Abstract:
:The distribution of mRNAs and antigens of tissue type (t) and urokinase type (u) plasminogen activators (PA) plus their corresponding inhibitors, type-1 (PAI-1) and type-2 (PAI-2) were studied in human and rhesus monkey placentae by in situ hybridisation and immunocytochemistry. Specific monkey cRNA and antibodies against human tPA, uPA, PAI-1 and PAI-2 were used as probes. The following results were obtained. (1) All the molecules tPA, uPA, PAI-1 and PAI-2 and their mRNAs were identified in the majority of the extravillous cytotrophoblast cells of the decidual layer between Rohr's and Nitabuch's striae and in cytotrophoblast cells of the chorionic plate, basal plate, intercotyledonary septae and cytotrophoblast cells of the chorionic villous tree. (2) Expression of uPA and PAI-2 was noted in villous trophoblast whereas tPA and PAI-1 were mainly concentrated where detachment from maternal tissue occurs. (3) No expression of tPA, uPA, PAI-1 and PAI-2 was observed in the basal plate endometrial stromal cells, chorionic plate connective tissue cells, septal endometrial stromal cells or villous core mesenchyme. (4) The distribution of probes observed following in situ hybridisation is generally consistent with the immunofluorescence pattern of the corresponding antigens and no significant interspecies differences were noted. It is possible that both decidual and extravillous trophoblast cells of placentae of human and rhesus monkey are capable of producing tPA, uPA, PAI-1 and PAI-2 to differing extents. Coordinated expression of these genes in the tissue may play an essential role in the maintenance of normal placentation and parturition. The differences in distribution we observed are consistent with the suggestion that coordinated expression of tPA and its inhibitor PAI-1 may play a key role in fibrinolytic activity in the early stages of placentation and separation of placenta from maternal tissue at term. On the other hand, uPA with its inhibitor PAI-2 appears mainly to play a role in degradation of trophoblast cell-associated extracellular matrix, and thus may be of greatest importance during early stages of placentation.
journal_name
J Anatjournal_title
Journal of anatomyauthors
Hu ZY,Liu YX,Liu K,Byrne S,Ny T,Feng Q,Ockleford CDdoi
10.1046/j.1469-7580.1999.19420183.xkeywords:
subject
Has Abstractpub_date
1999-02-01 00:00:00pages
183-95eissn
0021-8782issn
1469-7580journal_volume
194 ( Pt 2)pub_type
杂志文章abstract::The architecture of the fibres in the sciatic nerve of the dog has been analysed by following the degeneration of fibres resulting from division of the individual spinal nerves which contribute to the sciatic nerve. A pattern has been demonstrated which varies in part with the size of the contribution to the sciatic n...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1978-10-01 00:00:00
abstract::Premature closure of the sagittal suture occurs as an isolated (nonsyndromic) birth defect or as a syndromic anomaly in combination with other congenital dysmorphologies. The genetic causes of sagittal nonsyndromic craniosynostosis (NSC) remain unknown. Although variation of the dysmorphic (scaphocephaly) skull shape ...
