Abstract：
:Atrial and ventricular myocardium from young golden hamsters, 3-6 months of age, was examined under the transmission electron microscope, representative samples from each animal having been stained histochemically for acid phosphatase (AP) by a lead precipitation technique. Our observations indicated that AP positive primary lysosomes are produced at the sites of Golgi-endoplasmic reticulum-lysosome (GERL) complexes and the main pathway for lipofuscin production is by fusion of primary lysosomes with mitochondria in both atrial and ventricular myocytes. The mitochondria are then progressively degraded, their matrix becomes denser and there is an accompanying increase of AP activity. After reaching a peak level, AP activity declines until an AP negative terminal pigment body with a smooth outline is produced. Another pathway, but much less frequent at this age leads to the formation of larger bodies, irregular in outline and containing small globules. Their genesis entails the participation of autophagic vacuoles which engulf lipid droplets, mitochondria or amorphous debris. Like the main variety of lipofuscin body, they contain AP while digestion progresses but eventually become AP negative. A few lipofuscin granules are eliminated by being pinched off within fine cell protrusions and are subsequently engulfed by scavenger cells.
journal_name
J Anatjournal_title
Journal of anatomyauthors
Skepper JN,Navaratnam Vsubject
Has Abstractpub_date
1987-02-01 00:00:00pages
155-67eissn
0021-8782issn
1469-7580journal_volume
150pub_type
杂志文章abstract：:The distance of the neuromuscular gap was measured in a chicken smooth muscle, m. retractor phalli cranialis (MRPC). For the identification of active neuromuscular contacts, acetylcholinesterase (AChE) was stained according to Tago's modification of the Karnovsky and Roots' method. Thirty two out of 500 muscle cells w...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1990-06-01 00:00:00
abstract：:The posterior orbitofrontal cortex, anterior temporal sensory association areas and the amygdala have a key role in emotional processing and are robustly interconnected. By analogy with the pattern of connections in early processing sensory areas, anterior temporal sensory and polymodal association cortices send prima...
journal_title：Journal of anatomy
pub_type： 杂志文章,评审
doi：10.1111/j.1469-7580.2007.00777.x
更新日期：2007-08-01 00:00:00
abstract：:It is known that removal of one eye in the rat in early postnatal life results in an aberrant ipsilateral projection from the remaining eye. We have estimated the number of optic nerve fibres in 36 days old Black and White Hooded rats that had been unilaterally enucleated at birth. There was no significant difference ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1991-02-01 00:00:00
abstract：:The mammalian cochlea is a remarkable sensory organ, capable of perceiving sound over a range of 10(12) in pressure, and discriminating both infrasonic and ultrasonic frequencies in different species. The sensory hair cells of the mammalian cochlea are exquisitely sensitive, responding to atomic-level deflections at s...
