Abstract:
:In the present article, we report that DR4 or DR5 overexpression dramatically activates the release of the inflammatory cytokines IL-8, TNF-alpha, CCL20, MIP-2 and MIP-1beta in an NF-kappaB-dependent manner in 293T, MDA-MB-231 and HCT-116 cells. We showed that death receptor-mediated signals were extracellular domain-independent, whereas the effect of overexpression of the DR4 intracellular domain was much less potent. The TRADD-TRAF2-NIK-IKKalpha/beta signaling cascade, which plays an essential role in TNF-induced NF-kappaB activation, was found to be involved in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor-mediated signal transduction. The FADD-caspase signaling pathway, which has been reported to be mostly related to apoptosis, was identified as being essential for DR4 or DR5 overexpression-mediated NF-kappaB activation and cytokine secretion and crosstalks with the TRADD-TRAF2-NIK-IKKalpha/beta signaling cascade. Furthermore, a DR5 agonistic antibody (AD5-10) triggered the inflammatory cytokine release. These data, together with previous reports, provide strong evidence that TRAIL and TRAIL receptors play an important role in inflammation.
journal_name
Cell Resjournal_title
Cell researchauthors
Tang W,Wang W,Zhang Y,Liu S,Liu Y,Zheng Ddoi
10.1038/cr.2009.57subject
Has Abstractpub_date
2009-06-01 00:00:00pages
758-67issue
6eissn
1001-0602issn
1748-7838pii
cr200957journal_volume
19pub_type
杂志文章相关文献
CELL RESEARCH文献大全abstract::Immunization with inactivated autoreactive T cells is an effective therapeutic approach to ameliorating autoimmune diseases, while the underlying mechanisms that regulate autoreactive T cells are not completely understood. This study tested the hypothesis that T-cell vaccination (TCV) inhibits autoimmune diabetes in m...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2011.74
更新日期:2011-09-01 00:00:00
abstract::Various systems by using electric pulse, calcium, or polyethylene glycol have been developed in the past decade for the in vitro fusion of plant gametes. These in vitro systems provide a new way to study the fertilization mechanisms of plants. In this study, we developed a bovine serum albumin (BSA)-mediated fusion sy...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/sj.cr.7290343
更新日期:2005-09-01 00:00:00
abstract::MicroRNA (miRNA) biogenesis is finely controlled by complex layers of post-transcriptional regulators, including RNA-binding proteins (RBPs). Here, we show that an RBP, QKI5, activates the processing of primary miR-124-1 (pri-124-1) during erythropoiesis. QKI5 recognizes a distal QKI response element and recruits Micr...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2017.26
更新日期:2017-03-01 00:00:00
abstract::Neural crest (NC) cells are a migratory cell population synonymous with vertebrate evolution. They generate a wide variety of cell and tissue types during embryonic and adult development including cartilage and bone, connective tissue, pigment and endocrine cells as well as neurons and glia amongst many others. Such i...
journal_title:Cell research
pub_type: 杂志文章,评审
doi:10.1038/cr.2012.11
更新日期:2012-02-01 00:00:00
abstract::Tumor initiation and growth depend on its microenvironment in which cancer-associated fibroblasts (CAFs) in tumor stroma play an important role. Prostaglandin E2 (PGE2) and interleukin (IL)-6 signal pathways are involved in the crosstalk between tumor and stromal cells. However, how PGE2-mediated signaling modulates t...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2015.51
更新日期:2015-05-01 00:00:00
abstract::KDR (kinase insert domain receptor) phosphorylation induces several effects which lead eventually to cell proliferation and survival. The precise mechanisms by which KDR, once it is activated, communicates with the nucleus are starting to be understood but have not yet been completely unravelled. Two in vitro studies ...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/sj.cr.7310012
更新日期:2006-01-01 00:00:00
abstract::The nuclear pore complex (NPC) exhibits structural plasticity and has only been characterized at local resolutions of up to 15 Å for the cytoplasmic ring (CR). Here we present a single-particle cryo-electron microscopy (cryo-EM) structure of the CR from Xenopus laevis NPC at average resolutions of 5.5-7.9 Å, with loca...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/s41422-020-0319-4
更新日期:2020-06-01 00:00:00
abstract::The endoplasmic reticulum (ER) is composed of the nuclear envelope, perinuclear sheets and a peripheral tubular network. The peripheral ER and mitochondria form tight contacts at specific subdomains, which coordinate the functions of the two organelles and are required for multiple cellular processes such as Ca2+ tran...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/s41422-018-0065-z
