Digital development and morphogenesis.

Abstract:

:Signalling interactions between the polarizing region, which produces SHH, and the apical ectodermal ridge, which produces FGFs, are essential for outgrowth and patterning of vertebrate limbs. However, mechanisms that mediate translation of early positional information of cells into anatomy remain largely unknown. In particular, the molecular and cellular basis of digit morphogenesis are not fully understood, either in terms of the formation of the different digits along the antero-posterior axis or in the way digits stop growing once pattern formation has been completed. Here we will review recent data about digit development. Manipulation of morphogenetic signals during digit formation, including application of SHH interdigitally, has shown that digit primordia possess a certain plasticity, and that digit anatomy becomes irreversibly fixed during morphogenesis. The process of generation of joints and thus segmentation and formation of digit tips is also discussed.

journal_name

J Anat

journal_title

Journal of anatomy

authors

Sanz-Ezquerro JJ,Tickle C

doi

10.1046/j.1469-7580.2003.00134.x

keywords:

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

51-8

issue

1

eissn

0021-8782

issn

1469-7580

journal_volume

202

pub_type

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