Abstract：
:Experimental evidence indicates that lymph nodes in humans undergo alterations during ageing. This is clinically important because of the crucial role of these organs in the immune system and their lymph reabsorption and drainage function. Although some age-related changes in lymph node histoarchitecture have been described, they are seldom taken into account in traditional depictions of lymph nodes. Recently introduced clinical procedures, such as intranodal vaccination or lymph node transplantation, have demonstrated the need for an accurate knowledge of these degenerative processes. In this study, superficial inguinal lymph nodes were obtained from 41 deceased patients between 17 and 98 years old. To minimize immunological influences, such as chronic diseases, specimens were only obtained from forensic pathology autopsies. An immunohistochemical analysis was carried out, on the basis of which lymph node degeneration was scored according to the numbers of lymphocytes and high endothelial venules, and degree of fibrosis and lipomatosis. We observed an age-dependent tendency towards the replacement of areas populated with diverse immune cells by connective tissue. Paradoxically, these changes were also detected in some of the nodes from younger age groups. In conclusion, lymph nodes can display degenerative changes that are mainly age-related and often diverge from the common description found in textbooks. These alterations should be taken into account when dealing with lymph nodes diagnostically and therapeutically in clinical practice.
journal_name
J Anatjournal_title
Journal of anatomyauthors
Hadamitzky C,Spohr H,Debertin AS,Guddat S,Tsokos M,Pabst Rdoi
10.1111/j.1469-7580.2010.01213.xsubject
Has Abstractpub_date
2010-05-01 00:00:00pages
556-62issue
5eissn
0021-8782issn
1469-7580pii
JOA1213journal_volume
216pub_type
杂志文章abstract：:Quantitative craniometrical traits have been successfully incorporated into population genetic methods to provide insight into human population structure. However, little is known about the degree of genetic and non-genetic influences on the phenotypic expression of functionally based traits. Many studies have assesse...
journal_title：Journal of anatomy
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journal_title：Journal of anatomy
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abstract：:Retrograde fluorescent transport of Fast Blue (FB) and Diamidino Yellow (DY) was used to study the localisation of neurons that innervate the palpebral conjunctiva and the superior tarsal muscle in the cynomolgous monkey. Labelled cell bodies of sensory neurons including a few double labelled cell bodies were found in...
journal_title：Journal of anatomy
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journal_title：Journal of anatomy
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journal_title：Journal of anatomy
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journal_title：Journal of anatomy
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doi：
更新日期：1978-05-01 00:00:00
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pub_type： 杂志文章
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journal_title：Journal of anatomy
pub_type： 杂志文章,评审
doi：10.1111/joa.12171
更新日期：2014-06-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1989-10-01 00:00:00
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journal_title：Journal of anatomy
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journal_title：Journal of anatomy
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doi：
更新日期：1984-03-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1996-04-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章,评审
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更新日期：2009-04-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
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journal_title：Journal of anatomy
pub_type： 杂志文章
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2008.01030.x
更新日期：2009-02-01 00:00:00
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journal_title：Journal of anatomy
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journal_title：Journal of anatomy
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journal_title：Journal of anatomy
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journal_title：Journal of anatomy
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doi：
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journal_title：Journal of anatomy
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更新日期：1994-10-01 00:00:00
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journal_title：Journal of anatomy
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journal_title：Journal of anatomy
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doi：
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journal_title：Journal of anatomy
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doi：
更新日期：1983-09-01 00:00:00
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journal_title：Journal of anatomy
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pub_type： 杂志文章,评审
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journal_title：Journal of anatomy
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更新日期：1987-02-01 00:00:00
