Cloning and molecular characterization of a novel lectin gene from Pinellia ternata.

abstract：:The formation of long-term memory is critical for learning ability and social behaviors of humans and animals, yet its underlying mechanisms are largely unknown. We found that the efficacy of hippocampus-dependent memory consolidation is regulated by METTL3, an RNA N6-methyladenosine (m6A) methyltransferase, through p...

journal_title：Cell research

authors： Zhang Z,Wang M,Xie D,Huang Z,Zhang L,Yang Y,Ma D,Li W,Zhou Q,Yang YG,Wang XJ

更新日期：2018-11-01 00:00:00

abstract：:Stem cells, including both pluripotent stem cells and multipotent somatic stem cells, hold great potential for interrogating the mechanisms of tissue development, homeostasis and pathology, and for treating numerous devastating diseases. Establishment of in vitro platforms to faithfully maintain and precisely manipula...

journal_title：Cell research

authors： Li W,Jiang K,Wei W,Shi Y,Ding S

更新日期：2013-01-01 00:00:00

abstract：:Long-range chromatin interactions between enhancers and promoters are essential for transcription of many developmentally controlled genes in mammals and other metazoans. Currently, the exact mechanisms that connect distal enhancers to their specific target promoters remain to be fully elucidated. Here, we show that t...

journal_title：Cell research

authors： Yan J,Chen SA,Local A,Liu T,Qiu Y,Dorighi KM,Preissl S,Rivera CM,Wang C,Ye Z,Ge K,Hu M,Wysocka J,Ren B

更新日期：2018-02-01 00:00:00

abstract：:All known subtypes of influenza A viruses are maintained in wild waterfowl, the natural reservoir of these viruses. Influenza A viruses are isolated from a variety of animal species with varying morbidity and mortality rates. More importantly, influenza A viruses cause respiratory disease in humans with potentially fa...

journal_title：Cell research

authors： Neumann G,Chen H,Gao GF,Shu Y,Kawaoka Y

更新日期：2010-01-01 00:00:00

abstract：:High-density lipoproteins (HDLs) have been well established to protect against the development of atherosclerotic cardiovascular disease. It has become apparent that in addition to the promotion of reverse cholesterol transport, HDLs possess a number of additional functional properties that may contribute to their ben...

journal_title：Cell research

authors： Cutri BA,Hime NJ,Nicholls SJ

更新日期：2006-10-01 00:00:00

abstract：:CD8 engagement with class I major histocompatibility antigens greatly enhances T-cell activation, but it is not clear how this is achieved. We address the question of whether or not the antibody-mediated ligation of CD8 alone induces transcriptional remodeling in a T-cell clone, using serial analysis of gene expressio...

journal_title：Cell research

authors： Abidi SH,Dong T,Vuong MT,Sreenu VB,Rowland-Jones SL,Evans EJ,Davis SJ

更新日期：2008-06-01 00:00:00

abstract：:Critical epigenetic regulation of primate embryogenesis entails DNA methylome changes. Here we report genome-wide composition, patterning, and stage-specific dynamics of DNA methylation in pre-implantation rhesus monkey embryos as well as male and female gametes studied using an optimized tagmentation-based whole-geno...

journal_title：Cell research

authors： Gao F,Niu Y,Sun YE,Lu H,Chen Y,Li S,Kang Y,Luo Y,Si C,Yu J,Li C,Sun N,Si W,Wang H,Ji W,Tan T

更新日期：2017-04-01 00:00:00

abstract：:Fishes, the biggest and most diverse community in vertebrates are good experimental models for studies of cell and developmental biology by many favorable characteristics. Nuclear transplantation in fish has been thoroughly studied in China since 1960s. Fish nuclei of embryonic cells from different genera were transpl...

journal_title：Cell research

authors： Zhu ZY,Sun YH

更新日期：2000-03-01 00:00:00

abstract：:Pluripotent stem cells (PSCs) harbor constitutive DNA replication stress during their rapid proliferation and the consequent genome instability hampers their applications in regenerative medicine. It is therefore important to understand the regulatory mechanisms of replication stress response in PSCs. Here, we report ...

journal_title：Cell research

authors： Zhao B,Zhang W,Cun Y,Li J,Liu Y,Gao J,Zhu H,Zhou H,Zhang R,Zheng P

更新日期：2018-01-01 00:00:00

abstract：:International non-governmental organizations were among the first international actors that responded to the emergence of AIDS crisis in China. Since 1994, the number of international non-governmental organizations and charitable foundations working in AIDS related issue areas in China has grown steadily and substanti...

journal_title：Cell research

authors： Wu FS

更新日期：2005-11-01 00:00:00

abstract：:The highly conserved polycomb group (PcG) proteins maintain heritable transcription repression of the genes essential for development from fly to mammals. However, sporadic reports imply a potential role of PcGs in positive regulation of gene transcription, although systematic investigation of such function and the un...

