Directional migration of leukocytes: their pathological roles in inflammation and strategies for development of anti-inflammatory therapies.

abstract：:CCAAT/enhancer binding protein alpha (C/EBPalpha) is a transcriptional regulatory factor that inhibits cell proliferation, and alternative translational initiation produces two polypeptides, C/EBPalphap30 and C/EBPalphap42. By expression profiling, it was revealed that C/EBPalphap30 specifically inhibited a unique set...

journal_title：Cell research

authors： Wang C,Chen X,Wang Y,Gong J,Hu G

更新日期：2007-04-01 00:00:00

abstract：:Neural crest (NC) cells are a migratory cell population synonymous with vertebrate evolution. They generate a wide variety of cell and tissue types during embryonic and adult development including cartilage and bone, connective tissue, pigment and endocrine cells as well as neurons and glia amongst many others. Such i...

journal_title：Cell research

authors： Achilleos A,Trainor PA

更新日期：2012-02-01 00:00:00

abstract：:CD8 engagement with class I major histocompatibility antigens greatly enhances T-cell activation, but it is not clear how this is achieved. We address the question of whether or not the antibody-mediated ligation of CD8 alone induces transcriptional remodeling in a T-cell clone, using serial analysis of gene expressio...

journal_title：Cell research

authors： Abidi SH,Dong T,Vuong MT,Sreenu VB,Rowland-Jones SL,Evans EJ,Davis SJ

更新日期：2008-06-01 00:00:00

abstract：:Elimination of misfolded proteins of the endoplasmic reticulum (ER) requires their retrotranslocation from the ER to the cytosol via membrane-bound ubiquitin ligase complexes. Baldridge and Rapoport now reconstitute a key step of retrotranslocation, demonstrating a protein conduit gated by ubiquitination. ...

journal_title：Cell research

authors： Zhang T,Ye Y

更新日期：2016-10-01 00:00:00

abstract：:In 2006, the "wall came down" that limited the experimental conversion of differentiated cells into the pluripotent state. In a landmark report, Shinya Yamanaka's group described that a handful of transcription factors (Oct4, Sox2, Klf4 and c-Myc) can convert a differentiated cell back to pluripotency over the course ...

journal_title：Cell research

authors： Papp B,Plath K

更新日期：2011-03-01 00:00:00

abstract：:Amyloid-beta (Abeta) peptide, the primary constituent of senile plaques in Alzheimer's disease (AD), is generated by beta-secretase- and gamma-secretase-mediated sequential proteolysis of the amyloid precursor protein (APP). The aspartic protease, beta -site APP cleavage enzyme (BACE), has been identified as the main ...

journal_title：Cell research

authors： Zou L,Wang Z,Shen L,Bao GB,Wang T,Kang JH,Pei G

更新日期：2007-05-01 00:00:00

abstract：:In vivo genome editing represents a powerful strategy for both understanding basic biology and treating inherited diseases. However, it remains a challenge to develop universal and efficient in vivo genome-editing tools for tissues that comprise diverse cell types in either a dividing or non-dividing state. Here, we d...

journal_title：Cell research

authors： Suzuki K,Yamamoto M,Hernandez-Benitez R,Li Z,Wei C,Soligalla RD,Aizawa E,Hatanaka F,Kurita M,Reddy P,Ocampo A,Hishida T,Sakurai M,Nemeth AN,Nuñez Delicado E,Campistol JM,Magistretti P,Guillen P,Rodriguez Esteban C,G

更新日期：2019-10-01 00:00:00

abstract：:Exosome-mediated intercellular communication has become an emerging field of human health and diseases. A recent study published by Cell Research reports that in zebrafish neurons can remotely regulate blood-brain barrier integrity by delivering miR-132 through secretion of exosomes. ...

journal_title：Cell research

authors： Zhao Z,Zlokovic BV

更新日期：2017-07-01 00:00:00

abstract：:RIG-I belongs to a type of intracellular pattern recognition receptors involved in the recognition of viral RNA by the innate immune system. A report by Peisley et al. published in Nature provides the crystal structure of human RIG-I revealing a tetrameric architecture of the RIG-I 2-CARD domain bound by three K63-lin...

journal_title：Cell research

authors： Zhu S,Jackson R,Flavell RA

更新日期：2014-06-01 00:00:00

abstract：:Various systems by using electric pulse, calcium, or polyethylene glycol have been developed in the past decade for the in vitro fusion of plant gametes. These in vitro systems provide a new way to study the fertilization mechanisms of plants. In this study, we developed a bovine serum albumin (BSA)-mediated fusion sy...

