Abstract:
:Proper assessment of outcome in clinical trials of neural transplantation requires both biochemical and imaging indices of graft survival, and behavioural and physiological indices of graft function. For transplantation in Huntington's disease, a variety of ligands that are selective for striatal degeneration and graft-derived replacement are available, notably ligands of dopaminergic receptors on striatal neurons. However, the validity of such ligands is potentially compromised by adjunctive drug therapies (e.g. neuroleptics) given to patients in the course of normal clinical care. We review the present state of experimental and clinical understanding of the selectivity of available ligands for striatal imaging, their interaction with other drug treatments, and strategies for refining valid assessment protocols in patients.
journal_name
J Anatjournal_title
Journal of anatomyauthors
Besret L,Kendall AL,Dunnett SBdoi
10.1046/j.1469-7580.2000.19640597.xkeywords:
subject
Has Abstractpub_date
2000-05-01 00:00:00pages
597-607eissn
0021-8782issn
1469-7580journal_volume
196 ( Pt 4)pub_type
杂志文章,评审abstract::It is well accepted that the aortic plexus is a network of pre- and post-ganglionic nerves overlying the abdominal aorta, which is primarily involved with the sympathetic innervation to the mesenteric, pelvic and urogenital organs. Because a comprehensive anatomical description of the aortic plexus and its connections...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12251
更新日期:2015-01-01 00:00:00
abstract::Experimental evidence indicates that lymph nodes in humans undergo alterations during ageing. This is clinically important because of the crucial role of these organs in the immune system and their lymph reabsorption and drainage function. Although some age-related changes in lymph node histoarchitecture have been des...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2010.01213.x
更新日期:2010-05-01 00:00:00
abstract::Little is known about the embryonic development and variation of the chondrocranium in Crocodylia and there are no works on any Caiman species. Due to the importance of cranial features in the systematics of this clade, investigating the development of the skull in embryonic stages is essential. In this study, we pres...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12968
更新日期:2019-06-01 00:00:00
abstract::Signalling interactions between the polarizing region, which produces SHH, and the apical ectodermal ridge, which produces FGFs, are essential for outgrowth and patterning of vertebrate limbs. However, mechanisms that mediate translation of early positional information of cells into anatomy remain largely unknown. In ...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1046/j.1469-7580.2003.00134.x
更新日期:2003-01-01 00:00:00
abstract::This study presents, for the first time, sequences of five beta-keratin cDNAs from turtle epidermis obtained by means of 5'- and 3'-rapid amplification of cDNA ends (RACE) analyses. The deduced amino acid sequences correspond to distinct glycine-proline-serine-tyrosine rich proteins containing 122-174 amino acids. In ...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2008.01030.x
更新日期:2009-02-01 00:00:00
abstract::The regeneration of adrenocortical autotransplants in the rat spleen has been investigated by light and electron microscopy. Up to the seventh day after implantation, adrenal grafts showed large areas of necrosis and contained many degenerating (apoptotic) adrenocortical cells, some mesenchyme-like poorly differentiat...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1982-09-01 00:00:00
abstract::Development of the neural crest involves a remarkable feat of coordinated cell migration in which cells detach from the neural tube, take varying routes of migration through the embryonic tissues and then differentiate at the end of their journey to participate in the formation of a number of organ systems. In general...
journal_title:Journal of anatomy
pub_type: 杂志文章,评审
doi:10.1046/j.1469-7580.1997.19140507.x
更新日期:1997-11-01 00:00:00
abstract::The secretory cells of the golden hamster (Mesocricetus auratus) oviductal epithelium on the day of ovulation were observed by light and electron microscopy. In the fimbriae two types of secretory cells were observed: one possessed secretory granules with electron-lucent matrices, prominent protrusions and many electr...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1991-04-01 00:00:00
abstract::Collagen fibrils from different rat tendons have been investigated by freeze-fracture and transmission electron microscopy. In all cases, marked differences in both fibril morphology and subfibrillar organisation have been consistently found between the tendon core (composed of large and heterogeneous fibrils comprisi...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1990-10-01 00:00:00
abstract::In recent years, there has been increasing demand for personalized anatomy modelling for medical and industrial applications, such as ergonomics device development, clinical radiological exposure simulation, biomechanics analysis, and 3D animation character design. In this study, we constructed deformable torso phanto...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12815
更新日期:2018-07-01 00:00:00
abstract::The fine structure of the intercellular junctions of the hen parathyroid gland was studied using freeze-fracture replicas and thin sections. In the conventional thin sections, desmosomes, intermediate junctions (maculae adherentes) and gap junctions were observed, and in the lanthanum-fixed sections, tight junctions (...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1982-09-01 00:00:00
abstract::Alx4 and Msx2 encode homeodomain-containing transcription factors that show a clear functional overlap. In both mice and humans, loss of function of either gene is associated with ossification defects of the skull vault, although the major effect is on the frontal bones in mice and the parietal bones in humans. This s...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.0021-8782.2004.00304.x
更新日期:2004-06-01 00:00:00
abstract::The proportion of total limb length taken up by the individual skeletal elements (limb proportionality), varies widely between species. These diverse skeletal forms have evolved to allow for a range of limb uses and they first emerge as the embryo develops, to achieve the characteristic skeletal architecture of each s...
