Abstract：
:Schwann cells are excluded from the CNS during development by the glial limiting membrane, an area of astrocytic specialisation present at the nerve root transitional zone, and at blood vessels in the neuropil. This barrier, however, can be disrupted and, with the highly migratory nature of Schwann cells, can result in their invasion and myelination of the CNS in many pathological situations. In this paper we demonstrate that this occurs in a number of myelin mutants, including the myelin deficient (md) and taiep rats and the canine shaking (sh) pup. While it is still relatively uncommon in the rodent mutants, the sh pup shows extensive Schwann cell invasion along the neuraxis. This invasion involves the spinal cord, brain stem, and cerebellum and increases in amount and distribution with age. In situ hybridisation studies using a Pzero riboprobe suggest that the likely origin of these cells in the sh pup is the nerve roots, primarily the dorsal roots. Paradoxically, Schwann cell myelination of the CNS increases with time in the sh pup despite a marked, progressive gliosis involving the glia limitans and neuropil. Thus the mechanism by which these cells migrate into the CNS through the gliosed nerve root transitional zone or from vasa nervorum remains unknown. Extensive Schwann cell CNS myelination may have therapeutic significance in human myelin disease.
journal_name
J Anatjournal_title
Journal of anatomyauthors
Duncan ID,Hoffman RLdoi
10.1046/j.1469-7580.1997.19010035.xsubject
Has Abstractpub_date
1997-01-01 00:00:00pages
35-49eissn
0021-8782issn
1469-7580journal_volume
190 ( Pt 1)pub_type
杂志文章,评审abstract：:The fine structure of the intercellular junctions of the hen parathyroid gland was studied using freeze-fracture replicas and thin sections. In the conventional thin sections, desmosomes, intermediate junctions (maculae adherentes) and gap junctions were observed, and in the lanthanum-fixed sections, tight junctions (...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1982-09-01 00:00:00
abstract：:During long bone development the original cartilaginous model in mammals is replaced by bone, but at the long bone endings the avascular articular cartilage remains. Before the articular cartilage attains structural maturity it undergoes reorganization, and molecules such as vascular endothelial growth factor (VEGF) a...
journal_title：Journal of anatomy
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abstract：:Because the cornea is optimized for refraction, it relies on supporting tissues for moistening and nutrition and in particular for immune protection. Its main support tissue is the conjunctiva, in addition to the lacrimal gland, the latter which provides soluble mediators via the tear film. The cornea and conjunctiva ...
journal_title：Journal of anatomy
pub_type： 杂志文章,评审
doi：10.1111/j.1469-7580.2005.00394.x
更新日期：2005-03-01 00:00:00
abstract：:Vascular sympathetic neuroeffector associations have been examined in rat iris arterioles using serial section electron microscopy and reconstruction techniques. Examination of random sections showed that, of all profiles of varicosities (199) seen to lie closer than 4 microns to vascular smooth muscle cells, only a s...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.1998.19210045.x
更新日期：1998-01-01 00:00:00
abstract：:Dry dissected rat incisor ameloblasts studied in the scanning electron microscope show remarkable specializations of their lateral surfaces. Four or five cycles of a change from a surface with longitudinal gutterlike folds associated with large intercellular spaces, to one with microvilli and reduced intercellular spa...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1976-12-01 00:00:00
abstract：:Congenitally corrected transposition of the great arteries (ccTGA) is a rare congenital malformation which associates discordant atrioventricular and ventriculo-arterial connections. Although frequently associated with a ventricular septal defect (VSD), its anatomy remains controversial. This could be due in hearts wi...
journal_title：Journal of anatomy
pub_type： 杂志文章
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.1997.19130431.x
更新日期：1997-10-01 00:00:00
abstract：:We previously identified a pericellular matrix keratan sulphate/chondroitin sulphate proteoglycan present on the surface of human embryonal carcinoma stem cells, cells whose differentiation mimics early development. Antibodies reactive with various epitopes on this molecule define a cluster of differentiation markers ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.2002.00034.x
更新日期：2002-03-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
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更新日期：2020-09-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
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更新日期：2018-02-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
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更新日期：2012-12-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章,评审
doi：10.1046/j.1469-7580.2000.19740571.x
更新日期：2000-11-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1980-06-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1990-08-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
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更新日期：2015-11-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12590
更新日期：2017-05-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2012.01543.x
更新日期：2012-10-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2008.01015.x
更新日期：2009-01-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1980-12-01 00:00:00
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journal_title：Journal of anatomy
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doi：
更新日期：1986-12-01 00:00:00
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journal_title：Journal of anatomy
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更新日期：2015-12-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1991-02-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1994-10-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
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更新日期：2019-12-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1977-09-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
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更新日期：2021-01-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1991-06-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1978-05-01 00:00:00
