Abstract:
:Hyaluronan binding protein 1 (HABP1) is a negatively charged multifunctional mammalian protein with a unique structural fold. Despite the fact that HABP1 possesses mitochondrial localization signal, it has also been localized to other cellular compartments. Using indirect immunofluorescence, we examined the sub-cellular localization of HABP1 and its dynamics during mitosis. We wanted to determine whether it distributes in any distinctive manner after mitotic nuclear envelope disassembly or is dispersed randomly throughout the cell. Our results reveal the golgi localization of HABP1 and demonstrate its complete dispersion throughout the cell during mitosis. This distinctive distribution pattern of HABP1 during mitosis resembles its ligand hyaluronan, suggesting that in concert with each other the two molecules play critical roles in this dynamic process.
journal_name
Cell Resjournal_title
Cell researchauthors
Sengupta A,Banerjee B,Tyagi RK,Datta Kdoi
10.1038/sj.cr.7290284keywords:
subject
Has Abstractpub_date
2005-03-01 00:00:00pages
183-6issue
3eissn
1001-0602issn
1748-7838journal_volume
15pub_type
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