Competition between human cells by entosis.

Abstract:

:Human carcinomas are comprised of complex mixtures of tumor cells that are known to compete indirectly for nutrients and growth factors. Whether tumor cells could also compete directly, for example by elimination of rivals, is not known. Here we show that human cells can directly compete by a mechanism of engulfment called entosis. By entosis, cells are engulfed, or cannibalized while alive, and subsequently undergo cell death. We find that the identity of engulfing ("winner") and engulfed ("loser") cells is dictated by mechanical deformability controlled by RhoA and actomyosin, where tumor cells with high deformability preferentially engulf and outcompete neighboring cells with low deformability in heterogeneous populations. We further find that activated Kras and Rac signaling impart winner status to cells by downregulating contractile myosin, allowing for the internalization of neighboring cells that eventually undergo cell death. Finally, we compute the energy landscape of cell-in-cell formation, demonstrating that a mechanical differential between winner and loser cells is required for entosis to proceed. These data define a mechanism of competition in mammalian cells that occurs in human tumors.

journal_name

Cell Res

journal_title

Cell research

authors

Sun Q,Luo T,Ren Y,Florey O,Shirasawa S,Sasazuki T,Robinson DN,Overholtzer M

doi

10.1038/cr.2014.138

subject

Has Abstract

pub_date

2014-11-01 00:00:00

pages

1299-310

issue

11

eissn

1001-0602

issn

1748-7838

pii

cr2014138

journal_volume

24

pub_type

杂志文章
  • Arabidopsis STO/BBX24 negatively regulates UV-B signaling by interacting with COP1 and repressing HY5 transcriptional activity.

    abstract::UV-B (280-315 nm) is an integral part of solar radiation and can act either as a stress inducer or as a developmental signal. In recent years, increasing attention has been paid to the low-fluence UV-B-induced photomorphogenic response and several key players in this response have been identified, which include UVR8 (...

    journal_title:Cell research

    pub_type: 杂志文章

    doi:10.1038/cr.2012.34

    authors: Jiang L,Wang Y,Li QF,Björn LO,He JX,Li SS

    更新日期:2012-06-01 00:00:00

  • Visualization of bHLH transcription factor interactions in living mammalian cell nuclei and developing chicken neural tube by FRET.

    abstract::Members of the basic helix-loop-helix (bHLH) gene family play important roles in vertebrate neurogenesis. In this study, confocal microscopy-based fluorescence resonance energy transfer (FRET) is used to monitor bHLH protein-protein interactions under various physiological conditions. Tissue-specific bHLH activators, ...

    journal_title:Cell research

    pub_type: 杂志文章

    doi:10.1038/sj.cr.7310076

    authors: Wang C,Bian W,Xia C,Zhang T,Guillemot F,Jing N

    更新日期:2006-06-01 00:00:00

  • Traffic control at the "Gut-GALT crossroads".

    abstract::In mice treated with antibiotics to deplete commensal microbiota, there is a significant overhaul of host cellular disposition and function with CX3CR1+ mononuclear phagocytic cells carrying pathogenic and non-pathogenic administered bacteria to the (messenteric lymph node) MLN, resulting in T cell stimulation and IgA...

    journal_title:Cell research

    pub_type: 杂志文章

    doi:10.1038/cr.2013.41

    authors: Dasgupta S,Kasper DL

    更新日期:2013-05-01 00:00:00

  • Toward targeting inflammasomes: insights into their regulation and activation.

    abstract::Inflammasomes are multi-component signaling complexes critical to the initiation of pyroptotic cell death in response to invading pathogens and cellular damage. A number of innate immune receptors have been reported to serve as inflammasome sensors. Activation of these sensors leads to the proteolytic activation of ca...

    journal_title:Cell research

    pub_type: 杂志文章

    doi:10.1038/s41422-020-0295-8

    authors: Christgen S,Place DE,Kanneganti TD

    更新日期:2020-04-01 00:00:00

  • Knockdown of CD146 reduces the migration and proliferation of human endothelial cells.