journal_title：Cell research

authors： Lv X,Han Z,Chen H,Yang B,Yang X,Xia Y,Pan C,Fu L,Zhang S,Han H,Wu M,Zhou Z,Zhang L,Li L,Wei G,Zhao Y

更新日期：2016-05-01 00:00:00

abstract：:The completion of genome sequences and subsequent high-throughput mapping of molecular networks have allowed us to study biology from the network perspective. Experimental, statistical and mathematical modeling approaches have been employed to study the structure, function and dynamics of molecular networks, and begin...

journal_title：Cell research

authors： Han JD

更新日期：2008-02-01 00:00:00

abstract：:Intermittent fasting (IF) has been shown to promote metabolic health in several organisms. Two recent papers show that IF induces white adipose tissue beiging and increases thermogenesis, which improves metabolic health in mice. ...

journal_title：Cell research

authors： Kivelä R,Alitalo K

更新日期：2017-11-01 00:00:00

abstract：:CCAAT/enhancer binding protein alpha (C/EBPalpha) is a transcriptional regulatory factor that inhibits cell proliferation, and alternative translational initiation produces two polypeptides, C/EBPalphap30 and C/EBPalphap42. By expression profiling, it was revealed that C/EBPalphap30 specifically inhibited a unique set...

journal_title：Cell research

authors： Wang C,Chen X,Wang Y,Gong J,Hu G

更新日期：2007-04-01 00:00:00

abstract：:The term "lineage reprogramming" is typically used to describe the conversion of one differentiated somatic cell type into another without transit through a pluripotent intermediate. Two recent reports in Nature demonstrate that such a conversion can be achieved in the heart in situ, and suggest a novel, regenerative ...

journal_title：Cell research

authors： Xu H,Yi BA,Chien KR

更新日期：2012-11-01 00:00:00

abstract：:It is well documented that g-aminobutyric acid (GABA) system existed in reproductive organs. Recent researches showed that GABAA and GABAB receptors were present in testis and sperm, and might mediate the acrosome reaction induced by GABA and progesterone. GABA transporter I (GAT1) also existed in testis and sperm, bu...

journal_title：Cell research

authors： Hu JH,Zhang JF,Ma YH,Jiang J,Yang N,Li XB,Yu Chi ZG,Fei J,Guo LH

更新日期：2004-02-01 00:00:00

abstract：:Although VEGFR-3 deficiency disrupts blood vascular development during early embryogenesis, the underlying mechanism was not clear. To characterize its function in angiogenesis and lymphangiogenesis, we employed two genetically modified mouse models in this study, targeting the coding region for the ligand-binding dom...

journal_title：Cell research

authors： Zhang L,Zhou F,Han W,Shen B,Luo J,Shibuya M,He Y

更新日期：2010-12-01 00:00:00

abstract：:The study of pathophysiological mechanisms in human liver disease has been constrained by the inability to expand primary hepatocytes in vitro while maintaining proliferative capacity and metabolic function. We and others have previously shown that mouse mature hepatocytes can be converted to liver progenitor-like cel...

journal_title：Cell research

authors： Fu GB,Huang WJ,Zeng M,Zhou X,Wu HP,Liu CC,Wu H,Weng J,Zhang HD,Cai YC,Ashton C,Ding M,Tang D,Zhang BH,Gao Y,Yu WF,Zhai B,He ZY,Wang HY,Yan HX

更新日期：2019-01-01 00:00:00

abstract：:Gonad development requires a coordinated soma-germline interaction that ensures renewal and differentiation of germline and somatic stem cells to ultimately produce mature gametes. The Drosophila tumour suppressor gene discs large (dlg) encodes a septate junction protein functioning during epithelial polarization, asy...

journal_title：Cell research

authors： Papagiannouli F,Mechler BM

更新日期：2009-10-01 00:00:00

abstract：:The TGF-beta superfamily members have important roles in controlling patterning and tissue formation in both invertebrates and vertebrates. Two types of signal transducers, receptors and Smads, mediate the signaling to regulate expression of their target genes. Despite of the relatively simple signal transduction path...

journal_title：Cell research

authors： Chen YG,Meng AM

更新日期：2004-12-01 00:00:00

abstract：:Recent studies on enzymes and reader proteins for histone crotonylation support a function of histone crotonylation in transcription. However, the enzyme(s) responsible for histone decrotonylation (HDCR) remains poorly defined. Moreover, it remains to be determined if histone crotonylation is physiologically significa...

journal_title：Cell research

authors： Wei W,Liu X,Chen J,Gao S,Lu L,Zhang H,Ding G,Wang Z,Chen Z,Shi T,Li J,Yu J,Wong J

