Abstract:
:Uptake and translocation of particulates across the mucosal barrier of the gastrointestinal (GI) tract is now generally recognised but the effect of pathophysiologically induced changes on this process is less well established. This study evaluated the effect of diabetes mellitus on GI absorption of particles, comparing particle localisation and particle loading in different microanatomical sites of the primary organ (small intestine) and possible particle translocation pathways to selected secondary organs (mesenteric lymph nodes, liver, spleen) in normal and streptozotocin-induced diabetic animals. Fluorescent polystyrene latex particles (approximately 2 microns diameter) were fed orally to young adult Sprague-Dawley rats and quantitative bulk tissue and morphological techniques used to chart particle transit across the small intestine to secondary organs 0.5 h postadministration. In the normal animal, epifluorescence and confocal laser scanning microscopy provided confirmatory evidence for particle absorption within the primary organ and transport to other sites in the body. By contrast, in the diabetic animal, particle translocation and peripheral distribution were reduced with approximately 30% decrease in particle loading in the epithelial/nonepithelial tissue compartments. This could be a consequence of gastric retention and altered intestinal motility and permeability which are known to be associated with diabetes.
journal_name
J Anatjournal_title
Journal of anatomyauthors
McMinn LH,Hodges GM,Carr KEsubject
Has Abstractpub_date
1996-12-01 00:00:00pages
553-9eissn
0021-8782issn
1469-7580journal_volume
189 ( Pt 3)pub_type
杂志文章abstract::The process of anatomical ductal obliteration appears to be gradual and to involve proliferation of intima and media (mainly the latter) producing mounds, mucoid-filled spaces and fragmentation of the internal elastic membrane. Dissociation of the inner media may also be involved. The persistent ductus can be recogniz...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1979-06-01 00:00:00
abstract::The form and position of the developing atrioventricular bundle and its branches has been studied in the hearts of domestic fowl embryos operated upon to induce delayed closure of the interventricular foramen. The operation was performed at 3 days of incubation when the outflow tract of the tubular heart was temporari...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1982-03-01 00:00:00
abstract::The elbow joint nerve, a small branch of the musculocutaneous nerve in the cat, was investigated with low power transmission electron microscopy. By taking a series of overlapping photographs a montage was constructed of the cross section appearance of the complete nerve. Thus, a complete count of the number and sizes...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1980-08-01 00:00:00
abstract::Fixed and unfixed human tendons originating from cadavers and postoperation specimens were examined using inclined parallel beams of light in a reflecting mode. Along the tendon, numerous planes, constantly inclined to the axis, were observed edge-on at the surface and within the interior. Their angle of inclination, ...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1995-06-01 00:00:00
abstract::Decline of tactile sensation associated with ageing depends on modifications in skin and both central and peripheral nervous systems. At present, age-related changes in the periphery of the somatosensory system, particularly concerning the effects on mechanoreceptors, remain unknown. Here we used immunohistochemistry ...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12983
更新日期:2019-06-01 00:00:00
abstract::The olfactory bulb of adult specimens of Carassius auratus was subjected to an autoradiographic study using [3H]thymidine. Adult specimens of Carassius auratus, Barbus meridionalis, Cyprinus carpio and Salmo gairdneri were also studied using light and electron microscopy. Cells were found undergoing mitotic division w...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1989-04-01 00:00:00
abstract::The sacroiliac joint (SIJ) is a well-known source of low back and pelvic pain, of increasing interest for both conservative and surgical treatment. Alterations in the kinematics of the pelvis have been hypothesized as a major cause of SIJ-related pain. However, definitions of both the range and the extent of physiolog...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12924
更新日期:2019-03-01 00:00:00
abstract::Crocodylians occupy a key phylogenetic position for investigations of archosaur locomotor evolution. Compared to the well-studied hindlimb, relatively little is known about the skeletal movements and mechanics of the forelimb. In this study, we employed manual markerless XROMM (X-ray Reconstruction Of Moving Morpholog...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12102
更新日期:2013-11-01 00:00:00
abstract::The examination of endocranial data of archosauriforms has led to advances on the evolution of body size, nerve pathways, and sensory abilities. However, much of that research has focused on bird-line archosaurs, resulting in a skewed view of Archosauria. Phytosauria, a hypothesized sister taxon to or early-branching ...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12668
更新日期:2017-11-01 00:00:00
abstract::Literature on the development of the human vagina is abundant; however, contributions concerning the prenatal development of the entire utero-vaginal anlagen (UVA) are rare or carried out in rodents. The primary epithelial characteristics in the adult vagina and uterus are determined during prenatal development and de...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12029
更新日期:2013-04-01 00:00:00
abstract::The vestibular system, located in the inner ear, plays a crucial role in balance and gaze stabilisation by sensing head movements. The interconnected tubes with membranous walls of the vestibular system are located in the skull bone (the 'membranous labyrinth'). Unfortunately, these membranes are very hard to visualis...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12885
更新日期:2018-12-01 00:00:00
abstract::The morphology of the epididymal duct and, in particular, the epididymal microvasculature was examined at the light microscope level in young sexually-mature rats (3-5 months) and aged rats (18 months) to investigate the structural changes that may occur within the organ as a result of ageing, and which may predispose...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00
abstract::Seminiferous tubules develop from sex cords, which are embryonic structures with simple C-shaped arches. Histologically, the epithelium of adult mouse seminiferous tubules has been divided into 12 stages based on the associations of spermatogenic cells in four cycles of spermatogenesis. However, the gross characterist...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12375
更新日期:2015-11-01 00:00:00