    abstract::Our previous study has demonstrated that CD146 molecule is a biomarker on vascular endothelium, which is involved in angiogenesis and tumor growth. However the mechanism behind is not clear. Here we have for the first time developed a novel CD146 blockade system using CD146 siRNA to study its function on endothelial c...

    journal_title:Cell research

    pub_type: 杂志文章

    doi:10.1038/sj.cr.7310039

    authors: Kang Y,Wang F,Feng J,Yang D,Yang X,Yan X

    更新日期:2006-03-01 00:00:00

  • NDUFAB1 confers cardio-protection by enhancing mitochondrial bioenergetics through coordination of respiratory complex and supercomplex assembly.

    abstract::The impairment of mitochondrial bioenergetics, often coupled with exaggerated reactive oxygen species (ROS) production, is a fundamental disease mechanism in organs with a high demand for energy, including the heart. Building a more robust and safer cellular powerhouse holds the promise for protecting these organs in ...

    journal_title:Cell research

    pub_type: 杂志文章

    doi:10.1038/s41422-019-0208-x

    authors: Hou T,Zhang R,Jian C,Ding W,Wang Y,Ling S,Ma Q,Hu X,Cheng H,Wang X

    更新日期:2019-09-01 00:00:00

  • A novel in vitro system for gamete fusion in maize.

    abstract::Various systems by using electric pulse, calcium, or polyethylene glycol have been developed in the past decade for the in vitro fusion of plant gametes. These in vitro systems provide a new way to study the fertilization mechanisms of plants. In this study, we developed a bovine serum albumin (BSA)-mediated fusion sy...

    journal_title:Cell research

    pub_type: 杂志文章

    doi:10.1038/sj.cr.7290343

    authors: Peng XB,Sun MX,Yang HY

    更新日期:2005-09-01 00:00:00

  • In vivo reprogramming for heart disease.

    abstract::The term "lineage reprogramming" is typically used to describe the conversion of one differentiated somatic cell type into another without transit through a pluripotent intermediate. Two recent reports in Nature demonstrate that such a conversion can be achieved in the heart in situ, and suggest a novel, regenerative ...

    journal_title:Cell research

    pub_type: 杂志文章

    doi:10.1038/cr.2012.101

    authors: Xu H,Yi BA,Chien KR

    更新日期:2012-11-01 00:00:00

  • Mex3B: a coreceptor to present dsRNA to TLR3.

    abstract::Toll-Like Receptors (TLRs) play critical roles in the early innate immune response to invading pathogens by sensing microorganisms; a number of accessory molecules have been shown to assist microbial recognition by TLRs. In a recent paper in Cell Research, Yang et al. demonstrate that Mex3B is associated with TLR3 in ...

    journal_title:Cell research

    pub_type: 评论,杂志文章

    doi:10.1038/cr.2016.29

    authors: Zhu S,Wang G,Lei X,Flavell RA

    更新日期:2016-04-01 00:00:00

  • Methyl-CpG binding proteins in the nervous system.

    abstract::Classical methyl-CpG binding proteins contain the conserved DNA binding motif methyl-cytosine binding domain (MBD), which preferentially binds to methylated CpG dinucleotides. These proteins serve as transcriptional repressors, mediating gene silencing via DNA cytosine methylation. Mutations in methyl-CpG binding prot...

    journal_title:Cell research

    pub_type: 杂志文章,评审

    doi:10.1038/sj.cr.7290294

    authors: Fan G,Hutnick L

    更新日期:2005-04-01 00:00:00

  • Releasing the break on X chromosome inactivation: Rnf12/RLIM targets REX1 for degradation.

    abstract::One of the two X chromosomes in cells of female mammals is transcriptionally silenced in a process known as X chromosome inactivation (XCI). Initiation of XCI is regulated by the ubiquitin ligase Rnf12/RLIM, but the mechanisms by which Rnf12/RLIM mediates this process has been a mystery. A recent study by Gontan et al...

    journal_title:Cell research

    pub_type: 杂志文章

    doi:10.1038/cr.2012.98

    authors: Bach I

    更新日期:2012-11-01 00:00:00

  • Molecular mechanisms of "off-on switch" of activities of human IDH1 by tumor-associated mutation R132H.

