Abstract:
:The tumor suppressor PTEN controls a variety of biological processes including cell proliferation, growth, migration, and death. As a master cellular regulator, PTEN itself is also subjected to deliberated regulation to ensure its proper function. Defects in PTEN regulation have a profound impact on carcinogenesis. In this review, we briefly discuss recent advances concerning PTEN regulation and how such knowledge facilitates our understanding and further exploration of PTEN biology. The carboxyl-tail of PTEN, which appears to be associated with multiple types of posttranslational regulation, will be under detailed scrutiny. Further, a comparative analysis of PTEN and p53 suggests while p53 needs to be activated to suppress tumorigenesis (a dormant gatekeeper), PTEN is probably a constitutive surveillant against cancer development, thus a default gatekeeper.
journal_name
Cell Resjournal_title
Cell researchauthors
Wang X,Jiang Xdoi
10.1038/cr.2008.83subject
Has Abstractpub_date
2008-08-01 00:00:00pages
807-16issue
8eissn
1001-0602issn
1748-7838pii
cr200883journal_volume
18pub_type
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