Abstract:
:Paramyxoviruses evade antiviral immune response using a small nonstructural protein, V, which binds to the host dsRNA sensor MDA5 and prevents it from activating the interferon signaling pathway. A recent crystal structure of the V protein in complex with MDA5, published in Science, revealed that V disrupts the structure of MDA5 and is integrated into the MDA5 protein fold, providing an intriguing new example of viral mimicry as a countermeasure against the host immune system.
journal_name
Cell Resjournal_title
Cell researchauthors
Wu B,Hur Sdoi
10.1038/cr.2013.32subject
Has Abstractpub_date
2013-06-01 00:00:00pages
735-6issue
6eissn
1001-0602issn
1748-7838pii
cr201332journal_volume
23pub_type
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