    abstract::Human cytosolic NADP-IDH (IDH1) has recently been found to be involved in tumorigenesis. Notably, the tumor-derived IDH1 mutations identified so far mainly occur at Arg132, and mutation R132H is the most prevalent one. This mutation impairs the oxidative IDH activity of the enzyme, but renders a new reduction function...

    journal_title:Cell research

    pub_type: 杂志文章

    doi:10.1038/cr.2010.145

    authors: Yang B,Zhong C,Peng Y,Lai Z,Ding J

    更新日期:2010-11-01 00:00:00

  • Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism.

    abstract::The pituitary adenylate cyclase-activating polypeptide type I receptor (PAC1R) belongs to the secretin receptor family and is widely distributed in the central neural system and peripheral organs. Abnormal activation of the receptor mediates trigeminovascular activation and sensitization, which is highly related to mi...

    journal_title:Cell research

    pub_type: 杂志文章

    doi:10.1038/s41422-020-0280-2

    authors: Wang J,Song X,Zhang D,Chen X,Li X,Sun Y,Li C,Song Y,Ding Y,Ren R,Harrington EH,Hu LA,Zhong W,Xu C,Huang X,Wang HW,Ma Y

    更新日期:2020-05-01 00:00:00

  • Circular RNAs: Coding or noncoding?

    abstract::Circular RNAs (circRNAs) were only recently discovered as a new class of noncoding RNAs, functionally still largely uncharacterized. Three publications that appeared concurrently in Cell Research and Molecular Cell provide initial evidence for certain endogenous circRNAs coding for proteins. ...

    journal_title:Cell research

    pub_type: 杂志文章

    doi:10.1038/cr.2017.70

    authors: Schneider T,Bindereif A

    更新日期:2017-06-01 00:00:00

  • VEGFR-3 ligand-binding and kinase activity are required for lymphangiogenesis but not for angiogenesis.

    abstract::Although VEGFR-3 deficiency disrupts blood vascular development during early embryogenesis, the underlying mechanism was not clear. To characterize its function in angiogenesis and lymphangiogenesis, we employed two genetically modified mouse models in this study, targeting the coding region for the ligand-binding dom...

    journal_title:Cell research

    pub_type: 杂志文章

    doi:10.1038/cr.2010.116

    authors: Zhang L,Zhou F,Han W,Shen B,Luo J,Shibuya M,He Y

    更新日期:2010-12-01 00:00:00

  • A novel selective autophagy receptor, CCDC50, delivers K63 polyubiquitination-activated RIG-I/MDA5 for degradation during viral infection.

    abstract::Autophagy is a conserved process that delivers cytosolic substances to the lysosome for degradation, but its direct role in the regulation of antiviral innate immunity remains poorly understood. Here, through high-throughput screening, we discovered that CCDC50 functions as a previously unknown autophagy receptor that...

    journal_title:Cell research

    pub_type: 杂志文章

    doi:10.1038/s41422-020-0362-1

    authors: Hou P,Yang K,Jia P,Liu L,Lin Y,Li Z,Li J,Chen S,Guo S,Pan J,Wu J,Peng H,Zeng W,Li C,Liu Y,Guo D

    更新日期:2021-01-01 00:00:00

  • MRG-1 is required for genomic integrity in Caenorhabditis elegans germ cells.

    abstract::During meiotic cell division, proper chromosome synapsis and accurate repair of DNA double strand breaks (DSBs) are required to maintain genomic integrity, loss of which leads to apoptosis or meiotic defects. The mechanisms underlying meiotic chromosome synapsis, DSB repair and apoptosis are not fully understood. Here...

    journal_title:Cell research

    pub_type: 杂志文章

    doi:10.1038/cr.2012.2

    authors: Xu J,Sun X,Jing Y,Wang M,Liu K,Jian Y,Yang M,Cheng Z,Yang C

    更新日期:2012-05-01 00:00:00

  • Chemical approaches to studying stem cell biology.