journal_title：Cell research

authors： Peng XB,Sun MX,Yang HY

更新日期：2005-09-01 00:00:00

abstract：:Fishes, the biggest and most diverse community in vertebrates are good experimental models for studies of cell and developmental biology by many favorable characteristics. Nuclear transplantation in fish has been thoroughly studied in China since 1960s. Fish nuclei of embryonic cells from different genera were transpl...

journal_title：Cell research

authors： Zhu ZY,Sun YH

更新日期：2000-03-01 00:00:00

abstract：:While N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic mRNA, is linked to cell differentiation and tissue development, the biological significance of m6A modification in mammalian glial development remains unknown. Here, we identify a novel m6A reader, Prrc2a (Proline rich coiled-coil 2 ...

journal_title：Cell research

authors： Wu R,Li A,Sun B,Sun JG,Zhang J,Zhang T,Chen Y,Xiao Y,Gao Y,Zhang Q,Ma J,Yang X,Liao Y,Lai WY,Qi X,Wang S,Shu Y,Wang HL,Wang F,Yang YG,Yuan Z

更新日期：2019-01-01 00:00:00

abstract：:CRISPR-Cas9 and CRISPR-Cpf1 systems have been successfully harnessed for genome editing. In the CRISPR-Cas9 system, the preordered A-form RNA seed sequence and preformed protein PAM-interacting cleft are essential for Cas9 to form a DNA recognition-competent structure. Whether the CRISPR-Cpf1 system employs a similar ...

journal_title：Cell research

authors： Gao P,Yang H,Rajashankar KR,Huang Z,Patel DJ

更新日期：2016-08-01 00:00:00

abstract：:The neurodegenerative polyglutamine diseases are caused by an expansion of unstable polyglutamine repeats in various disease proteins. Although these mutant proteins are expressed ubiquitously in neuronal and non-neuronal cells, they cause selective degeneration of specific neuronal populations. Recently, increasing e...

journal_title：Cell research

authors： Bradford JW,Li S,Li XJ

更新日期：2010-04-01 00:00:00

abstract：:Two distinct nuclear factor κB (NFκB) signaling pathways have been described; the canonical pathway that mediates inflammatory responses, and the non-canonical pathway that is involved in immune cell differentiation and maturation and secondary lymphoid organogenesis. The former is dependent on the IκB kinase adaptor ...

journal_title：Cell research

authors： Shih VF,Tsui R,Caldwell A,Hoffmann A

更新日期：2011-01-01 00:00:00

abstract：:Neural stem cells (NSCs) constitute the cellular basis for embryonic brain development and neurogenesis. The process is regulated by NSC niche including neighbor cells such as vascular and glial cells. Since both vascular and glial cells secrete vascular endothelial growth factor (VEGF) and basic fibroblast growth fac...

journal_title：Cell research

authors： Xiao Z,Kong Y,Yang S,Li M,Wen J,Li L

更新日期：2007-01-01 00:00:00

abstract：:Leaf morphogenesis requires the establishment of adaxial-abaxial polarity after primordium initiation from the shoot apical meristem (SAM). Several families of transcription factors are known to play critical roles in promoting adaxial or abaxial leaf fate. Recently, post-transcriptional gene silencing pathways have b...

journal_title：Cell research

authors： Xu L,Yang L,Huang H

更新日期：2007-06-01 00:00:00

abstract：:UV-B (280-315 nm) is an integral part of solar radiation and can act either as a stress inducer or as a developmental signal. In recent years, increasing attention has been paid to the low-fluence UV-B-induced photomorphogenic response and several key players in this response have been identified, which include UVR8 (...

journal_title：Cell research

authors： Jiang L,Wang Y,Li QF,Björn LO,He JX,Li SS

更新日期：2012-06-01 00:00:00

abstract：:In searching for differentially expressed genes in human uterine leiomyomas (ULs), suppression subtractive hybridization was used to construct an UL up-regulated library, which turned out to represent 88 genes. After two rounds of screening by reverse Northern analysis, twenty genes were proved to be up-regulated, inc...

journal_title：Cell research

authors： Li B,Zhang YL

更新日期：2002-09-01 00:00:00

abstract：:The impairment of mitochondrial bioenergetics, often coupled with exaggerated reactive oxygen species (ROS) production, is a fundamental disease mechanism in organs with a high demand for energy, including the heart. Building a more robust and safer cellular powerhouse holds the promise for protecting these organs in ...

journal_title：Cell research

authors： Hou T,Zhang R,Jian C,Ding W,Wang Y,Ling S,Ma Q,Hu X,Cheng H,Wang X

更新日期：2019-09-01 00:00:00

abstract：:Parthenogenetic embryonic stem (pES) cells provide a valuable in vitro model system for studying the molecular mechanisms that underlie genomic imprinting. However, the pluripotency of pES cells and the expression profiles of paternally expressed imprinted genes have not been fully explored. In this study, three mouse...