journal_title:Journal of anatomy
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1469-7580.2010.01258.x
更新日期:2010-08-01 00:00:00
abstract::The spatiotemporal distribution of macrophages in the uterine wall of mice in the second half of pregnancy and the early postpartum period has been studied. Macrophages were identified using a combination of morphological criteria, the capacity to endocytose horseradish peroxidase and the expression of the Mac-1 antig...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1992-08-01 00:00:00
abstract::As the uterus enlarges to accommodate the growing fetus during pregnancy, the cervix behaves essentially as a barrier. During ripening and delivery, it needs to become soft and distensible to allow dilation and the passage of the conceptus. As the transformations of the collagen-containing fibres are known to be essen...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1046/j.1469-7580.2003.00227.x
更新日期:2003-10-01 00:00:00
abstract::In stem-cell research a major difficulty is caused by the lack of distinctive features that allow the identification of human mesenchymal stem cells (hMSC). Until now, there has been no specific marker and the most common way to identify hMSC is by their characteristic stem-cell properties: self-replication and differ...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2004.00252.x
更新日期:2004-02-01 00:00:00
abstract::Invasive species are a global scourge and often negatively impact native species. Understanding the expansion and dispersal limits of these species is essential. As previous studies have demonstrated increased locomotor performance for populations at the edge of the range of expanding populations, studies of locomotio...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.13063
更新日期:2019-12-01 00:00:00
abstract::The paraspinal compartment acts as a bone-muscle composite beam of the spine. The elastic properties of the paraspinal muscles play a critical role in spine stabilization. These properties depend on the subjects' posture, and they may be drastically altered by low back pain. Supersonic shear wave elastography can be u...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12978
更新日期:2019-06-01 00:00:00
abstract::The arteries of the skin have been postulated to form a profound plexus at the dermal/hypodermal junction and a superficial plexus in the papillary dermis. Our article aims to rebut this concept and to provide an alternative description of the arrangement of the dermal arteries. Employing a novel technique, we produce...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12113
更新日期:2013-12-01 00:00:00
abstract::Normal human kidneys were examined for the presence of granular peripolar cells. The prominent feature of the human peripolar cell was the presence of numerous cytoplasmic membrane-bound granules, which had the appearance of secretory granules. Most of the granules had a homogeneous matrix with no crystalline substruc...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1986-06-01 00:00:00
abstract::Serial thin sections of the coronal dental pulp of the cat's canine tooth were cut. Parts of the sub-odontoblastic neural plexus were photographed from 100 of the sections. The plexus consists of many slender, predominantly unmyelinated nerve fibres. Many axons are incompletely sheathed by their Schwann cell. Some axo...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1980-05-01 00:00:00
abstract::The feet of apes have a different morphology from those of humans. Until now, it has merely been assumed that the morphology seen in humans must be adaptive for habitual bipedal walking, as the habitual use of bipedal walking is generally regarded as one of the most clear-cut differences between humans and apes. This ...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12201
更新日期:2014-08-01 00:00:00
abstract::Vascular sympathetic neuroeffector associations have been examined in rat iris arterioles using serial section electron microscopy and reconstruction techniques. Examination of random sections showed that, of all profiles of varicosities (199) seen to lie closer than 4 microns to vascular smooth muscle cells, only a s...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1046/j.1469-7580.1998.19210045.x
更新日期:1998-01-01 00:00:00
abstract::The fabella is a sesamoid bone located in the gastrocnemius behind the lateral femoral condyle. In humans, fabellae are 3.5 times more common today than they were 100 years ago, with prevalence rates varying between and within populations. In particular, fabellae have been assumed to be more common in Asians than non-...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.13091
更新日期:2020-02-01 00:00:00
abstract::Blind mole-rats (Spalax ehrenbergi) are fossorial solitary rodents that present striking morphological, physiological and behavioural adaptations to the subterranean environment in which they live. Previous studies have shown that mole-rats are specialised in tooth-digging. The rapid eruption-rate of their incisors ha...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1046/j.1469-7580.2001.19950591.x
更新日期:2001-11-01 00:00:00
abstract::Femoral neck fractures are a major cause of morbidity and mortality in elderly humans. In addition to the age-related loss of cancellous bone, changes to the microstructure and morphology of the metaphyseal cortex may be a contributing factor in osteoporotic hip fractures. Recent investigations have identified a hyper...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1046/j.1469-7580.2001.19820153.x
更新日期:2001-02-01 00:00:00
abstract::We have explored the innervation of the rainbow trout (O. mykiss) liver using immunohistochemical procedures and light microscopy to detect in situ protein gene product 9.5 and neuronal nitric oxide synthase immunoreactivities (PGP-IR and NOS-IR). The results showed PGP-IR nerve fibres running with the extralobular bi...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1046/j.1469-7580.1998.19320241.x