更新日期：2017-07-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) play a significant role in regulating angiogenesis, the process of new blood vessel formation. Interstitial collagenase (MMP-1), 72 kDa gelatinase A/type IV collagenase (MMP-2), and 92 kDa gelatinase B/type IV collagenase (MMP-9) diss...

journal_title：Cell research

authors： Sang QX

更新日期：1998-09-01 00:00:00

abstract：:In 2006, the "wall came down" that limited the experimental conversion of differentiated cells into the pluripotent state. In a landmark report, Shinya Yamanaka's group described that a handful of transcription factors (Oct4, Sox2, Klf4 and c-Myc) can convert a differentiated cell back to pluripotency over the course ...

journal_title：Cell research

authors： Papp B,Plath K

更新日期：2011-03-01 00:00:00

abstract：:Atrial natriuretic peptide (ANP) is an important component of the natriuretic peptide system. A great role in many regulatory systems is played by mast cells. Meanwhile involvement of these cells in ANP activity is poorly studied. In this work, we have shown the presence of ANP in rat peritoneal mast cells. Pure fract...

journal_title：Cell research

authors： Martynova MG,Bystrova OA,Moiseeva OM,Evdonin AL,Kondratov KA,Medvedeva ND

更新日期：2005-10-01 00:00:00

abstract：:Human carcinomas are comprised of complex mixtures of tumor cells that are known to compete indirectly for nutrients and growth factors. Whether tumor cells could also compete directly, for example by elimination of rivals, is not known. Here we show that human cells can directly compete by a mechanism of engulfment c...

journal_title：Cell research

authors： Sun Q,Luo T,Ren Y,Florey O,Shirasawa S,Sasazuki T,Robinson DN,Overholtzer M

更新日期：2014-11-01 00:00:00

abstract：:Autophagy is an intracellular degradation process to clear up aggregated proteins or aged and damaged organelles. The Beclin1-Vps34-Atg14L complex is essential for autophagosome formation. However, how the complex formation is regulated is unclear. Here, we show that Dapper1 (Dpr1) acts as a critical regulator of the ...

journal_title：Cell research

authors： Ma B,Cao W,Li W,Gao C,Qi Z,Zhao Y,Du J,Xue H,Peng J,Wen J,Chen H,Ning Y,Huang L,Zhang H,Gao X,Yu L,Chen YG

更新日期：2014-08-01 00:00:00

abstract：:The cytotoxic T lymphocyte antigen-4 (CTLA-4)-blocking antibody ipilimumab induces immune-mediated long-term control of metastatic melanoma in a fraction of patients. Although ipilimumab undoubtedly exerts its therapeutic effects via immunostimulation, thus far clinically useful, immunologically relevant biomarkers th...

journal_title：Cell research

authors： Hannani D,Vétizou M,Enot D,Rusakiewicz S,Chaput N,Klatzmann D,Desbois M,Jacquelot N,Vimond N,Chouaib S,Mateus C,Allison JP,Ribas A,Wolchok JD,Yuan J,Wong P,Postow M,Mackiewicz A,Mackiewicz J,Schadendorff D,Jaeger

更新日期：2015-02-01 00:00:00

abstract：:The functional roles of memory B and T lymphocytes underlie the phenomenal success of prophylactic vaccinations, which have decreased morbidities and mortalities from infectious diseases globally over the last 50 years. However, it is becoming increasingly appreciated that memory cells are also capable of mediating th...

journal_title：Cell research

authors： DiSpirito JR,Shen H

更新日期：2010-01-01 00:00:00

abstract：:MicroRNA (miRNA) biogenesis is finely controlled by complex layers of post-transcriptional regulators, including RNA-binding proteins (RBPs). Here, we show that an RBP, QKI5, activates the processing of primary miR-124-1 (pri-124-1) during erythropoiesis. QKI5 recognizes a distal QKI response element and recruits Micr...

journal_title：Cell research

authors： Wang F,Song W,Zhao H,Ma Y,Li Y,Zhai D,Pi J,Si Y,Xu J,Dong L,Su R,Zhang M,Zhu Y,Ren X,Miao F,Liu W,Li F,Zhang J,He A,Shan G,Hui J,Wang L,Yu J

更新日期：2017-03-01 00:00:00

abstract：:Accumulating evidence indicates that the mesenchymal-epithelial transition (MET) and epithelial-mesenchymal transition (EMT) are basic mechanisms for cell fate conversion and may help us understand both physiologic and pathologic processes such as development and carcinogenesis. Here, we further suggest that mammalian...

journal_title：Cell research

authors： Zheng H,Hutchins AP,Pan G,Li Y,Pei D,Pei G

更新日期：2014-10-01 00:00:00