journal_title：Cell research

authors： Jiang H,Sun B,Wang W,Zhang Z,Gao F,Shi G,Cui B,Kong X,He Z,Ding X,Kuang Y,Fei J,Sun YJ,Feng Y,Jin Y

更新日期：2007-09-01 00:00:00

abstract：:Wnt/β-catenin signaling is essential for the initiation of dorsal-ventral patterning during vertebrate embryogenesis. Maternal β-catenin accumulates in dorsal marginal nuclei during cleavage stages, but its critical target genes essential for dorsalization are silent until mid-blastula transition (MBT). Here, we find ...

journal_title：Cell research

authors： Wei S,Dai M,Liu Z,Ma Y,Shang H,Cao Y,Wang Q

更新日期：2017-02-01 00:00:00

abstract：:A recent study led by Professor Rob Martienssen in Cell showed that 3'-tRNA-derived small RNAs can suppress long terminal repeat retrotransposon activity in mammalian cells by mechanisms independent of DNA-associated epigenetic marks, suggesting how the genome may defend itself from retrotransposon invasion during epi...

journal_title：Cell research

authors： Zhang Y,Shi J,Chen Q

更新日期：2017-11-01 00:00:00

abstract：:Human carcinomas are comprised of complex mixtures of tumor cells that are known to compete indirectly for nutrients and growth factors. Whether tumor cells could also compete directly, for example by elimination of rivals, is not known. Here we show that human cells can directly compete by a mechanism of engulfment c...

journal_title：Cell research

authors： Sun Q,Luo T,Ren Y,Florey O,Shirasawa S,Sasazuki T,Robinson DN,Overholtzer M

更新日期：2014-11-01 00:00:00

abstract：:Stem cells, including both pluripotent stem cells and multipotent somatic stem cells, hold great potential for interrogating the mechanisms of tissue development, homeostasis and pathology, and for treating numerous devastating diseases. Establishment of in vitro platforms to faithfully maintain and precisely manipula...

journal_title：Cell research

authors： Li W,Jiang K,Wei W,Shi Y,Ding S

更新日期：2013-01-01 00:00:00

abstract：:The pituitary adenylate cyclase-activating polypeptide type I receptor (PAC1R) belongs to the secretin receptor family and is widely distributed in the central neural system and peripheral organs. Abnormal activation of the receptor mediates trigeminovascular activation and sensitization, which is highly related to mi...

journal_title：Cell research

authors： Wang J,Song X,Zhang D,Chen X,Li X,Sun Y,Li C,Song Y,Ding Y,Ren R,Harrington EH,Hu LA,Zhong W,Xu C,Huang X,Wang HW,Ma Y

更新日期：2020-05-01 00:00:00

abstract：:Atrial natriuretic peptide (ANP) is an important component of the natriuretic peptide system. A great role in many regulatory systems is played by mast cells. Meanwhile involvement of these cells in ANP activity is poorly studied. In this work, we have shown the presence of ANP in rat peritoneal mast cells. Pure fract...

journal_title：Cell research

authors： Martynova MG,Bystrova OA,Moiseeva OM,Evdonin AL,Kondratov KA,Medvedeva ND

更新日期：2005-10-01 00:00:00

abstract：:Morphologically, caveolae and lipid rafts are two different membrane structures. They are often reported to share similar lipid and protein compositions, and are considered to be two subtypes of membrane lipid microdomains. By modifying sucrose density gradient flotation centrifugation, which is used to isolate lipid ...

journal_title：Cell research

authors： Yao Y,Hong S,Zhou H,Yuan T,Zeng R,Liao K

更新日期：2009-04-01 00:00:00

abstract：:Mouse sp56 is considered as one of the candidates for mouse zona pellucida 3 (mZP3) receptor. Up to date, its homologue has only been cloned from guinea pig, namely AM67. Based on the cDNA sequence of mouse sp56, we designed a pair of primer to amplify its homologue from rat testis cDNA. Using RT-PCR, two fragments of...

journal_title：Cell research

authors： He XB,Yan YC,Li YP,Koide SS

更新日期：2003-04-01 00:00:00

abstract：:Dysregulation of beta-site APP-cleaving enzyme (BACE) and/or gamma-secretase leads to anomalous production of amyloid-beta peptide (Abeta) and contributes to the etiology of Alzheimer's disease (AD). Since these secretases mediate proteolytic processing of numerous proteins, little success has been achieved to treat A...

journal_title：Cell research

authors： Teng L,Zhao J,Wang F,Ma L,Pei G

更新日期：2010-02-01 00:00:00