    abstract::Stem cells, including both pluripotent stem cells and multipotent somatic stem cells, hold great potential for interrogating the mechanisms of tissue development, homeostasis and pathology, and for treating numerous devastating diseases. Establishment of in vitro platforms to faithfully maintain and precisely manipula...

    journal_title:Cell research

    pub_type: 杂志文章,评审

    doi:10.1038/cr.2012.182

    authors: Li W,Jiang K,Wei W,Shi Y,Ding S

    更新日期:2013-01-01 00:00:00

  • Identification of up-regulated genes in human uterine leiomyoma by suppression subtractive hybridization.

    abstract::In searching for differentially expressed genes in human uterine leiomyomas (ULs), suppression subtractive hybridization was used to construct an UL up-regulated library, which turned out to represent 88 genes. After two rounds of screening by reverse Northern analysis, twenty genes were proved to be up-regulated, inc...

    journal_title:Cell research

    pub_type: 杂志文章

    doi:10.1038/sj.cr.7290127

    authors: Li B,Zhang YL

    更新日期:2002-09-01 00:00:00

  • IFNβ/TNFα synergism induces a non-canonical STAT2/IRF9-dependent pathway triggering a novel DUOX2 NADPH oxidase-mediated airway antiviral response.

    abstract::Airway epithelial cells are key initial innate immune responders in the fight against respiratory viruses, primarily via the secretion of antiviral and proinflammatory cytokines that act in an autocrine/paracrine fashion to trigger the establishment of an antiviral state. It is currently thought that the early antivir...

    journal_title:Cell research

    pub_type: 杂志文章

    doi:10.1038/cr.2013.47

    authors: Fink K,Martin L,Mukawera E,Chartier S,De Deken X,Brochiero E,Miot F,Grandvaux N

    更新日期:2013-05-01 00:00:00

  • The culture and establishment of embryonic germ (EG) cell lines from Chinese mini swine.

    abstract::As a part of a basic research project on Xeno-transplantion, we have been engaged in the derivation of embryonic stem cell lines from Chinese mini swine. Here, we reported for the first time the establishment of two porcine EG cell lines (BPEG1 and BPEG2) from primordial germ cells of genital ridges of a 28 and a 27 d...

    journal_title:Cell research

    pub_type: 杂志文章

    doi:10.1038/sj.cr.7290164

    authors: Tsung HC,Du ZW,Rui R,Li XL,Bao LP,Wu J,Bao SM,Yao Z

    更新日期:2003-06-01 00:00:00

  • The presence of ANP in rat peritoneal mast cells.

    abstract::Atrial natriuretic peptide (ANP) is an important component of the natriuretic peptide system. A great role in many regulatory systems is played by mast cells. Meanwhile involvement of these cells in ANP activity is poorly studied. In this work, we have shown the presence of ANP in rat peritoneal mast cells. Pure fract...

    journal_title:Cell research

    pub_type: 杂志文章

    doi:10.1038/sj.cr.7290350

    authors: Martynova MG,Bystrova OA,Moiseeva OM,Evdonin AL,Kondratov KA,Medvedeva ND

    更新日期:2005-10-01 00:00:00

  • Skeletal muscle mitochondrial remodeling in exercise and diseases.

    abstract::Skeletal muscle fitness and plasticity is an important determinant of human health and disease. Mitochondria are essential for maintaining skeletal muscle energy homeostasis by adaptive re-programming to meet the demands imposed by a myriad of physiologic or pathophysiological stresses. Skeletal muscle mitochondrial d...

    journal_title:Cell research

    pub_type: 杂志文章,评审

    doi:10.1038/s41422-018-0078-7

    authors: Gan Z,Fu T,Kelly DP,Vega RB

    更新日期:2018-10-01 00:00:00

  • Myosin binding protein C: structural abnormalities in familial hypertrophic cardiomyopathy.

    abstract::The muscle protein myosin binding protein C (MyBPC) is a large multi-domain protein whose role in the sarcomere is complex and not yet fully understood. Mutations in MyBPC are strongly associated with the heart disease familial hypertrophic cardiomyopathy (FHC) and these experiments of nature have provided some insigh...

