Abstract:
:DNA damage can, but does not always, induce cell death. While several pathways linking DNA damage signals to mitochondria-dependent and -independent death machineries have been elucidated, the connectivity of these pathways is subject to regulation by multiple other factors that are not well understood. We have proposed two conceptual models to explain the delayed and variable cell death response to DNA damage: integrative surveillance versus autonomous pathways. In this review, we discuss how these two models may explain the in vivo regulation of cell death induced by ionizing radiation (IR) in the developing central nervous system, where the death response is regulated by radiation dose, cell cycle status and neuronal development.
journal_name
Cell Resjournal_title
Cell researchauthors
Borges HL,Linden R,Wang JYdoi
10.1038/cr.2007.110subject
Has Abstractpub_date
2008-01-01 00:00:00pages
17-26issue
1eissn
1001-0602issn
1748-7838pii
cr2007110journal_volume
18pub_type
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