jing N

更新日期：2006-06-01 00:00:00

abstract：:Aging is associated with many complex diseases. Reliable prediction of the aging process is important for assessing the risks of aging-associated diseases. However, despite intense research, so far there is no reliable aging marker. Here we addressed this problem by examining whether human 3D facial imaging features c...

journal_title：Cell research

authors： Chen W,Qian W,Wu G,Chen W,Xian B,Chen X,Cao Y,Green CD,Zhao F,Tang K,Han JD

更新日期：2015-05-01 00:00:00

abstract：:DNA replication stress, a feature of human cancers, often leads to instability at specific genomic loci, such as the common fragile sites (CFSs). Cells experiencing DNA replication stress may also exhibit mitotic DNA synthesis (MiDAS). To understand the physiological function of MiDAS and its relationship to CFSs, we ...

journal_title：Cell research

authors： Macheret M,Bhowmick R,Sobkowiak K,Padayachy L,Mailler J,Hickson ID,Halazonetis TD

更新日期：2020-11-01 00:00:00

abstract：:Cellular biological activities are tightly controlled by intracellular signaling processes initiated by extracellular signals. Protein tyrosine phosphatases, which remove phosphate groups from phosphorylated signaling molecules, play equally important tyrosine roles as protein tyrosine kinases in signal transduction. ...

journal_title：Cell research

authors： Qu CK

更新日期：2000-12-01 00:00:00

abstract：:Elimination of misfolded proteins of the endoplasmic reticulum (ER) requires their retrotranslocation from the ER to the cytosol via membrane-bound ubiquitin ligase complexes. Baldridge and Rapoport now reconstitute a key step of retrotranslocation, demonstrating a protein conduit gated by ubiquitination. ...

journal_title：Cell research

authors： Zhang T,Ye Y

更新日期：2016-10-01 00:00:00

abstract：:The tumor suppressor PTEN controls a variety of biological processes including cell proliferation, growth, migration, and death. As a master cellular regulator, PTEN itself is also subjected to deliberated regulation to ensure its proper function. Defects in PTEN regulation have a profound impact on carcinogenesis. In...

journal_title：Cell research

authors： Wang X,Jiang X

更新日期：2008-08-01 00:00:00

abstract：:Gonad development requires a coordinated soma-germline interaction that ensures renewal and differentiation of germline and somatic stem cells to ultimately produce mature gametes. The Drosophila tumour suppressor gene discs large (dlg) encodes a septate junction protein functioning during epithelial polarization, asy...

journal_title：Cell research

authors： Papagiannouli F,Mechler BM

更新日期：2009-10-01 00:00:00

abstract：:Ferroptosis is an iron-dependent form of regulated necrosis. It is implicated in various human diseases, including ischemic organ damage and cancer. Here, we report the crucial role of autophagy, particularly autophagic degradation of cellular iron storage proteins (a process known as ferritinophagy), in ferroptosis. ...

journal_title：Cell research

authors： Gao M,Monian P,Pan Q,Zhang W,Xiang J,Jiang X

更新日期：2016-09-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Cell research

authors： Wang MS,Thakur M,Peng MS,Jiang Y,Frantz LAF,Li M,Zhang JJ,Wang S,Peters J,Otecko NO,Suwannapoom C,Guo X,Zheng ZQ,Esmailizadeh A,Hirimuthugoda NY,Ashari H,Suladari S,Zein MSA,Kusza S,Sohrabi S,Kharrati-Koopaee H,

更新日期：2020-09-01 00:00:00

abstract：:While N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic mRNA, is linked to cell differentiation and tissue development, the biological significance of m6A modification in mammalian glial development remains unknown. Here, we identify a novel m6A reader, Prrc2a (Proline rich coiled-coil 2 ...

journal_title：Cell research

authors： Wu R,Li A,Sun B,Sun JG,Zhang J,Zhang T,Chen Y,Xiao Y,Gao Y,Zhang Q,Ma J,Yang X,Liao Y,Lai WY,Qi X,Wang S,Shu Y,Wang HL,Wang F,Yang YG,Yuan Z

更新日期：2019-01-01 00:00:00

abstract：:Morphologically, caveolae and lipid rafts are two different membrane structures. They are often reported to share similar lipid and protein compositions, and are considered to be two subtypes of membrane lipid microdomains. By modifying sucrose density gradient flotation centrifugation, which is used to isolate lipid ...

journal_title：Cell research

authors： Yao Y,Hong S,Zhou H,Yuan T,Zeng R,Liao K

更新日期：2009-04-01 00:00:00

abstract：:Protein ubiquitination by E3 ubiquitin ligases plays an important role in cancer development. In this study, we provide experimental evidence that a RING-finger-containing protein RNF13 is an ER/Golgi membrane-associated E3 ubiquitin ligase and its RING finger domain is required for the ubiquitin ligase activity. Immu...

journal_title：Cell research

authors： Zhang Q,Meng Y,Zhang L,Chen J,Zhu D

更新日期：2009-03-01 00:00:00