Abstract：
:Literature on the development of the human vagina is abundant; however, contributions concerning the prenatal development of the entire utero-vaginal anlagen (UVA) are rare or carried out in rodents. The primary epithelial characteristics in the adult vagina and uterus are determined during prenatal development and depend on epithelio-mesenchymal stroma interaction; thus an investigation summarizing the spatiotemporal distribution of relevant molecular markers in the entire human UVA will be of current interest. We phenotyped epithelial and mesenchymal characteristics in sagittal sections from 24 female fetuses of 14-34 weeks of gestation and two female newborns by immunostaining with cytokeratins 8, 13, 14 and 17, p63, bcl-2, bmp4, HOX A13, CD31, VEGF, SMA, Pax2 and vimentin. Epithelial differentiation followed a caudal-to-cranial direction in the UVA. Due to the cytokeratin profile of cytokeratins 8, 13 and 14, the characteristics of the different epithelial zones in the UVA could already be recognized in middle-age fetuses. Vaginal epithelium originated from the urogenital sinus in the lower portion and initiated the transformation of vimentin-positive Müllerian epithelium in the upper vaginal portion. During prenatal development the original squamo-columnar junction was clearly detectable from week 24 onwards and was always found in the cervical canal. Early blc-2 positivity within the surrounding mesenchyme of the entire vagina including the portio region pointed to an organ-specific mesenchymal influence. Prenatal findings in human specimens clearly show that fornix epithelium up to the squamo-columnar junction is of vaginal Müllerian origin, and the cervical epithelium cranial to the squamo-columnar junction is of uterine Müllerian origin and includes cells with enough plasticity to transform into squamous epithelium.
journal_name
J Anatjournal_title
Journal of anatomyauthors
Fritsch H,Hoermann R,Bitsche M,Pechriggl E,Reich Odoi
10.1111/joa.12029subject
Has Abstractpub_date
2013-04-01 00:00:00pages
462-72issue
4eissn
0021-8782issn
1469-7580journal_volume
222pub_type
杂志文章abstract：:The differentiation of granulated metrial gland (GMG) cells has been investigated during deciduomata formation in radiation-induced chimeric mice reconstituted with rat or mouse bone marrow. The extent of the decidual reaction was apparently normal in regions of the uterine horns shielded from the irradiation but was ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1984-12-01 00:00:00
abstract：:The distribution of neurons expressing NADPH diaphorase activity was examined histochemically in whole mount preparations of the neonatal guinea pig urinary bladder. NADPH diaphorase positive neurons were abundant in the intramural ganglia in both the detrusor and trigone regions of the bladder. Labelled nerve fibres ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1994-12-01 00:00:00
abstract：:Enzymatic degradation followed by lectin application was carried out on specimens of the rabbit oviduct. The sequential application of the glycosidases (neuraminidase, alpha-L-fucosidase, beta-galactosidase and alpha-mannosidase) and lectins (peanut, winged pea, wheat germ and soybean) seem promising as an effective m...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1985-06-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1989-04-01 00:00:00
abstract：:The koala has an inguinoaxillary lymph trunk on either side of the ventral midline, and this carries efferent lymph from the superficial inguinal lymph node directly to the deep axillary lymph node. The superficial lymph nodes are large and soft compared with those of the domestic species, and each lymph centre usuall...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1991-08-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1976-02-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1979-03-01 00:00:00
abstract：:The effects of excess iodine on the development of the thyroid gland of chick embryos was assessed following injections of potassium iodide prior to incubation. Iodide injection resulted in a significantly greater thyroid gland weight (goitre) on Day 18 of incubation and a delay in hatching. Histological studies of th...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1991-06-01 00:00:00
abstract：:The developing human brain can compensate for pre- and perinatally acquired focal lesions more effectively than the adult brain. The mechanisms by which this effective reorganization is achieved vary considerably between different functional systems, reflecting differences in the normal maturation of these systems. In...
