Impaired reproduction in transgenic mice overexpressing Gamma-aminobutyric acid transporter I (GAT1).

abstract：:Protein ubiquitination by E3 ubiquitin ligases plays an important role in cancer development. In this study, we provide experimental evidence that a RING-finger-containing protein RNF13 is an ER/Golgi membrane-associated E3 ubiquitin ligase and its RING finger domain is required for the ubiquitin ligase activity. Immu...

journal_title：Cell research

authors： Zhang Q,Meng Y,Zhang L,Chen J,Zhu D

更新日期：2009-03-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Cell research

authors： Wang MS,Thakur M,Peng MS,Jiang Y,Frantz LAF,Li M,Zhang JJ,Wang S,Peters J,Otecko NO,Suwannapoom C,Guo X,Zheng ZQ,Esmailizadeh A,Hirimuthugoda NY,Ashari H,Suladari S,Zein MSA,Kusza S,Sohrabi S,Kharrati-Koopaee H,

更新日期：2020-09-01 00:00:00

abstract：:Drosophila Wingless (Wg) acts as a morphogen during development. Wg secretion is controlled by a seven-pass transmembrane cargo Wntless (Wls). We have recently identified retromer as a key regulator involved in Wls trafficking. As sorting nexin (SNX) molecules are essential components of the retromer complex, we hypot...

journal_title：Cell research

authors： Zhang P,Wu Y,Belenkaya TY,Lin X

更新日期：2011-12-01 00:00:00

abstract：:Brain tumors are dynamic complex ecosystems with multiple cell types. To model the brain tumor microenvironment in a reproducible and scalable system, we developed a rapid three-dimensional (3D) bioprinting method to construct clinically relevant biomimetic tissue models. In recurrent glioblastoma, macrophages/microgl...

journal_title：Cell research

authors： Tang M,Xie Q,Gimple RC,Zhong Z,Tam T,Tian J,Kidwell RL,Wu Q,Prager BC,Qiu Z,Yu A,Zhu Z,Mesci P,Jing H,Schimelman J,Wang P,Lee D,Lorenzini MH,Dixit D,Zhao L,Bhargava S,Miller TE,Wan X,Tang J,Sun B,Cravatt

更新日期：2020-10-01 00:00:00

abstract：:A novel ribosome-inactivating protein designated Moschatin from the mature seeds of pumpkin (Cucurbita moschata) has been successively purified to homogeneity, using ammonium sulfate precipitation, CM-cellulose 52 column chromatography, Blue Sepharose CL-6B Affinity column chromatography and FPLC size-exclusion column...

journal_title：Cell research

authors： Xia HC,Li F,Li Z,Zhang ZC

更新日期：2003-10-01 00:00:00

abstract：:Members of the basic helix-loop-helix (bHLH) gene family play important roles in vertebrate neurogenesis. In this study, confocal microscopy-based fluorescence resonance energy transfer (FRET) is used to monitor bHLH protein-protein interactions under various physiological conditions. Tissue-specific bHLH activators, ...

journal_title：Cell research

authors： Wang C,Bian W,Xia C,Zhang T,Guillemot F,Jing N

更新日期：2006-06-01 00:00:00

abstract：:Polymerase I and transcript release factor (PTRF, also known as Cavin-1) is an essential component in the biogenesis and function of caveolae. Here, we show that PTRF expression is increased in senescent human fibroblasts. Importantly, overexpression of PTRF induced features characteristic of cellular senescence, wher...

journal_title：Cell research

authors： Bai L,Deng X,Li J,Wang M,Li Q,An W,A D,Cong YS

更新日期：2011-07-01 00:00:00

abstract：:Recent evidence indicates that codon optimality is a broad determinant of mRNA stability. A study by Radhakrishnan et al. in Cell raises the possibility that the conserved DEAD-box protein Dhh1 underlies the phenomenon. ...

journal_title：Cell research

authors： Harigaya Y,Parker R

更新日期：2016-12-01 00:00:00

abstract：:Various systems by using electric pulse, calcium, or polyethylene glycol have been developed in the past decade for the in vitro fusion of plant gametes. These in vitro systems provide a new way to study the fertilization mechanisms of plants. In this study, we developed a bovine serum albumin (BSA)-mediated fusion sy...

journal_title：Cell research

authors： Peng XB,Sun MX,Yang HY

更新日期：2005-09-01 00:00:00

abstract：:The muscle protein myosin binding protein C (MyBPC) is a large multi-domain protein whose role in the sarcomere is complex and not yet fully understood. Mutations in MyBPC are strongly associated with the heart disease familial hypertrophic cardiomyopathy (FHC) and these experiments of nature have provided some insigh...

