Ferroptosis is an autophagic cell death process.

abstract：:Endothelial progenitor cells (EPCs) participate in the processes of postnatal neovascularization and re-endothelialization in response to tissue ischemia and endothelial injury. The level of EPCs present has been found to be directly associated with the outcome of cardiovascular diseases, and could be regulated by sti...

journal_title：Cell research

authors： Yin T,Ma X,Zhao L,Cheng K,Wang H

更新日期：2008-07-01 00:00:00

abstract：:There are remarkable disparities among patients of different races with prostate cancer; however, the mechanism underlying this difference remains unclear. Here, we present a comprehensive landscape of the transcriptome profiles of 14 primary prostate cancers and their paired normal counterparts from the Chinese popul...

journal_title：Cell research

authors： Ren S,Peng Z,Mao JH,Yu Y,Yin C,Gao X,Cui Z,Zhang J,Yi K,Xu W,Chen C,Wang F,Guo X,Lu J,Yang J,Wei M,Tian Z,Guan Y,Tang L,Xu C,Wang L,Gao X,Tian W,Wang J,Yang H,Wang J,Sun Y

更新日期：2012-05-01 00:00:00

abstract：:Recent evidence indicates that codon optimality is a broad determinant of mRNA stability. A study by Radhakrishnan et al. in Cell raises the possibility that the conserved DEAD-box protein Dhh1 underlies the phenomenon. ...

journal_title：Cell research

authors： Harigaya Y,Parker R

更新日期：2016-12-01 00:00:00

abstract：:A monoclonal antibody, LC-1, recognizing lung cancer associated common antigens was obtained in authors' laboratory. Its single chain Fv fragment (ScFv) named LC-1 ScFv was constructed based on recombinant phage displayed techniques. For expression on cell membrane, LC-1 ScFv was cloned into pDisplay vector, which dir...

journal_title：Cell research

authors： Chen L,Li G,Tang L,Wang J,Ge XR

更新日期：2002-03-01 00:00:00

abstract：:Recent studies on enzymes and reader proteins for histone crotonylation support a function of histone crotonylation in transcription. However, the enzyme(s) responsible for histone decrotonylation (HDCR) remains poorly defined. Moreover, it remains to be determined if histone crotonylation is physiologically significa...

journal_title：Cell research

authors： Wei W,Liu X,Chen J,Gao S,Lu L,Zhang H,Ding G,Wang Z,Chen Z,Shi T,Li J,Yu J,Wong J

更新日期：2017-07-01 00:00:00

abstract：:While studying the neural precursor cell intermediate filament protein known as nestin in the developing mouse brain, we observed a strong cross-reaction of our nestin antibody with a 50 kDa protein that appeared on embryonic day 10 and continued to accumulate until postnatal day 1. Here we report evidence that this p...

journal_title：Cell research

authors： Kong LW,Ding XY,Kitani H,Shiurba R,Jing NH

更新日期：1999-12-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Cell research

authors： Ma M,Liu JJ,Li Y,Huang Y,Ta N,Chen Y,Fu H,Ye MD,Ding Y,Huang W,Wang J,Dong MQ,Yu L,Wang HW

更新日期：2020-06-01 00:00:00

abstract：:The TGF-beta superfamily members have important roles in controlling patterning and tissue formation in both invertebrates and vertebrates. Two types of signal transducers, receptors and Smads, mediate the signaling to regulate expression of their target genes. Despite of the relatively simple signal transduction path...

journal_title：Cell research

authors： Chen YG,Meng AM

更新日期：2004-12-01 00:00:00

abstract：:Mechanical deformability is known to increase during cancer progression. Now Ma et al. identify a therapeutic strategy that targets deformable cells by microparticle-based drug delivery. ...

journal_title：Cell research

authors： Hamann J,Overholtzer M

更新日期：2016-06-01 00:00:00

abstract：:Ruptured and intact plasma membranes are classically considered as hallmarks of necrotic and apoptotic cell death, respectively. As such, apoptosis is usually considered a non-inflammatory process while necrosis triggers inflammation. Recent studies on necroptosis and pyroptosis, two types of programmed necrosis, reve...

journal_title：Cell research

authors： Zhang Y,Chen X,Gueydan C,Han J

更新日期：2018-01-01 00:00:00

abstract：:Accumulating evidence indicates that the mesenchymal-epithelial transition (MET) and epithelial-mesenchymal transition (EMT) are basic mechanisms for cell fate conversion and may help us understand both physiologic and pathologic processes such as development and carcinogenesis. Here, we further suggest that mammalian...

