Abstract：
:Motor control circuitry of the central nervous system must be flexible so that motor behaviours can be adapted to suit the varying demands of different states, developmental stages, and environments. Flexibility in motor control is largely provided by neuromodulatory systems which can adjust the output of motor circuits by modulating the properties and connectivity of neurons within them. The spinal circuitry which controls locomotion is subject to a range of neuromodulatory influences, including some which are intrinsic to the spinal cord. One such intrinsic neuromodulatory system, for which a wealth of anatomical information has recently been combined with new physiological data, is the C bouton system. C boutons are large, cholinergic inputs to motor neurons which were first described over 40 years ago but whose source and function have until recently remained a mystery. In this review we discuss how the convergence of anatomical, molecular genetic and physiological data has recently led to significant advances in our understanding of this unique neuromodulatory system. We also highlight evidence that C boutons are involved in spinal cord injury and disease, revealing their potential as targets for novel therapeutic strategies.
journal_name
J Anatjournal_title
Journal of anatomyauthors
Witts EC,Zagoraiou L,Miles GBdoi
10.1111/joa.12063subject
Has Abstractpub_date
2014-01-01 00:00:00pages
52-60issue
1eissn
0021-8782issn
1469-7580journal_volume
224pub_type
杂志文章,评审abstract：:Previous quantitative descriptions of cellular ultrastructure have focused on spatial content (volume, surface area and number of organelles and membrane domains). It is possible to complement such descriptions by also quantifying spatial arrangements. Hitherto, applications of stereological methods for achieving this...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.1999.19420279.x
更新日期：1999-02-01 00:00:00
abstract：:The aims of the present study were to determine whether nerves that contain nitric oxide synthase (NOS), calcitonin gene-related peptide (CGRP) or substance P (SP) are present in the human vagina and, if so, to determine the pattern of innervation relative to that of other neurotransmitters, particularly vasoactive in...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1996-06-01 00:00:00
abstract：:Scales of snakes contain hard proteins (beta-keratins), now referred to as keratin-associated beta-proteins. In the present study we report the isolation, sequencing, and expression of a new group of these proteins from snake epidermis, designated cysteine-glycine-proline-rich proteins. One deduced protein from expres...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2009.01192.x
更新日期：2010-03-01 00:00:00
abstract：:The aortic plexus is a network of sympathetic nerves positioned along the infrarenal abdominal aorta. Recently, we characterized the aortic plexus and its ganglia (inferior mesenteric, left/right spermatic, and prehypogastric ganglion) in males; however, the literature minimally describes its anatomy in females. In th...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12436
更新日期：2016-05-01 00:00:00
abstract：:This study was carried out on 208 Nigerian bony palates in dried skulls and on 30 palates obtained from Nigerian cadavers. Out of 208 dried skulls examined, there was a unilateral spine in 21.1% of cases, a bilateral spine in 36.5% and a bony canal in 5.7%. Of the dissected palates 30% revealed the presence of an osse...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1988-02-01 00:00:00
abstract：:It is unknown whether loading of the lower limbs through additional storage of fat mass as evident in obesity would promote muscular adaptations similar to those seen with resistance exercise. It is also unclear whether ageing modulates any such adjustments. This study aimed to examine the relationships between adipos...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12248
更新日期：2014-12-01 00:00:00
abstract：:The development of pneumatisation in the postcranial skeleton has been investigated in a flock of Golden Comet pullets from hatching to 182 days posthatching. The timing of development of pneumatisation in the vertebral column, vertebral ribs, sternum and humerus has been demonstrated. No pneumatisation was encountere...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1984-08-01 00:00:00
abstract：:Facial expressions are a critical mode of non-vocal communication for many mammals, particularly non-human primates. Although chimpanzees (Pan troglodytes) have an elaborate repertoire of facial signals, little is known about the facial expression (i.e. mimetic) musculature underlying these movements, especially when ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2006.00523.x
更新日期：2006-02-01 00:00:00
abstract：:The extent of neuronal labelling with horseradish peroxidase (HRP) was examined in rat trigeminal motor neurons at various stages of acrylamide intoxication, following HRP uptake by motor nerve endings in the anterior digastric muscle. After 7 days of acrylamide (5 daily injections of 30 mg acrylamide/kg body weight),...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1983-10-01 00:00:00
abstract：:Bundles of collagen fibrils, elastic fibres and fibroblasts are organized into a network that lies in the plane of a large portion of the bat wing. By ultrastructural (TEM and SEM) and biochemical analyses it was found that individual bundles of the net are similar to elastic ligaments. Although elastic fibres predomi...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1978-05-01 00:00:00
abstract：:Pulmonary alveolar septa are thought to contain at least two types of fibroblasts that are termed myofibroblasts and lipofibroblasts based on their morphological characteristics. Lipofibroblasts possess cytoplasmic lipid inclusions (lipid bodies or droplets) and are involved in several important functions, such as sur...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12677
更新日期：2017-12-01 00:00:00
abstract：:Development of the neural crest involves a remarkable feat of coordinated cell migration in which cells detach from the neural tube, take varying routes of migration through the embryonic tissues and then differentiate at the end of their journey to participate in the formation of a number of organ systems. In general...
journal_title：Journal of anatomy
pub_type： 杂志文章,评审
doi：10.1046/j.1469-7580.1997.19140507.x
更新日期：1997-11-01 00:00:00
abstract：:This review describes the progress made in preparing Cochrane systematic reviews of randomized controlled trials for Guillain-Barré syndrome (GBS), chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), multifocal motor neuropathy (MMN) and the demyelinating neuropathies associated with paraproteins. The di...
