Abstract:
:At the time of blastocyst implantation the uterine spiral arteries have already undergone morphological changes in the absence of any extravillous trophoblast invasion. Only 2 weeks after implantation, extravillous trophoblast cells develop and come into first contact with decidual tissues. Invading through the decidual interstitium, extravillous trophoblasts potentially reach and transform spiral arteries into uteroplacental arteries. Spiral arterial erosion starts at about mid-first trimester, whereas flow of maternal blood into the intervillous space is continuously established only at the beginning of the second trimester. One key regulator of the number of extravillous trophoblasts is oxygen. The steep gradient in oxygen concentration within the first trimester placenta is diminished with the onset of maternal blood flow. This gradient is used by the trophoblast to generate a large number of invasive cells to adapt the arterial vasculature in the placental bed to the growing needs of the fetus. Changes in oxygen concentrations or other factors leading to alterations in the rates of proliferation and/or apoptosis of extravillous trophoblast clearly impact on the remodelling of the vessels. The respective consequences of a failure in trophoblast invasion are growth restrictions of the baby and perhaps other pregnancy complications.
journal_name
J Anatjournal_title
Journal of anatomyauthors
Huppertz B,Gauster M,Orendi K,König J,Moser Gdoi
10.1111/j.1469-7580.2008.01036.xsubject
Has Abstractpub_date
2009-07-01 00:00:00pages
14-20issue
1eissn
0021-8782issn
1469-7580pii
JOA1036journal_volume
215pub_type
杂志文章,评审abstract::The number of neurons and glia in the mouse abducens nerve nucleus was estimated at 6, 25, 28 and 31 months of age. There was no significant variation in either the number of neurons (mean 118) or glia (mean 168) or in the glia to neuron ratio (mean 1.42) with age. Mean neuronal and glial nuclear diameters also remain...
journal_title:Journal of anatomy
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journal_title:Journal of anatomy
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journal_title:Journal of anatomy
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journal_title:Journal of anatomy
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journal_title:Journal of anatomy
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journal_title:Journal of anatomy
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journal_title:Journal of anatomy
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journal_title:Journal of anatomy
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journal_title:Journal of anatomy
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journal_title:Journal of anatomy
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