journal_title：Cell research

authors： Zheng H,Hutchins AP,Pan G,Li Y,Pei D,Pei G

更新日期：2014-10-01 00:00:00

abstract：:We have developed a cell-free system that can trigger the nuclei purified from mouse liver and suspension-cultured carrot cells to undergo apoptosis as defined by the formation of apoptotic bodies and nucleosomal DNA fragments. The effects of different divalent cations and cycloheximide on DNA cleavage in this system ...

journal_title：Cell research

authors： Jiang ZF,Zhu S,Sun YL,Zhai ZH

更新日期：1999-06-01 00:00:00

abstract：:Why stem cell numbers decline with age is a major question in regenerative biology and medicine. Skeletal muscle has emerged as a powerful paradigm to address this issue. Recently, genetic and cell marking strategies were used to uncover a new and causal relationship between muscle stem cells and differentiated fibers...

journal_title：Cell research

authors： Tajbakhsh S

更新日期：2013-04-01 00:00:00

abstract：:Neural crest (NC) cells are a migratory cell population synonymous with vertebrate evolution. They generate a wide variety of cell and tissue types during embryonic and adult development including cartilage and bone, connective tissue, pigment and endocrine cells as well as neurons and glia amongst many others. Such i...

journal_title：Cell research

authors： Achilleos A,Trainor PA

更新日期：2012-02-01 00:00:00

abstract：:Recent outbreaks of Zika virus (ZIKV) highlight an urgent need for therapeutics. The protease complex NS2B-NS3 plays essential roles during flaviviral polyprotein processing, and thus represents an attractive drug target. Here, we developed a split luciferase complementation-based high-throughput screening assay to id...

journal_title：Cell research

authors： Li Z,Brecher M,Deng YQ,Zhang J,Sakamuru S,Liu B,Huang R,Koetzner CA,Allen CA,Jones SA,Chen H,Zhang NN,Tian M,Gao F,Lin Q,Banavali N,Zhou J,Boles N,Xia M,Kramer LD,Qin CF,Li H

更新日期：2017-08-01 00:00:00

abstract：:Transforming growth factor beta (TGF-beta) carries out tumor suppressor activity in epithelial and lymphoid cells, whereas telomerase is required for most cancers. Although the molecular mechanisms by which TGF-beta acts as a tumor suppressor are yet to be fully established, a link between TGFb and its tumor suppresso...

journal_title：Cell research

authors： Li H,Xu D,Toh BH,Liu JP

更新日期：2006-02-01 00:00:00

abstract：:Atrial natriuretic peptide (ANP) is an important component of the natriuretic peptide system. A great role in many regulatory systems is played by mast cells. Meanwhile involvement of these cells in ANP activity is poorly studied. In this work, we have shown the presence of ANP in rat peritoneal mast cells. Pure fract...

journal_title：Cell research

authors： Martynova MG,Bystrova OA,Moiseeva OM,Evdonin AL,Kondratov KA,Medvedeva ND

更新日期：2005-10-01 00:00:00

abstract：:Long-range chromatin interactions between enhancers and promoters are essential for transcription of many developmentally controlled genes in mammals and other metazoans. Currently, the exact mechanisms that connect distal enhancers to their specific target promoters remain to be fully elucidated. Here, we show that t...

journal_title：Cell research

authors： Yan J,Chen SA,Local A,Liu T,Qiu Y,Dorighi KM,Preissl S,Rivera CM,Wang C,Ye Z,Ge K,Hu M,Wysocka J,Ren B

更新日期：2018-02-01 00:00:00

abstract：:Mammalian target of rapamycin (mTOR) is a core component of raptor-mTOR (mTORC1) and rictor-mTOR (mTORC2) complexes that control diverse cellular processes. Both mTORC1 and mTORC2 regulate several elements downstream of type I insulin-like growth factor receptor (IGF-IR) and insulin receptor (InsR). However, it is unk...

journal_title：Cell research

authors： Yin Y,Hua H,Li M,Liu S,Kong Q,Shao T,Wang J,Luo Y,Wang Q,Luo T,Jiang Y

更新日期：2016-01-01 00:00:00

abstract：:The neurodegenerative polyglutamine diseases are caused by an expansion of unstable polyglutamine repeats in various disease proteins. Although these mutant proteins are expressed ubiquitously in neuronal and non-neuronal cells, they cause selective degeneration of specific neuronal populations. Recently, increasing e...