journal_title：Journal of anatomy
pub_type： 杂志文章,评审
doi：10.1046/j.1469-7580.2002.00041.x
更新日期：2002-04-01 00:00:00
abstract：:During ageing, a progressive loss of skeletal muscle mass and a decrease in muscle strength and endurance take place, in the condition termed sarcopenia. The mechanisms of sarcopenia are complex and still unclear; however, it is known that muscle atrophy is associated with a decline in the number and/or efficiency of ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12429
更新日期：2016-05-01 00:00:00
abstract：:The production of echolocation calls in bats along with forces produced by contraction of thoracic musculature used in flight presumably puts relatively high mechanical loads on the lower respiratory tract (LRT). Thus, there are likely adaptations to prevent collapse or distortion of the bronchial tree and trachea dur...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12575
更新日期：2017-04-01 00:00:00
abstract：:The morphometric and quantitative changes associated with the differentiation of amoeboid microglia into ramified microglial cells in the corpus callosum of rats between 21 d postconception (E21) and 15 d postnatally are described. Using lectin labelling, 5 morphological types of labelled cells (R, SP, KLP, TLP, AP) b...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1992-12-01 00:00:00
abstract：:One of the most prominent features of the cranial component of the temporomandibular joint (TMJ) is the articular eminence (AE). This bar of bone is the primary surface upon which the condyle translates and rotates during movements of the mandible, and is therefore the primary point at which forces are transmitted fro...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2011.01424.x
更新日期：2011-11-01 00:00:00
abstract：:The aim of this study is to quantify and statistically model the age-related decline in the fibrous connective tissue interface of the anterior fontanelle in modern Australian infants, using three-dimensional, semi-automated computed-assisted design protocols. Non-linear regression with variance models, using power fu...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.13200
更新日期：2020-08-01 00:00:00
abstract：:This study demonstrates that the earlier growth spurt in vertebral height in females and the greater growth in vertebral transverse diameter in males, both give rise to sexual dimorphism in vertebral shape, female vertebral bodies being significantly more slender than male vertebral bodies from the age of 8 years onwa...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1984-03-01 00:00:00
abstract：:Knowledge of the pattern of human craniofacial development in the fetal period is important for understanding the mechanisms underlying the emergence of variations in human craniofacial morphology. However, the precise character of the prenatal ontogenetic development of the human cranium has yet to be fully establish...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2008.00884.x
更新日期：2008-05-01 00:00:00
abstract：:The anatomy of the hypothalamus includes many nuclei and a complex network of neurocircuits. In this context, some hypothalamic nuclei reside closer to the blood-brain barrier, allowing communication with the peripheral organs through some molecules, such as leptin. Leptin is considered the main adipokine for energy h...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.13342
更新日期：2020-10-22 00:00:00
abstract：:The T-tubule system in cardiac muscle cells has been investigated with the electron microscope in 10 adult rats after infiltration with horseradish peroxidase. All cardiac muscle cells possess a T-system, but its complexity varies according to the region of the heart. It is most extensive in the general ventricular my...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1978-09-01 00:00:00
abstract：:Developing Xenopus embryos treated during gastrulation with 22 micrograms/l of salmar calcitonin in the ambient water develop into larvae exhibiting a decrease in interocular distance. In view of the hypocalcaemic properties of calcitonin and the importance of calcium ions in cell aggregation, this phenomenon has been...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:Proper assessment of outcome in clinical trials of neural transplantation requires both biochemical and imaging indices of graft survival, and behavioural and physiological indices of graft function. For transplantation in Huntington's disease, a variety of ligands that are selective for striatal degeneration and graf...
journal_title：Journal of anatomy
pub_type： 杂志文章,评审
doi：10.1046/j.1469-7580.2000.19640597.x
更新日期：2000-05-01 00:00:00
abstract：:Growth affects the performance of structure, so the pattern of growth must influence the role of a structure and an organism. Because animal performance is linked to morphological specialization, ontogenetic change in size may influence an organism's biological role. High bite force generation is presumably selected f...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12342
更新日期：2015-09-01 00:00:00
abstract：:The mean fibre areas of samples from m. semitendinosus, m. diaphragma and m. pectoralis transversus of thoroughbred horses and greyhounds have been compared with those in similar samples from other members of their species. Athletes (greyhounds and thoroughbreds) have larger fibres in the semitendinosus and diaphragm ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1978-10-01 00:00:00
abstract：:The developing cortical surfaces of long bones are sculpted and modeled by periosteal osteoclasts and osteoblasts. These surfaces also receive the insertions of tendons and ligaments, and these insertion sites too are modeled to form the root systems that anchor them into the cortical bone. The regulatory molecules th...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12145
更新日期：2014-04-01 00:00:00
abstract：:Blind mole-rats (Spalax ehrenbergi) are fossorial solitary rodents that present striking morphological, physiological and behavioural adaptations to the subterranean environment in which they live. Previous studies have shown that mole-rats are specialised in tooth-digging. The rapid eruption-rate of their incisors ha...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.2001.19950591.x
更新日期：2001-11-01 00:00:00
abstract：:Pulmonary complications are frequently observed after transthoracic oesophagectomy. These complications may be reduced by sparing the vagus nerve branches to the lung. However, current descriptions of the regional anatomy are insufficient. Therefore, we aimed to provide a highly detailed description of the course of t...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12366
更新日期：2015-10-01 00:00:00
abstract：:The proposal that the cytoplasmic granules of glomerular peripolar cells (PPCs) of the adult sheep and lamb contain a kallikrein-like substance has been re-examined. After extensive characterisation and purification of anti-kallikrein antibodies, it was concluded that PPCs do not contain immunohistochemically detectab...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1989-02-01 00:00:00