abstract::This study set out to determine the pattern of development and distribution of the interstitial cells of Cajal (ICC) in the intestinal tract of the equine fetus and neonate. Intestinal tissue samples from 12 naturally aborted equine fetuses and three euthanized neonates were collected and fixed in formalin prior to ap...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.0021-8782.2004.00315.x
更新日期:2004-07-01 00:00:00
abstract::A study of the attachments of the musculotendinous fibres of the lumbar erector spinae muscle shows that it is made of two parts: a superficial or costal part, and a deep or vertebral part. The superficial part arises by small fleshy slips from the posterior (superficial) surface as well as the rostral and lateral mar...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1986-02-01 00:00:00
abstract::The pituitary of roach, Rutilus rutilus (L.), is pear-shaped and situated in the sella turcica. It is characterised by a large pars nervosa, which penetrates deep into the other regions, splitting the proximal pars distalis. Spatial localisation of nerve fibre types and glandular cell types occurs. Using a variety of ...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1980-06-01 00:00:00
abstract::Vascular sympathetic neuroeffector associations have been examined in rat iris arterioles using serial section electron microscopy and reconstruction techniques. Examination of random sections showed that, of all profiles of varicosities (199) seen to lie closer than 4 microns to vascular smooth muscle cells, only a s...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1046/j.1469-7580.1998.19210045.x
更新日期:1998-01-01 00:00:00
abstract::Pulmonary complications are frequently observed after transthoracic oesophagectomy. These complications may be reduced by sparing the vagus nerve branches to the lung. However, current descriptions of the regional anatomy are insufficient. Therefore, we aimed to provide a highly detailed description of the course of t...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12366
更新日期:2015-10-01 00:00:00
abstract::Mucins are high molecular weight glycoproteins which constitute the major component of the mucus layer and are produce by many epithelial tissues in vertebrates. Osteopontin (OPN) is an adhesive phosphorylated glycoprotein that is expressed by a broad range of tissues and cells. Although gastric mucins MUC1, MUC5AC, M...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2010.01243.x
更新日期:2010-07-01 00:00:00
abstract::Blind mole-rats (Spalax ehrenbergi) are fossorial solitary rodents that present striking morphological, physiological and behavioural adaptations to the subterranean environment in which they live. Previous studies have shown that mole-rats are specialised in tooth-digging. The rapid eruption-rate of their incisors ha...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1046/j.1469-7580.2001.19950591.x
更新日期:2001-11-01 00:00:00
abstract::This study addresses the effects of increased mechanical load on the vertebral bone of post-smolt Atlantic salmon by forcing them to swim at controlled speeds. The fish swam continuously in four circular tanks for 9 weeks, two groups at 0.47 body lengths (bl) × s(-1) (non-exercised group) and two groups at 2 bl × s(-1...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2011.01399.x
更新日期:2011-10-01 00:00:00
abstract::An immuno-epifluorescence microscopic study of first trimester human chorionic villi has revealed different patterns of distribution for intermediate filament proteins. Keratin staining was restricted to the trophoblastic epithelium. The protein was shown to be concentrated into desmosome-containing apical and basal c...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1990-04-01 00:00:00
abstract::The heart is the first functioning organ to develop during embryogenesis. The formation of the heart is a tightly regulated and complex process, and alterations to its development can result in congenital heart defects. Mutations in sarcomeric proteins, such as alpha myosin heavy chain and cardiac alpha actin, have no...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12486
更新日期:2016-09-01 00:00:00
abstract::The distribution of enteroendocrine cells showing immunoreactivities to four peptides and one amine was examined in the gastric mucosa of the opossum during postnatal development using specific immunocytochemical methods. Gastrin-, BPP-, glucagon-, somatostatin- and 5-HT-immunoreactive cells were identified in the gas...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1986-10-01 00:00:00
abstract::The morphometric and quantitative changes associated with the differentiation of amoeboid microglia into ramified microglial cells in the corpus callosum of rats between 21 d postconception (E21) and 15 d postnatally are described. Using lectin labelling, 5 morphological types of labelled cells (R, SP, KLP, TLP, AP) b...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1992-12-01 00:00:00
abstract::In recent years, there has been increasing demand for personalized anatomy modelling for medical and industrial applications, such as ergonomics device development, clinical radiological exposure simulation, biomechanics analysis, and 3D animation character design. In this study, we constructed deformable torso phanto...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12815
更新日期:2018-07-01 00:00:00
abstract::At the time of blastocyst implantation the uterine spiral arteries have already undergone morphological changes in the absence of any extravillous trophoblast invasion. Only 2 weeks after implantation, extravillous trophoblast cells develop and come into first contact with decidual tissues. Invading through the decidu...
journal_title:Journal of anatomy
pub_type: 杂志文章,评审
doi:10.1111/j.1469-7580.2008.01036.x
更新日期:2009-07-01 00:00:00
abstract::Chromaffin cells were observed singly or in clusters in the heart and sympathetic cord of 2 genera of dipnoan fish, Protopterus and Lepidosiren. They were invariably found in close association with the autonomic sympathetic nervous system and at sites where chromaffin cells or their precursors are situated in mammals ...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1993-10-01 00:00:00
abstract::The urethra is the main place of entry for sexually transmitted pathogens. However, there is little literature on the morphology of the urogenital system, principally the urethra and ducts of the sex accessory glands. The Mongolian gerbil is an insectivorous, herbivorous and monogamous rodent with nocturnal habits; it...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1046/j.1469-7580.2003.00181.x
更新日期:2003-05-01 00:00:00
abstract::Knowledge of the pattern of human craniofacial development in the fetal period is important for understanding the mechanisms underlying the emergence of variations in human craniofacial morphology. However, the precise character of the prenatal ontogenetic development of the human cranium has yet to be fully establish...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2008.00884.x
更新日期:2008-05-01 00:00:00