journal_title：Cell research

authors： Oakley CE,Hambly BD,Curmi PM,Brown LJ

更新日期：2004-04-01 00:00:00

abstract：:We found T-type calcium channel blocker Ni2+ can efficiently induce the formation of cement gland in Xenopus laevis animal cap explants. Another T-type specific calcium channel blocker Amiloride can also induce the formation of cement gland, while L-type specific calcium channel blocker Nifedipine has no inductive eff...

journal_title：Cell research

authors： Huang Y,Ding XY

更新日期：1999-03-01 00:00:00

abstract：:Mouse cloning from fertilized eggs can assist development of approaches for the production of "genetically tailored" human embryonic stem (ES) cell lines that are not constrained by the limitations of oocyte availability. However, to date only zygotes have been successfully used as recipients of nuclei from terminally...

journal_title：Cell research

authors： Riaz A,Zhao X,Dai X,Li W,Liu L,Wan H,Yu Y,Wang L,Zhou Q

更新日期：2011-05-01 00:00:00

abstract：:Critical epigenetic regulation of primate embryogenesis entails DNA methylome changes. Here we report genome-wide composition, patterning, and stage-specific dynamics of DNA methylation in pre-implantation rhesus monkey embryos as well as male and female gametes studied using an optimized tagmentation-based whole-geno...

journal_title：Cell research

authors： Gao F,Niu Y,Sun YE,Lu H,Chen Y,Li S,Kang Y,Luo Y,Si C,Yu J,Li C,Sun N,Si W,Wang H,Ji W,Tan T

更新日期：2017-04-01 00:00:00

abstract：:Implantation involves complex signaling networks, which direct morphological and molecular transformation of the embryo and the uterus and establish the trajectory of normal pregnancy. The recent work by Zhang et al. published in Cell Research, identifies the transcriptional regulator, Rbpj, as essential for uterine c...

journal_title：Cell research

authors： Robinson JF,Fisher SJ

更新日期：2014-09-01 00:00:00

abstract：:Recent studies on enzymes and reader proteins for histone crotonylation support a function of histone crotonylation in transcription. However, the enzyme(s) responsible for histone decrotonylation (HDCR) remains poorly defined. Moreover, it remains to be determined if histone crotonylation is physiologically significa...

journal_title：Cell research

authors： Wei W,Liu X,Chen J,Gao S,Lu L,Zhang H,Ding G,Wang Z,Chen Z,Shi T,Li J,Yu J,Wong J

更新日期：2017-07-01 00:00:00

abstract：:The Beclin 1 gene is a haplo-insufficient tumor suppressor and plays an essential role in autophagy. However, the molecular mechanism by which Beclin 1 functions remains largely unknown. Here we report the crystal structure of the evolutionarily conserved domain (ECD) of Beclin 1 at 1.6 Å resolution. Beclin 1 ECD exhi...

journal_title：Cell research

authors： Huang W,Choi W,Hu W,Mi N,Guo Q,Ma M,Liu M,Tian Y,Lu P,Wang FL,Deng H,Liu L,Gao N,Yu L,Shi Y

更新日期：2012-03-01 00:00:00

abstract：:Generation of widely differing and specialized cell types from a single totipotent zygote involves large-scale transcriptional changes and chromatin reorganization. Pioneer transcription factors play key roles in programming the epigenome and facilitating recruitment of additional regulatory factors during successive ...

journal_title：Cell research

authors： Gao R,Liang X,Cheedipudi S,Cordero J,Jiang X,Zhang Q,Caputo L,Günther S,Kuenne C,Ren Y,Bhattacharya S,Yuan X,Barreto G,Chen Y,Braun T,Evans SM,Sun Y,Dobreva G

更新日期：2019-06-01 00:00:00

abstract：:Plant reproduction is initiated by the specification of sporocytes that form haploid spores through meiosis. A new study in Arabidopsis published in Cell Research shows how the product of sporocyteless/nozzle, a key gene in this process, partners with co-repressors and transcription factors to promote spore formation,...

journal_title：Cell research

authors： Yuan L,Sundaresan V

更新日期：2015-01-01 00:00:00

abstract：:DNA replication stress, a feature of human cancers, often leads to instability at specific genomic loci, such as the common fragile sites (CFSs). Cells experiencing DNA replication stress may also exhibit mitotic DNA synthesis (MiDAS). To understand the physiological function of MiDAS and its relationship to CFSs, we ...

journal_title：Cell research

authors： Macheret M,Bhowmick R,Sobkowiak K,Padayachy L,Mailler J,Hickson ID,Halazonetis TD

