DNA damage-induced cell death: lessons from the central nervous system.

Abstract:

:DNA damage can, but does not always, induce cell death. While several pathways linking DNA damage signals to mitochondria-dependent and -independent death machineries have been elucidated, the connectivity of these pathways is subject to regulation by multiple other factors that are not well understood. We have proposed two conceptual models to explain the delayed and variable cell death response to DNA damage: integrative surveillance versus autonomous pathways. In this review, we discuss how these two models may explain the in vivo regulation of cell death induced by ionizing radiation (IR) in the developing central nervous system, where the death response is regulated by radiation dose, cell cycle status and neuronal development.

journal_name

Cell Res

journal_title

Cell research

authors

Borges HL,Linden R,Wang JY

doi

10.1038/cr.2007.110

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

17-26

issue

1

eissn

1001-0602

issn

1748-7838

pii

cr2007110

journal_volume

18

pub_type

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