更新日期:2018-08-01 00:00:00
abstract::The highly conserved polycomb group (PcG) proteins maintain heritable transcription repression of the genes essential for development from fly to mammals. However, sporadic reports imply a potential role of PcGs in positive regulation of gene transcription, although systematic investigation of such function and the un...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2016.33
更新日期:2016-05-01 00:00:00
abstract::Phytohormone abscisic acid (ABA) was critical for many plant growth and developmental processes including seed maturation, germination and response to environmental factors. With the purpose to detect the possible ABA related signal transduction pathways, we tried to isolate ABA-regulated genes through cDNA macroarray...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/sj.cr.7290151
更新日期:2003-02-01 00:00:00
abstract::Influenza A viruses (IAVs), particularly H1N1, H5N1 and H7N9, pose a substantial threat to public health worldwide. Here, we report that MIR2911, a honeysuckle (HS)-encoded atypical microRNA, directly targets IAVs with a broad spectrum. MIR2911 is highly stable in HS decoction, and continuous drinking or gavage feedin...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2014.130
更新日期:2015-01-01 00:00:00
abstract::We found T-type calcium channel blocker Ni2+ can efficiently induce the formation of cement gland in Xenopus laevis animal cap explants. Another T-type specific calcium channel blocker Amiloride can also induce the formation of cement gland, while L-type specific calcium channel blocker Nifedipine has no inductive eff...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/sj.cr.7290007
更新日期:1999-03-01 00:00:00
abstract::Differentiation of inflammatory macrophages from monocytes is characterized by an orderly integration of epigenetic and transcriptional regulatory mechanisms guided by lineage-determining transcription factors such as PU.1. Further activation of macrophages leads to a stimulus- or microenvironment-specific signal inte...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2016.1
更新日期:2016-02-01 00:00:00
abstract::Neural stem cells (NSCs) constitute the cellular basis for embryonic brain development and neurogenesis. The process is regulated by NSC niche including neighbor cells such as vascular and glial cells. Since both vascular and glial cells secrete vascular endothelial growth factor (VEGF) and basic fibroblast growth fac...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/sj.cr.7310126
更新日期:2007-01-01 00:00:00
abstract::A novel ribosome-inactivating protein designated Moschatin from the mature seeds of pumpkin (Cucurbita moschata) has been successively purified to homogeneity, using ammonium sulfate precipitation, CM-cellulose 52 column chromatography, Blue Sepharose CL-6B Affinity column chromatography and FPLC size-exclusion column...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/sj.cr.7290182
更新日期:2003-10-01 00:00:00
abstract::The impairment of mitochondrial bioenergetics, often coupled with exaggerated reactive oxygen species (ROS) production, is a fundamental disease mechanism in organs with a high demand for energy, including the heart. Building a more robust and safer cellular powerhouse holds the promise for protecting these organs in ...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/s41422-019-0208-x
更新日期:2019-09-01 00:00:00
abstract::Circular RNAs (circRNAs) were only recently discovered as a new class of noncoding RNAs, functionally still largely uncharacterized. Three publications that appeared concurrently in Cell Research and Molecular Cell provide initial evidence for certain endogenous circRNAs coding for proteins. ...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2017.70
更新日期:2017-06-01 00:00:00
abstract::The functional roles of memory B and T lymphocytes underlie the phenomenal success of prophylactic vaccinations, which have decreased morbidities and mortalities from infectious diseases globally over the last 50 years. However, it is becoming increasingly appreciated that memory cells are also capable of mediating th...
journal_title:Cell research
pub_type: 杂志文章,评审
doi:10.1038/cr.2009.140
更新日期:2010-01-01 00:00:00
abstract::A recent study led by Professor Rob Martienssen in Cell showed that 3'-tRNA-derived small RNAs can suppress long terminal repeat retrotransposon activity in mammalian cells by mechanisms independent of DNA-associated epigenetic marks, suggesting how the genome may defend itself from retrotransposon invasion during epi...
