Abstract:
:The thymus provides the essential microenvironment for T-cell development and maturation. Thymic epithelial cells (TECs), which are composed of thymic cortical epithelial cells (cTECs) and thymic medullary epithelial cells (mTECs), have been well documented to be critical for these tightly regulated processes. It has long been controversial whether the common progenitor cells of TECs could give rise to both cTECs and mTECs. Great progress has been made to characterize the common TEC progenitor cells in recent years. We herein discuss the sole origin paradigm with regard to TEC differentiation as well as these progenitor cells in thymus regeneration.
journal_name
Cell Resjournal_title
Cell researchauthors
Zhang L,Sun L,Zhao Ydoi
10.1038/sj.cr.7310114subject
Has Abstractpub_date
2007-01-01 00:00:00pages
50-5issue
1eissn
1001-0602issn
1748-7838pii
7310114journal_volume
17pub_type
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