journal_title：Journal of anatomy
pub_type： 杂志文章,评审
doi：10.1111/j.1469-7580.2010.01262.x
更新日期：2010-10-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2012.01513.x
更新日期：2012-07-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.13091
更新日期：2020-02-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1996-02-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12575
更新日期：2017-04-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1993-06-01 00:00:00
abstract：:It is currently thought that New World monkeys, prosimians, and humans are the only primates to possess vomeronasal organs (VNOs) as adults. Recent studies of the human VNO suggest that previous investigations on Old World primates may have missed the VNO. We examined nasal septa from the chimpanzee (Pan troglodytes) ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.2001.19810077.x
更新日期：2001-01-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章,评审
doi：10.1111/joa.12117
更新日期：2014-03-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2011.01436.x
更新日期：2011-12-01 00:00:00
abstract：:The distribution of mRNAs and antigens of tissue type (t) and urokinase type (u) plasminogen activators (PA) plus their corresponding inhibitors, type-1 (PAI-1) and type-2 (PAI-2) were studied in human and rhesus monkey placentae by in situ hybridisation and immunocytochemistry. Specific monkey cRNA and antibodies aga...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.1999.19420183.x
更新日期：1999-02-01 00:00:00
abstract：:The effect of serum prolactin elevation on the growth and development of the rat breast was investigated. Oral administration of the dopamine antagonist, perphenazine, led to a 5-10-fold elevation of serum prolactin after two days of treatment which was maintained for the 54 days of study. A significant (P less than 0...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1989-02-01 00:00:00
abstract：:Mammalian Langerhans cells (LC) are epidermal dendritic cells which originate in bone marrow and migrate toward the T cell area of lymph nodes, where they act as professional antigen-presenting cells. A variety of cell surface markers, such as the ectoenzyme adenosine triphosphatase (ATPase), Ia and CDla antigens, hav...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.2001.19940493.x
更新日期：2001-10-01 00:00:00
abstract：:The blood supply to the cranial venae cavae on both sides and to the heart was studied macroscopically in 40 adult laboratory shrews (Suncus murinus) of both sexes injected either with Neoprene latex into the abdominal aorta (25 animals) or with Mercox into the left ventricle (15 animals). The 1st branch of the left s...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1993-12-01 00:00:00
abstract：:The occurrence of pneumatisation in the skull of the adult domestic fowl was investigated in eight birds by gross and histological examination. It was found to occur regularly throughout the neurocranium and in the quadrate and variably in the mandible, but to be absent in the facial skeleton. Close agreement was foun...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1984-06-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1983-06-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.13302
更新日期：2021-01-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1994-12-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1985-03-01 00:00:00
abstract：:The total numbers of fibres in transverse histological sections of the pterygoid muscles of Lister rats of various ages were counted on enlarged photomicrographic prints. The number in the medial pterygoid of the male doubled between birth and six weeks. This was followed by a decrease of rather more than 10 percent i...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1975-04-01 00:00:00
abstract：:The inner thoracic cavity is lined by the parietal pleura, and the lung lobes are covered by the visceral pleura. The parietal and visceral plurae form the pleural cavity that has negative pressure within to enable normal respiration. The lung tissues are bilaterally innervated by vagal and spinal nerves, including se...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12560
更新日期：2017-02-01 00:00:00
abstract：:The brain-derived neurotrophic factor (BDNF) gene is expressed in differentiating and post-mitotic neurons of the zebrafish embryo, where it has been implicated in Huntington's disease. Little is known, however, about the full complement of neuronal cell types that express BDNF in this important vertebrate model. Here...
journal_title：Journal of anatomy
pub_type： 杂志文章
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更新日期：2014-05-01 00:00:00
abstract：:Substantial changes in bone histology accompany the secondary adaptation to life in the water. This transition is well documented in several lineages of mammals and non-avian reptiles, but has received relatively little attention in birds. This study presents new observations on the long bone microstructure of penguin...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12367
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