Where hearing starts: the development of the mammalian cochlea.

Abstract:

:The mammalian cochlea is a remarkable sensory organ, capable of perceiving sound over a range of 10(12) in pressure, and discriminating both infrasonic and ultrasonic frequencies in different species. The sensory hair cells of the mammalian cochlea are exquisitely sensitive, responding to atomic-level deflections at speeds on the order of tens of microseconds. The number and placement of hair cells are precisely determined during inner ear development, and a large number of developmental processes sculpt the shape, size and morphology of these cells along the length of the cochlear duct to make them optimally responsive to different sound frequencies. In this review, we briefly discuss the evolutionary origins of the mammalian cochlea, and then describe the successive developmental processes that lead to its induction, cell cycle exit, cellular patterning and the establishment of topologically distinct frequency responses along its length.

journal_name

J Anat

journal_title

Journal of anatomy

authors

Basch ML,Brown RM 2nd,Jen HI,Groves AK

doi

10.1111/joa.12314

subject

Has Abstract

pub_date

2016-02-01 00:00:00

pages

233-54

issue

2

eissn

0021-8782

issn

1469-7580

journal_volume

228

pub_type

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