journal_title:Cell research
pub_type: 评论,杂志文章
doi:10.1038/cr.2017.109
更新日期:2017-11-01 00:00:00
abstract::Leptin is the protein product encoded by the obese (ob) gene. It is a circulating hormone produced primarily by the adipose tissue. ob/ob mice with mutations of the gene encoding leptin become morbidly obese, infertile, hyperphagic, hypothermic, and diabetic. Since the cloning of leptin in 1994, our knowledge in body ...
journal_title:Cell research
pub_type: 杂志文章,评审
doi:10.1038/sj.cr.7290038
更新日期:2000-06-01 00:00:00
abstract::Polymerase I and transcript release factor (PTRF, also known as Cavin-1) is an essential component in the biogenesis and function of caveolae. Here, we show that PTRF expression is increased in senescent human fibroblasts. Importantly, overexpression of PTRF induced features characteristic of cellular senescence, wher...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2011.56
更新日期:2011-07-01 00:00:00
abstract::In mammals, the inheritance of mitochondrion and its DNA (mtDNA) is strictly maternal, despite the fact that a sperm can inject up to 100 functional mitochondria into the oocyte during fertilization. The mechanisms responsible for the elimination of the paternal mitochondria remain largely unknown. We report here that...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2011.182
更新日期:2011-12-01 00:00:00
abstract::Breast cancer is a heterogeneous disease. In particular, triple-negative breast cancer (TNBC) comprises various molecular subgroups with unclear identities and currently has few targeted treatment options. Our previous study identified protein C receptor (Procr) as a surface marker on mammary stem cells (MaSCs) locate...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/s41422-019-0225-9
更新日期:2019-10-01 00:00:00
abstract::Bone-marrow-derived mesenchymal stem cells (MSCs) have been shown to possess immunosuppressive properties, e.g., by inhibiting T cell proliferation. Activated T cells can also enhance the immunosuppression ability of MSCs. The precise mechanisms underlying MSC-mediated immunosuppression remain largely undefined, altho...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2008.80
更新日期:2008-08-01 00:00:00
abstract::Multipotent neural stem/progenitor cells hold great promise for cell therapy. The reprogramming of fibroblasts to induced pluripotent stem cells as well as mature neurons suggests a possibility to convert a terminally differentiated somatic cell into a multipotent state without first establishing pluripotency. Here, w...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2011.175
更新日期:2012-01-01 00:00:00
abstract::In order to analyze the mechanism of immuno-modulation by LPS on murine peritoneal suppressor macrophages, we have, using RNase protection assay, checked the changes of mRNA expression pattern of several cytokine genes during the immuno-modulation. It has been found that, after treating peritoneal suppressor macrophag...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.1998.32
更新日期:1998-12-01 00:00:00
abstract::The term epigenetics refers to heritable changes not encoded by DNA. The organization of DNA into chromatin fibers affects gene expression in a heritable manner and is therefore one mechanism of epigenetic inheritance. Large parts of eukaryotic genomes consist of constitutively highly condensed heterochromatin, import...
journal_title:Cell research
pub_type: 杂志文章,评审
doi:10.1038/cr.2009.13
更新日期:2009-03-01 00:00:00
abstract::A potential link between inflammation and cancer has been suspected for over a century, but the exact molecular mechanisms connecting the two remained nebulous. We proposed that NF-kappaB transcription factors regulated via the IkappaB kinase (IKK) complex play a critical role in coupling inflammation and cancer and h...
journal_title:Cell research
pub_type: 杂志文章,评审
doi:10.1038/cr.2008.30
更新日期:2008-03-01 00:00:00
abstract::Enucleation of erythroblasts during terminal differentiation is unique to mammals. Although erythroid enucleation has been extensively studied, only a few genes, including retinoblastoma protein (Rb), have been identified to regulate nuclear extrusion. It remains largely undefined by which signaling molecules, the ext...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2011.159
更新日期:2012-03-01 00:00:00
abstract::MSH5, a member of the MutS homolog DNA mismatch repair protein family, has been shown to be required for proper homologous chromosome recombination in diverse organisms such as mouse, budding yeast and Caenorhabditis elegans. In this paper, we show that a mutant Arabidopsis plant carrying the putative disrupted AtMSH5...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2008.44
更新日期:2008-05-01 00:00:00