Abstract:
:The role of Ese-2, an Ets family transcription factor, in gene regulation is not known. In this study, the interaction between Ese-2 and cytokeratin 18 (K18) intron 1 was characterized in lung epithelial cells. Reporter gene assays showed Ese-2 was able to upregulate K18 intron 1 enhanced reporter gene expression by approximately 2-fold. We found that full length Ese-2 did not bind DNA strongly, therefore truncated versions of the protein, containing the ETS domain or Pointed domain, were created and tested in electrophoresis mobility shift assays. Multiple interactions between the ETS domain and putative DNA binding sites within K18 intron 1 were observed, which led to the determination of a possible Ese-2 DNA binding consensus sequence. These experiments suggest that Ese-2 could play a role in the regulation of K18 expression in lung epithelial cells.
journal_name
Cell Resjournal_title
Cell researchauthors
Yaniw D,Hu Jdoi
10.1038/sj.cr.7290310keywords:
subject
Has Abstractpub_date
2005-06-01 00:00:00pages
423-9issue
6eissn
1001-0602issn
1748-7838journal_volume
15pub_type
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