更新日期:1998-08-01 00:00:00
abstract::The study aim was to explore the anatomy, histopathology, and molecular biological function of the fascias posterior to the interperitoneal colon and its mesocolon to provide information for improving complete mesocolic excision. To accomplish this aim, we performed intraoperative observations in 60 interperitoneal co...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12066
更新日期:2013-08-01 00:00:00
abstract::Data are presented on the postnatal growth of the mouse bladder. Both bladder size (measured as surface area) and bladder wet weight increase steadily with age, respectively reaching 2.5 times and 4 times their newborn values by the age of ten weeks. Despite this growth, which may be due principally to non-urothelial ...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1985-12-01 00:00:00
abstract::A defining feature of dentitions in modern sharks and rays is the regulated pattern order that generates multiple replacement teeth. These are arranged in labio-lingual files of replacement teeth that form in sequential time order both along the jaw and within successively initiated teeth in a deep dental lamina. Two ...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12796
更新日期:2018-06-01 00:00:00
abstract::Signalling interactions between the polarizing region, which produces SHH, and the apical ectodermal ridge, which produces FGFs, are essential for outgrowth and patterning of vertebrate limbs. However, mechanisms that mediate translation of early positional information of cells into anatomy remain largely unknown. In ...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1046/j.1469-7580.2003.00134.x
更新日期:2003-01-01 00:00:00
abstract::Assessment of global endocranial morphology and regional neuroanatomical changes in early hominins is critical for the reconstruction of evolutionary trajectories of cerebral regions in the human lineage. Early evidence of cortical reorganization in specific local areas (e.g. visual cortex, inferior frontal gyrus) is ...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12745
更新日期:2018-02-01 00:00:00
abstract::Degeneration induced by intracranial section of the ophthalmic branch of the trigeminal nerve was used as a marker to trace the ocular passage and termination of fibres in ocular filtration angle structures of 3 cynomolgus monkeys. Fine supraciliary nerves branched from precorneal nerves as they entered the sclera fro...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1994-06-01 00:00:00
abstract::The structure of the sinuatrial nodal artery has been investigated in young and old rats. The nodal artery is derived from the internal thoracic artery, runs centrally though the node and supplies it by several branches. An extensive cuff of nodal cells is seen within the adventitia of the artery and its branches adja...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1980-06-01 00:00:00
abstract::The role of the neural arch in weight transmission in the cervical and upper thoracic regions of the vertebral column has been investigated. Measurements at the levels of C2, C4, C6, C7, T1 and T5 vertebrae were made in 44 adult male vertebral columns. At each level, the area of the inferior surface of the body was co...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1986-10-01 00:00:00
abstract::The distance of the neuromuscular gap was measured in a chicken smooth muscle, m. retractor phalli cranialis (MRPC). For the identification of active neuromuscular contacts, acetylcholinesterase (AChE) was stained according to Tago's modification of the Karnovsky and Roots' method. Thirty two out of 500 muscle cells w...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1990-06-01 00:00:00
abstract::The onset and evolution of the meiotic prophase were assessed by histological and cytological techniques in fetal and neonatal ovaries obtained from day 13 postcoitum to day 11 postpartum in the golden hamster (Mesocricetus auratus). The histological technique based on the Feulgen stain and the cytological technique b...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1981-06-01 00:00:00
abstract::We characterized the architecture, fiber type, titin isoform distribution, and collagen content of 27 portions of 22 muscles in the murine forelimb. The mouse forelimb was different from the human arm in that it had the extensor digitorum lateralis muscle and no brachioradialis muscle. Architecturally, the mouse forel...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2012.01559.x
更新日期:2012-11-01 00:00:00
abstract::Morphometric analysis of the kidney of the camel was carried out on gross slices and histological sections using standard morphometric methods. The renal cortex occupied about 50% by volume of the kidney, and the ratio of the thickness of the medulla to that of the cortex was about 4:1. The relative thickness of the m...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1979-08-01 00:00:00
abstract::Many vertebrates have an ocular skeleton composed of cartilage and/or bone situated within the sclera of the eye. In this study we investigated whether modern and fossil sharks have an ocular skeleton, and whether it is conserved in morphology. We describe the scleral skeletal elements of three species of modern shark...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2009.01077.x
更新日期:2009-06-01 00:00:00
abstract::The morphological transition from the simple epidermis that contacts the amniotic fluid of embryonic crocodilians to the adult epidermis required in a terrestrial environment has never been described. We used light and electron microscopy to study the development, differentiation and keratinisation of the epidermis of...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1046/j.1469-7580.2001.19830265.x
更新日期:2001-03-01 00:00:00