Abstract:
:RIG-I belongs to a type of intracellular pattern recognition receptors involved in the recognition of viral RNA by the innate immune system. A report by Peisley et al. published in Nature provides the crystal structure of human RIG-I revealing a tetrameric architecture of the RIG-I 2-CARD domain bound by three K63-linked ubiquitin chains, uncovering its activation mechanism for downstream signaling.
journal_name
Cell Resjournal_title
Cell researchauthors
Zhu S,Jackson R,Flavell RAdoi
10.1038/cr.2014.58subject
Has Abstractpub_date
2014-06-01 00:00:00pages
645-6issue
6eissn
1001-0602issn
1748-7838pii
cr201458journal_volume
24pub_type
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