journal_title：Journal of anatomy
pub_type： 杂志文章,评审
doi：10.1111/joa.12314
更新日期：2016-02-01 00:00:00
abstract：:Genetic mutation leads to anatomical variation only indirectly because many proteins involved in generating anatomical structures in embryos operate cooperatively within molecular networks. These include gene-regulatory or control networks (CNs) for timing, signaling and patterning together with the process networks (...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12205
更新日期：2014-08-01 00:00:00
abstract：:In stem-cell research a major difficulty is caused by the lack of distinctive features that allow the identification of human mesenchymal stem cells (hMSC). Until now, there has been no specific marker and the most common way to identify hMSC is by their characteristic stem-cell properties: self-replication and differ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2004.00252.x
更新日期：2004-02-01 00:00:00
abstract：:The anisotropic, inhomogeneous, multiply collagenous architecture of the annulus reflects the complex pattern of mainly tensile stresses developed in this region of the disc during normal function. Structural and mechanical responses of fully hydrated in-plane sections taken from within single lamellae of the outer an...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2005.00467.x
更新日期：2005-10-01 00:00:00
abstract：:Apoptosis is an essential physiological process in embryonic development. In the developing eye of vertebrates, three periods of developmental apoptosis can be distinguished: early, intermediate and later. Within the apoptosis pathway, caspases play a crucial role. It has also been shown that HSP110 may have a potenti...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2007.00719.x
更新日期：2007-05-01 00:00:00
abstract：:Congenitally corrected transposition of the great arteries (ccTGA) is a rare congenital malformation which associates discordant atrioventricular and ventriculo-arterial connections. Although frequently associated with a ventricular septal defect (VSD), its anatomy remains controversial. This could be due in hearts wi...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.13097
更新日期：2020-02-01 00:00:00
abstract：:Although it is generally assumed that herbivores have more voluminous body cavities due to larger digestive tracts required for the digestion of plant fiber, this concept has not been addressed quantitatively. We estimated the volume of the torso in 126 terrestrial tetrapods (synapsids including basal synapsids and ma...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12557
更新日期：2017-02-01 00:00:00
abstract：:The aim of this study was to design, develop and employ a method for the acquisition of a significant data base of thickness measurements. The integration of standard histological techniques (step serial sectioning), modern computer technology and a personally developed software package (specifically designed for thic...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1991-10-01 00:00:00
abstract：:The ultrastructure of the basal lamina of histologically normal human breast tissue was determined in 19 women undergoing operations for removal of a fibroadenoma or reduction mammoplasty. The day of the menstrual cycle was determined by hormone assay and direct questioning. Previously documented ultrastructural appea...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1988-02-01 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease with clinical, pathological and genetic overlap with frontotemporal dementia (FTD). No longer viewed as one disease with a single unified cause, ALS is now considered to be a clinicopathological syndrome resulting from a complex convergence of ...
journal_title：Journal of anatomy
pub_type： 杂志文章,评审
doi：10.1111/joa.12107
更新日期：2014-01-01 00:00:00
abstract：:At the time of blastocyst implantation the uterine spiral arteries have already undergone morphological changes in the absence of any extravillous trophoblast invasion. Only 2 weeks after implantation, extravillous trophoblast cells develop and come into first contact with decidual tissues. Invading through the decidu...
journal_title：Journal of anatomy
pub_type： 杂志文章,评审
doi：10.1111/j.1469-7580.2008.01036.x
更新日期：2009-07-01 00:00:00
abstract：:Facial size reduction and facial retraction are key features that distinguish modern humans from archaic Homo. In order to more fully understand the emergence of modern human craniofacial form, it is necessary to understand the underlying evolutionary basis for these defining characteristics. Although it is well estab...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2009.01162.x
更新日期：2010-01-01 00:00:00
abstract：:Motor control circuitry of the central nervous system must be flexible so that motor behaviours can be adapted to suit the varying demands of different states, developmental stages, and environments. Flexibility in motor control is largely provided by neuromodulatory systems which can adjust the output of motor circui...