journal_title:Journal of anatomy
pub_type: 杂志文章,评审
doi:10.1111/joa.12171
更新日期:2014-06-01 00:00:00
abstract::The distribution of chondrocytes throughout the total thickness of articular cartilage from the femoral condyles of infants, children and adults has been studied using serial sections cut parallel as well as perpendicular to the articular surface. The thickness of the articular cartilage was estimated in fixed section...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1988-04-01 00:00:00
abstract::During development, muscle growth is usually finely adapted to meet functional demands in daily activities. However, how muscle geometry changes in typically developing children and how these changes are related to functional and mechanical properties is largely unknown. In rodents, longitudinal growth of the pennate ...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2011.01402.x
更新日期:2011-09-01 00:00:00
abstract::This paper reports on the development of a theoretical model to simulate the growth and repair of microdamage in bone. Unlike previous theories, which use simplified descriptions of damage, this approach models each individual microcrack explicitly, and also models the basic multicellular units (BMUs) that repair crac...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1046/j.1469-7580.2003.00194.x
更新日期:2003-08-01 00:00:00
abstract::One of the great ongoing debates in palaeo-anthropology is when, and how, hominids acquired habitual bipedal locomotion. The newly adopted bipedal gait and the ancestral quadrupedal gait are most often considered as very distinct, with each habitual locomotor mode showing corresponding anatomical adaptations. Bonobos ...
journal_title:Journal of anatomy
pub_type: 杂志文章,评审
doi:10.1111/j.0021-8782.2004.00292.x
更新日期:2004-05-01 00:00:00
abstract::A combination of stereology and physiology is used to estimate the morphometric diffusing capacity for oxygen of the normal human placenta at term. The morphometric diffusing capacity is found to be higher than published values determined by physiological methods. The most likely explanation for this discrepancy is th...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1984-12-01 00:00:00
abstract::Due to conflicting data from previous studies a new methodological approach to evaluate heel pad stiffness and soft tissue deformation has been developed. The purpose of this study was to compare heel pad (HP) stiffness in both limbs between males and females during a dynamic unloading and loading activity. Ten males ...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.13207
更新日期:2020-09-01 00:00:00
abstract::The objective of the current study was to determine the tissue distribution of cells derived from the area opaca in heterospecific quail-chick blastodermal chimeras. Quail-chick chimeras were constructed by transferring dissociated cells from the area opaca of the stage X-XII (EG&K) quail embryo into the subgerminal c...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2009.01168.x
更新日期:2010-01-01 00:00:00
abstract::The heart is the first functioning organ to develop during embryogenesis. The formation of the heart is a tightly regulated and complex process, and alterations to its development can result in congenital heart defects. Mutations in sarcomeric proteins, such as alpha myosin heavy chain and cardiac alpha actin, have no...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12486
更新日期:2016-09-01 00:00:00
abstract::The mean fibre areas of samples from m. semitendinosus, m. diaphragma and m. pectoralis transversus of thoroughbred horses and greyhounds have been compared with those in similar samples from other members of their species. Athletes (greyhounds and thoroughbreds) have larger fibres in the semitendinosus and diaphragm ...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1978-10-01 00:00:00
abstract::The vestibular system, located in the inner ear, plays a crucial role in balance and gaze stabilisation by sensing head movements. The interconnected tubes with membranous walls of the vestibular system are located in the skull bone (the 'membranous labyrinth'). Unfortunately, these membranes are very hard to visualis...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12885
更新日期:2018-12-01 00:00:00
abstract::The normal number and arrangement of motoneurons contributing fibres, via the median and radial nerves, to the forearm muscles of the rat were determined at different stages of postnatal development. Horseradish peroxidase was applied directly to the proximal cut ends of the nerves in 5, 10, 21 days old and adult rats...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1990-08-01 00:00:00
abstract::The onset and evolution of the meiotic prophase were assessed by histological and cytological techniques in fetal and neonatal ovaries obtained from day 13 postcoitum to day 11 postpartum in the golden hamster (Mesocricetus auratus). The histological technique based on the Feulgen stain and the cytological technique b...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1981-06-01 00:00:00
abstract::Trabecular bone microstructural parameters, including trabecular thickness, spacing, and number, have been reported to scale with animal size with negative allometry, whereas bone volume fraction is animal size-invariant in terrestrial mammals. As for the majority of scaling patterns described in animals, its underlyi...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12278
更新日期:2015-03-01 00:00:00
abstract::The development of pneumatisation in the postcranial skeleton has been investigated in a flock of Golden Comet pullets from hatching to 182 days posthatching. The timing of development of pneumatisation in the vertebral column, vertebral ribs, sternum and humerus has been demonstrated. No pneumatisation was encountere...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1984-08-01 00:00:00
abstract::The architecture of the fibres in the sciatic nerve of the dog has been analysed by following the degeneration of fibres resulting from division of the individual spinal nerves which contribute to the sciatic nerve. A pattern has been demonstrated which varies in part with the size of the contribution to the sciatic n...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1978-10-01 00:00:00
abstract::The extracellular matrix (ECM) of connective tissues enables linking to other tissues, and plays a key role in force transmission and tissue structure maintenance in tendons, ligaments, bone and muscle. ECM turnover is influenced by physical activity, and both collagen synthesis and metalloprotease activity increase w...
journal_title:Journal of anatomy
pub_type: 杂志文章,评审
doi:10.1111/j.1469-7580.2006.00549.x
更新日期:2006-04-01 00:00:00
abstract::The testicular capsule was studied histologically, morphometrically, ultrastructurally and immunohistochemically in the Japanese quail, domestic fowl, turkey and duck (all members of the Galloanserae). The testicular capsule was, relative to mammals, thin, being 81.5 +/- 13.7 microm in the quail, 91.7 +/- 6.2 microm i...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2007.00726.x
更新日期:2007-06-01 00:00:00