Abstract：
:The proportion of total limb length taken up by the individual skeletal elements (limb proportionality), varies widely between species. These diverse skeletal forms have evolved to allow for a range of limb uses and they first emerge as the embryo develops, to achieve the characteristic skeletal architecture of each species. During this time, the developing skeleton experiences mechanical loading as a result of embryonic muscle contraction. The possibility that adaptation to such mechanical input may allow embryos to coordinate the appearance of skeletal design with their expanding range of movements has so far received little attention. This is surprising, given the critical role exerted by embryo movement in normal skeletal development; stage-specific in ovo immobilisation of embryonic chicks results in joint contractures and a reduction in longitudinal bone growth in the limbs. Epigenetic mechanisms allow for selective activation of genes in response to environmental signals, resulting in the production of phenotypic complexity in morphogenesis; mechanical loading of bone during movement appears to be one such signal. It may be that 'mechanosensitive' genes under regulation of mechanical input adjust proportionality along the bone's proximo-distal axis, introducing a level of phenotypic plasticity. If this hypothesis is upheld, species with more elongated distal limb elements will have a greater dependence on mechanical input for the differences in their growth, and mechanosensitive bone growth in the embryo may have evolved as an additional source of phenotypic diversity during skeletal development.
journal_name
J Anatjournal_title
Journal of anatomyauthors
Pollard AS,McGonnell IM,Pitsillides AAdoi
10.1111/joa.12171subject
Has Abstractpub_date
2014-06-01 00:00:00pages
615-23issue
6eissn
0021-8782issn
1469-7580journal_volume
224pub_type
杂志文章,评审abstract：:The ultrastructure of the developing fetal lamb myocardium was studied in a series of animals spanning 29 days of gestation to term, and compared with newborn and adult animals. All major ultrastructural features which characterise the adult myocyte were found in early fetal life, although with considerably different ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1983-12-01 00:00:00
abstract：:Peripheral sensory and autonomic neurons are known to possess insulin receptors. These have been considered to be of the peripheral type, i.e. similar to those of hepatic and fat cells rather than of the brain type which show dual specificity for both insulin and insulin-like growth factor (IGF-1). We have examined th...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.1997.19130431.x
更新日期：1997-10-01 00:00:00
abstract：:The density and distribution of nerve fibres immunoreactive to antisera for PGP 9.5 (general neuronal marker), calcitonin gene related peptide (CGRP) and substance P (SP) (markers for sensory neurons), as well as neuropeptide Y (NPY), vasoactive intestinal peptide (VIP) and tyrosine hydroxylase (TH) (markers for auton...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.1997.19120245.x
更新日期：1997-08-01 00:00:00
abstract：:The penile bone and anterior process were made anorganic for scanning electron microscopy. The mature bone has a basal bulb and a long, cylindrical shaft bevelled at its tip to fit under a matching surface on the anterior process, giving rise to a bevelled 'suture'. A rough, resting, Sharpey-fibre bone surface covers ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1977-12-01 00:00:00
abstract：:The extent of neuronal labelling with horseradish peroxidase (HRP) was examined in rat trigeminal motor neurons at various stages of acrylamide intoxication, following HRP uptake by motor nerve endings in the anterior digastric muscle. After 7 days of acrylamide (5 daily injections of 30 mg acrylamide/kg body weight),...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1983-10-01 00:00:00
abstract：:This review begins by setting out the context and the scope of human evolution. Several classes of evidence, morphological, molecular, and genetic, support a particularly close relationship between modern humans and the species within the genus Pan, the chimpanzee. Thus human evolution is the study of the lineage, or ...