journal_title：Journal of anatomy
pub_type： 杂志文章,评审
doi：10.1111/joa.12063
更新日期：2014-01-01 00:00:00
abstract：:How changes in anatomy affect joint biomechanics can be studied using musculoskeletal modelling, making it a valuable tool to explore joint function in healthy and pathological joints. However, gathering the anatomical, geometrical and physiological data necessary to create a model can be challenging. Very few integra...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12877
更新日期：2018-11-01 00:00:00
abstract：:The innervation of rat intervertebral disc and adjacent ligamentous tissue has been investigated using 2 antibodies, RT97 and anti-calcitonin gene-related peptide. Immunoreactivity to the peptide was found in many fibres throughout the long ligaments around the intervertebral discs and in the periosteum, especially as...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1992-02-01 00:00:00
abstract：:The anatomy of porcine bronchial circulation has not been fully described. The purpose of this study was to investigate the extrapulmonary topographic anatomy of bronchial arteries in pig. Ten pigs weighing 15-25 kg were studied. Between one and four bronchial arteries were found in each pig. The bronchoesophageal art...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2005.00455.x
更新日期：2005-10-01 00:00:00
abstract：:The structure of the gonad primordia is described in the embryos of three species of poeciliid fish. Prior to the sexualisation of the germ cells, a dimorphism exists based upon the gonadal somatic features. This serves as a basis for distinguishing between male and female specimens. Presumptive males are characterise...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1985-03-01 00:00:00
abstract：:The type and number of cell contacts between fibroblasts were studied in three structurally distinct varieties of periodontal connective tissue in the rat mandible (periodontal ligament of the incisor, enamel-related connective tissue of the incisor and periodontal ligament of the molar). Three types of cell contact w...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1981-08-01 00:00:00
abstract：:The entire head and neck of a wild adult male Mongolian gazelle (Procapra gutturosa) was dissected with special reference to its enlarged larynx. Two additional adult male specimens taken from the wild were analysed by computer tomography. The sternomandibularis, omohyoideus, thyrohyoideus and hyoepiglotticus muscles ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.2003.00232.x
更新日期：2003-11-01 00:00:00
abstract：:The straightforward anatomical organisation of the developing and mature rat spinal cord was used to determine and interpret the time of appearance and expression patterns of microtubule-associated proteins (MAP) 1b and 2. Immunoblots revealed the presence of MAP1b and 2 in the early embryonic rat spinal cord and conf...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1995-12-01 00:00:00
abstract：:Premature closure of the sagittal suture occurs as an isolated (nonsyndromic) birth defect or as a syndromic anomaly in combination with other congenital dysmorphologies. The genetic causes of sagittal nonsyndromic craniosynostosis (NSC) remain unknown. Although variation of the dysmorphic (scaphocephaly) skull shape ...
journal_title：Journal of anatomy
pub_type： 杂志文章,多中心研究
doi：10.1111/j.1469-7580.2010.01258.x
更新日期：2010-08-01 00:00:00
abstract：:The bioavailability of polystyrene particles (1 microns) labelled with FITC (3M Company, Düsseldorf) was tested in rats after enteral administration. Since macromolecules and particles are preferentially transported in the lymph, the number of particles was counted in the lymph of the thoracic duct over a 6 h period. ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1996-12-01 00:00:00
abstract：:A monoclonal antibody SBU-3 raised against an antigen expressed by the binucleate cells in the trophoblast of the sheep placentome crossreacts with an antigen expressed by binucleate cells in the placenta of the deer and the cow. This monoclonal antibody has been used to study the distribution of this subpopulation of...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1986-08-01 00:00:00
abstract：:We characterized the architecture, fiber type, titin isoform distribution, and collagen content of 27 portions of 22 muscles in the murine forelimb. The mouse forelimb was different from the human arm in that it had the extensor digitorum lateralis muscle and no brachioradialis muscle. Architecturally, the mouse forel...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2012.01559.x
更新日期：2012-11-01 00:00:00
abstract：:One of the most prominent features of the cranial component of the temporomandibular joint (TMJ) is the articular eminence (AE). This bar of bone is the primary surface upon which the condyle translates and rotates during movements of the mandible, and is therefore the primary point at which forces are transmitted fro...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2011.01424.x
更新日期：2011-11-01 00:00:00
abstract：:Abstract The skull and the face are directly related, and skeletal morphology influences the facial proportions, muscle structure, feature formation and hence detailed facial appearance. Each face is unique and we are each capable of perceiving very subtle differences between faces in order to carry out personal recog...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2008.00972.x
更新日期：2008-11-27 00:00:00
abstract：:Uptake and translocation of particulates across the mucosal barrier of the gastrointestinal (GI) tract is now generally recognised but the effect of pathophysiologically induced changes on this process is less well established. This study evaluated the effect of diabetes mellitus on GI absorption of particles, compari...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1996-12-01 00:00:00