journal_title：Cell research

authors： Bradford JW,Li S,Li XJ

更新日期：2010-04-01 00:00:00

abstract：:The study of the proteins that bind to telomeric DNA in mammals has provided a deep understanding of the mechanisms involved in chromosome-end protection. However, very little is known on the binding of these proteins to nontelomeric DNA sequences. The TTAGGG DNA repeat proteins 1 and 2 (TRF1 and TRF2) bind to mammali...

journal_title：Cell research

authors： Simonet T,Zaragosi LE,Philippe C,Lebrigand K,Schouteden C,Augereau A,Bauwens S,Ye J,Santagostino M,Giulotto E,Magdinier F,Horard B,Barbry P,Waldmann R,Gilson E

更新日期：2011-07-01 00:00:00

abstract：:The non-canonical inflammasome triggers host cell death and inflammation upon recognition of cytosolic LPS. A recent report in Cell now shows that Outer Membrane Vesicles (OMVs) of extracellular Gram-negative bacteria can deliver LPS into the host cell cytosol. ...

journal_title：Cell research

authors： Broz P

更新日期：2016-08-01 00:00:00

abstract：:In mice treated with antibiotics to deplete commensal microbiota, there is a significant overhaul of host cellular disposition and function with CX3CR1+ mononuclear phagocytic cells carrying pathogenic and non-pathogenic administered bacteria to the (messenteric lymph node) MLN, resulting in T cell stimulation and IgA...

journal_title：Cell research

authors： Dasgupta S,Kasper DL

更新日期：2013-05-01 00:00:00

abstract：:Skeletal muscle fitness and plasticity is an important determinant of human health and disease. Mitochondria are essential for maintaining skeletal muscle energy homeostasis by adaptive re-programming to meet the demands imposed by a myriad of physiologic or pathophysiological stresses. Skeletal muscle mitochondrial d...

journal_title：Cell research

authors： Gan Z,Fu T,Kelly DP,Vega RB

更新日期：2018-10-01 00:00:00

abstract：:While N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic mRNA, is linked to cell differentiation and tissue development, the biological significance of m6A modification in mammalian glial development remains unknown. Here, we identify a novel m6A reader, Prrc2a (Proline rich coiled-coil 2 ...

journal_title：Cell research

authors： Wu R,Li A,Sun B,Sun JG,Zhang J,Zhang T,Chen Y,Xiao Y,Gao Y,Zhang Q,Ma J,Yang X,Liao Y,Lai WY,Qi X,Wang S,Shu Y,Wang HL,Wang F,Yang YG,Yuan Z

更新日期：2019-01-01 00:00:00

abstract：:The year of 2013 marked the 50th anniversary of C de Duve's coining of the term "autophagy" for the degradation process of cytoplasmic constituents in the lysosome/vacuole. This year we regretfully lost this great scientist, who contributed much during the early years of research to the field of autophagy. Soon after ...

journal_title：Cell research

authors： Ohsumi Y

更新日期：2014-01-01 00:00:00

abstract：:CCAAT/enhancer binding protein alpha (C/EBPalpha) is a transcriptional regulatory factor that inhibits cell proliferation, and alternative translational initiation produces two polypeptides, C/EBPalphap30 and C/EBPalphap42. By expression profiling, it was revealed that C/EBPalphap30 specifically inhibited a unique set...

journal_title：Cell research

authors： Wang C,Chen X,Wang Y,Gong J,Hu G

更新日期：2007-04-01 00:00:00

abstract：:Facioscapulohumeral muscular dystrophy (FSHD) is a neuromuscular disorder often considered to be the third most common muscular dystrophy. Deletions reducing the copy number of the D4Z4 repeat in the distal end of the 4q arm are the main genetic cause of the disease. The recently highlighted research has identified a ...

journal_title：Cell research

authors： Vizoso M,Esteller M

更新日期：2012-10-01 00:00:00

abstract：:The full-length cDNA of Pinellia ternata agglutinin (PTA) was cloned from inflorescences using RACE-PCR. Through comparative analysis of PTA gene (pta) and its deduced amino acid sequence with those of other Araceae species, pta was found to encode a precursor lectin with signal peptide and to have extensive homology ...

journal_title：Cell research

authors： Yao JH,Zhao XY,Liao ZH,Lin J,Chen ZH,Chen F,Song J,Sun XF,Tang KX

更新日期：2003-08-01 00:00:00

abstract：:DNA double-strand breaks (DSBs) are introduced in cells by ionizing radiation and reactive oxygen species. In addition, they are commonly generated during V(D)J recombination, an essential aspect of the developing immune system. Failure to effectively repair these DSBs can result in chromosome breakage, cell death, on...

journal_title：Cell research

authors： Weterings E,Chen DJ

更新日期：2008-01-01 00:00:00