更新日期：2020-11-01 00:00:00

abstract：:Apoptosis is a complex process involving a large array of genes and mutation of any of these genes may lead to malignancy formation. Re-acquirement of FasL by tumor cells may enable them to evade the surveillance of immune system and thus contributes to the growth of tumor. Apart from traditional therapies, inducing a...

journal_title：Cell research

authors： Fan XQ,Guo YJ

更新日期：2001-03-01 00:00:00

abstract：:A recent paper in Nature shows that tumor exosomes expressing unique integrins can determine organotropic metastasis by preparing pre-metastatic niche through their integrins-mediated fusion with and fertilization of organ-specific resident cells. ...

journal_title：Cell research

authors： Liu Y,Cao X

更新日期：2016-02-01 00:00:00

abstract：:In searching for differentially expressed genes in human uterine leiomyomas (ULs), suppression subtractive hybridization was used to construct an UL up-regulated library, which turned out to represent 88 genes. After two rounds of screening by reverse Northern analysis, twenty genes were proved to be up-regulated, inc...

journal_title：Cell research

authors： Li B,Zhang YL

更新日期：2002-09-01 00:00:00

abstract：:The 5' fragment (1 647 bp) of the cotton glucuronosyltransferase gene (GhGlcAT1) was transcriptionally fused to the beta-glucuronidase (GUS) gene, and functionally analyzed for important regulatory regions controlling gene expression in transgenic tobacco plants. GUS activity analysis revealed that the full-length pro...

journal_title：Cell research

authors： Wu AM,Lv SY,Liu JY

更新日期：2007-02-01 00:00:00

abstract：:Hedgehog (Hh) signaling plays vital roles in animal development and tissue homeostasis, and its misregulation causes congenital diseases and several types of cancer. Suppressor of Fused (Su(fu)) is a conserved inhibitory component of the Hh signaling pathway, but how it is regulated remains poorly understood. Here we ...

journal_title：Cell research

authors： Liu C,Zhou Z,Yao X,Chen P,Sun M,Su M,Chang C,Yan J,Jiang J,Zhang Q

更新日期：2014-05-01 00:00:00

abstract：:International non-governmental organizations were among the first international actors that responded to the emergence of AIDS crisis in China. Since 1994, the number of international non-governmental organizations and charitable foundations working in AIDS related issue areas in China has grown steadily and substanti...

journal_title：Cell research

authors： Wu FS

更新日期：2005-11-01 00:00:00

abstract：:Transfer RNA (tRNA) is present at tens of millions of transcripts in a human cell and is the most abundant RNA in moles among all cellular RNAs. tRNA is also the most extensively modified RNA with, on an average, 13 modifications per molecule. The primary function of tRNA as the adaptor of amino acids and the genetic ...

journal_title：Cell research

authors： Pan T

更新日期：2018-04-01 00:00:00

abstract：:The completion of genome sequences and subsequent high-throughput mapping of molecular networks have allowed us to study biology from the network perspective. Experimental, statistical and mathematical modeling approaches have been employed to study the structure, function and dynamics of molecular networks, and begin...

journal_title：Cell research

authors： Han JD

更新日期：2008-02-01 00:00:00

abstract：:Gonad development requires a coordinated soma-germline interaction that ensures renewal and differentiation of germline and somatic stem cells to ultimately produce mature gametes. The Drosophila tumour suppressor gene discs large (dlg) encodes a septate junction protein functioning during epithelial polarization, asy...

journal_title：Cell research

authors： Papagiannouli F,Mechler BM

更新日期：2009-10-01 00:00:00

abstract：:Naïve CD4 T cells can differentiate into at least two different types of T helpers, Th1 and Th2 cells. Th2 cells, capable of producing IL-4, IL-5 and IL-13, are involved in humoral immunity against extracellular pathogens and in the induction of asthma and other allergic diseases. In this review, we summarize recent r...

journal_title：Cell research

authors： Zhu J,Yamane H,Cote-Sierra J,Guo L,Paul WE

更新日期：2006-01-01 00:00:00

abstract：:While N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic mRNA, is linked to cell differentiation and tissue development, the biological significance of m6A modification in mammalian glial development remains unknown. Here, we identify a novel m6A reader, Prrc2a (Proline rich coiled-coil 2 ...

journal_title：Cell research

authors： Wu R,Li A,Sun B,Sun JG,Zhang J,Zhang T,Chen Y,Xiao Y,Gao Y,Zhang Q,Ma J,Yang X,Liao Y,Lai WY,Qi X,Wang S,Shu Y,Wang HL,Wang F,Yang YG,Yuan Z

更新日期：2019-01-01 00:00:00