    journal_title:Cell research

    pub_type: 杂志文章,评审

    doi:10.1038/sj.cr.7290208

    authors: Oakley CE,Hambly BD,Curmi PM,Brown LJ

    更新日期:2004-04-01 00:00:00

  • Embryonic and genetic manipulation in fish.

    abstract::Fishes, the biggest and most diverse community in vertebrates are good experimental models for studies of cell and developmental biology by many favorable characteristics. Nuclear transplantation in fish has been thoroughly studied in China since 1960s. Fish nuclei of embryonic cells from different genera were transpl...

    journal_title:Cell research

    pub_type: 杂志文章,评审

    doi:10.1038/sj.cr.7290032

    authors: Zhu ZY,Sun YH

    更新日期:2000-03-01 00:00:00

  • Mouse cloning and somatic cell reprogramming using electrofused blastomeres.

    abstract::Mouse cloning from fertilized eggs can assist development of approaches for the production of "genetically tailored" human embryonic stem (ES) cell lines that are not constrained by the limitations of oocyte availability. However, to date only zygotes have been successfully used as recipients of nuclei from terminally...

    journal_title:Cell research

    pub_type: 杂志文章

    doi:10.1038/cr.2010.180

    authors: Riaz A,Zhao X,Dai X,Li W,Liu L,Wan H,Yu Y,Wang L,Zhou Q

    更新日期:2011-05-01 00:00:00

  • The lock-washer: a reconciliation of the RIG-I activation models.

    abstract::RIG-I belongs to a type of intracellular pattern recognition receptors involved in the recognition of viral RNA by the innate immune system. A report by Peisley et al. published in Nature provides the crystal structure of human RIG-I revealing a tetrameric architecture of the RIG-I 2-CARD domain bound by three K63-lin...

    journal_title:Cell research

    pub_type: 评论,杂志文章

    doi:10.1038/cr.2014.58

    authors: Zhu S,Jackson R,Flavell RA

    更新日期:2014-06-01 00:00:00

  • Protein C receptor is a therapeutic stem cell target in a distinct group of breast cancers.

    abstract::Breast cancer is a heterogeneous disease. In particular, triple-negative breast cancer (TNBC) comprises various molecular subgroups with unclear identities and currently has few targeted treatment options. Our previous study identified protein C receptor (Procr) as a surface marker on mammary stem cells (MaSCs) locate...

    journal_title:Cell research

    pub_type: 杂志文章

    doi:10.1038/s41422-019-0225-9

    authors: Wang D,Hu X,Liu C,Jia Y,Bai Y,Cai C,Wang J,Bai L,Yang R,Lin C,Liu YR,Li S,Qiao F,Yao L,Chen L,Ge G,Jiang H,Li D,Li L,Chen J,Shao ZM,Zeng YA

    更新日期:2019-10-01 00:00:00

  • Where long noncoding RNAs meet DNA methylation.

    abstract::DNA methylation is a fundamental epigenetic mechanism governing regulation of gene expression during mammalian development. A recent study published in Nature shows a novel long noncoding RNA (lncRNA) arising from the CEBPA gene locus (termed ecCEBPA) that is critical for regulation of DNA methylation at this site thr...

    journal_title:Cell research

    pub_type: 杂志文章

    doi:10.1038/cr.2014.13

    authors: Lai F,Shiekhattar R

    更新日期:2014-03-01 00:00:00

  • Dapper1 promotes autophagy by enhancing the Beclin1-Vps34-Atg14L complex formation.

    abstract::Autophagy is an intracellular degradation process to clear up aggregated proteins or aged and damaged organelles. The Beclin1-Vps34-Atg14L complex is essential for autophagosome formation. However, how the complex formation is regulated is unclear. Here, we show that Dapper1 (Dpr1) acts as a critical regulator of the ...

    journal_title:Cell research

    pub_type: 杂志文章

    doi:10.1038/cr.2014.84

    authors: Ma B,Cao W,Li W,Gao C,Qi Z,Zhao Y,Du J,Xue H,Peng J,Wen J,Chen H,Ning Y,Huang L,Zhang H,Gao X,Yu L,Chen YG

    更新日期:2014-08-01 00:00:00