journal_title：Journal of anatomy
pub_type： 杂志文章,评审
doi：10.1046/j.1469-7580.2000.19710019.x
更新日期：2000-07-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 临床试验,杂志文章
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更新日期：2018-10-01 00:00:00
abstract：:Morphometric analysis of the kidney of the camel was carried out on gross slices and histological sections using standard morphometric methods. The renal cortex occupied about 50% by volume of the kidney, and the ratio of the thickness of the medulla to that of the cortex was about 4:1. The relative thickness of the m...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1979-08-01 00:00:00
abstract：:The primary aim of this study is to broadly evaluate the relationship between cursoriality (i.e. anatomical and physiological specialization for running) and limb bone morphology in lagomorphs. Relative to most previous studies of cursoriality, our focus on a size-restricted, taxonomically narrow group of mammals perm...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12220
更新日期：2014-10-01 00:00:00
abstract：:The distance of the neuromuscular gap was measured in a chicken smooth muscle, m. retractor phalli cranialis (MRPC). For the identification of active neuromuscular contacts, acetylcholinesterase (AChE) was stained according to Tago's modification of the Karnovsky and Roots' method. Thirty two out of 500 muscle cells w...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1990-06-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12575
更新日期：2017-04-01 00:00:00
abstract：:The T-tubule system in cardiac muscle cells has been investigated with the electron microscope in 10 adult rats after infiltration with horseradish peroxidase. All cardiac muscle cells possess a T-system, but its complexity varies according to the region of the heart. It is most extensive in the general ventricular my...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1978-09-01 00:00:00
abstract：:Excisional wounds were inflicted on the palatal mucoperiosteum of beagle pups at intervals from 3 to 31 days before the animals were killed, when the animals were perfused and the tissue examined by electron, microscopy. Fibroblasts with the morphological characteristics of myofibroblasts, including bundles of intrace...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1980-05-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1980-10-01 00:00:00
abstract：:We studied the cerebellar connections to the reticular nucleus thalamus (RNT) by means of retrograde axonal transport of horseradish peroxidase (HRP) in the rat. Specific HRP pressure injections to the rostral RNT (1.6-1.8 mm caudal to bregma) resulted in retrograde labelling of neurones in the cerebellar nuclei. The ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.2002.00119.x
更新日期：2002-12-01 00:00:00
abstract：:The structure of the gonad primordia is described in the embryos of three species of poeciliid fish. Prior to the sexualisation of the germ cells, a dimorphism exists based upon the gonadal somatic features. This serves as a basis for distinguishing between male and female specimens. Presumptive males are characterise...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1985-03-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2008.00972.x
更新日期：2008-11-27 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1980-10-01 00:00:00
abstract：:Langerhans cells of the epidermis of 6-month-old white crossbred farm pigs were identified by electron microscopy. Ultrastructurally they were similar to those described in other mammals. They were present in basal and suprabasal layers and were characterised by a lobulated nucleus and an electrolucent cytoplasm with ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1991-12-01 00:00:00
abstract：:The meaning of the term 'abdomen' has become increasingly ambiguous, as it has to satisfy the contemporary requirements of natural language discourse, literature, gross and radiological anatomy and its role in ontologies supporting electronic records and data modelling. It is critical that there is an agreed understan...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.13384
更新日期：2021-01-08 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.13269
更新日期：2020-12-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章,评审
doi：10.1111/j.1469-7580.2006.00624.x
更新日期：2006-10-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
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更新日期：2012-12-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2008.01015.x
更新日期：2009-01-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.2000.19610071.x
更新日期：2000-01-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1986-10-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.0021-8782.2004.00315.x
更新日期：2004-07-01 00:00:00
abstract：:The bronchial tree was investigated in 37 pairs of lungs of adult dogs using dissection and corrosion techniques. The external morphology of the lungs and their lobes has been described. The right lung was divided by deep fissures into four lobes, the apical, the middle, the diaphragmatic and the intermediate. The lef...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1980-12-01 00:00:00
abstract：:The proximal pelvic limb musculature of the Eastern Grey Kangaroo, Macropus giganteus (Zimm) is described with nine illustrations. The text is based on dissections of 44 Grey Kangaroos ranging in empty body weight from 791 g to 58 kg. ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1976-04-01 00:00:00
