Abstract:
:Pancreatic duct glands (PDGs) are tubule-alveolar glands associated with the pancreatic duct system and can be considered the anatomical counterpart of peribiliary glands (PBGs) found within the biliary tree. Recently, we demonstrated that endodermal precursor niches exist fetally and postnatally and are composed functionally of stem cells and progenitors within PBGs and of committed progenitors within PDGs. Here we have characterized more extensively the anatomy of human PDGs as novel niches containing cells with multiple phenotypes of committed progenitors. Human pancreata (n = 15) were obtained from cadaveric adult donors. Specimens were processed for histology, immunohistochemistry and immunofluorescence. PDGs were found in the walls of larger pancreatic ducts (diameters > 300 μm) and constituted nearly 4% of the duct wall area. All of the cells identified were negative for nuclear expression of Oct4, a pluripotency gene, and so are presumably committed progenitors and not stem cells. In the main pancreatic duct and in large interlobular ducts, Sox9(+) cells represented 5-30% of the cells within PDGs and were located primarily at the bottom of PDGs, whereas rare and scattered Sox9(+) cells were present within the surface epithelium. The expression of PCNA, a marker of cell proliferation, paralleled the distribution of Sox9 expression. Sox9(+) PDG cells proved to be Pdx1(+) /Ngn3(+/-) /Oct4A(-) . Nearly 10% of PDG cells were positive for insulin or glucagon. Intercalated ducts contained Sox9(+) /Pdx1(+) /Ngn3(+) cells, a phenotype that is presumptive of committed endocrine progenitors. Some intercalated ducts appeared in continuity with clusters of insulin-positive cells organized in small pancreatic islet-like structures. In summary, PDGs represent niches of a population of Sox9(+) cells exhibiting a pattern of phenotypic traits implicating a radial axis of maturation from the bottoms of the PDGs to the surface of pancreatic ducts. Our results complete the anatomical background that links biliary and pancreatic tracts and could have important implications for the common patho-physiology of biliary tract and pancreas.
journal_name
J Anatjournal_title
Journal of anatomyauthors
Carpino G,Renzi A,Cardinale V,Franchitto A,Onori P,Overi D,Rossi M,Berloco PB,Alvaro D,Reid LM,Gaudio Edoi
10.1111/joa.12418subject
Has Abstractpub_date
2016-03-01 00:00:00pages
474-86issue
3eissn
0021-8782issn
1469-7580journal_volume
228pub_type
杂志文章abstract::The anatomy of porcine bronchial circulation has not been fully described. The purpose of this study was to investigate the extrapulmonary topographic anatomy of bronchial arteries in pig. Ten pigs weighing 15-25 kg were studied. Between one and four bronchial arteries were found in each pig. The bronchoesophageal art...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2005.00455.x
更新日期:2005-10-01 00:00:00
abstract::Normal human kidneys were examined for the presence of granular peripolar cells. The prominent feature of the human peripolar cell was the presence of numerous cytoplasmic membrane-bound granules, which had the appearance of secretory granules. Most of the granules had a homogeneous matrix with no crystalline substruc...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1986-06-01 00:00:00
abstract::In recent years, there has been increasing demand for personalized anatomy modelling for medical and industrial applications, such as ergonomics device development, clinical radiological exposure simulation, biomechanics analysis, and 3D animation character design. In this study, we constructed deformable torso phanto...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12815
更新日期:2018-07-01 00:00:00
abstract::The blood-brain barrier (BBB) is formed by brain endothelial cells lining the cerebral microvasculature, and is an important mechanism for protecting the brain from fluctuations in plasma composition, and from circulating agents such as neurotransmitters and xenobiotics capable of disturbing neural function. The barri...
journal_title:Journal of anatomy
pub_type: 杂志文章,评审
doi:10.1046/j.1469-7580.2002.00064.x
更新日期:2002-06-01 00:00:00
abstract::The role of the neural arch in weight transmission in the cervical and upper thoracic regions of the vertebral column has been investigated. Measurements at the levels of C2, C4, C6, C7, T1 and T5 vertebrae were made in 44 adult male vertebral columns. At each level, the area of the inferior surface of the body was co...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1986-10-01 00:00:00
abstract::An ultrastructural study was undertaken on cartilage resorption at the site of initial endochondral bone formation in the mouse mandibular condyle on d 16 of pregnancy. After resorbing the bone collar, the osteoclasts extended their cell processes into the cartilage matrix and made contact with hypertrophic chondrocyt...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1046/j.1469-7580.1997.19110065.x
更新日期:1997-07-01 00:00:00
abstract::The mammalian cochlea is a remarkable sensory organ, capable of perceiving sound over a range of 10(12) in pressure, and discriminating both infrasonic and ultrasonic frequencies in different species. The sensory hair cells of the mammalian cochlea are exquisitely sensitive, responding to atomic-level deflections at s...
journal_title:Journal of anatomy
pub_type: 杂志文章,评审
doi:10.1111/joa.12314
更新日期:2016-02-01 00:00:00
abstract::This study was prompted by the prospect of transgenic pigs providing donor hearts for transplantation in human recipients. Autonomic innervation is important for the control of cardiac dynamics, especially in the conduction system. Our objective was to assess the relative distribution of autonomic nerves in the pig he...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1046/j.1469-7580.1999.19530341.x
更新日期:1999-10-01 00:00:00
abstract::The fabella is a sesamoid bone located in the gastrocnemius behind the lateral femoral condyle. In humans, fabellae are 3.5 times more common today than they were 100 years ago, with prevalence rates varying between and within populations. In particular, fabellae have been assumed to be more common in Asians than non-...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.13091
更新日期:2020-02-01 00:00:00
abstract::Apart from molecular data, nearly all the evidence used to study primate relationships comes from hard tissues. Here, we provide details of the first parsimony and Bayesian cladistic analyses of the order Primates based exclusively on muscle data. The most parsimonious tree obtained from the cladistic analysis of 166 ...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2011.01403.x
更新日期:2011-09-01 00:00:00
abstract::By relating an animal's morphology to its functional role and the behaviours performed, we can further develop our understanding of the selective factors and constraints acting on the adaptations of great apes. Comparison of muscle architecture between different ape species, however, is difficult because only small sa...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2011.01383.x
更新日期:2011-08-01 00:00:00
abstract::It is a challenge to understand how barn owls (Tyto alba) reduce noise during flight to be able to hunt small mammals by audition. Several specializations of the wing and the wing feathers have been implicated in noise reduction. What has been overlooked so far are the fringes at the inner vanes of remiges. We demonst...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2012.01504.x
更新日期:2012-07-01 00:00:00
abstract::The koala has an inguinoaxillary lymph trunk on either side of the ventral midline, and this carries efferent lymph from the superficial inguinal lymph node directly to the deep axillary lymph node. The superficial lymph nodes are large and soft compared with those of the domestic species, and each lymph centre usuall...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1991-08-01 00:00:00
abstract::Although the interspecific scaling of tetrapods is well understood, remarkably little work has been done on the ontogenetic scaling within tetrapod species, whether fossil or recent. Here the ontogenetic allometry of the femur, humerus, and tibia was determined for 23 species of non-avian dinosaur by regressing log-tr...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2010.01253.x
更新日期:2010-08-01 00:00:00
abstract::Mammalian pregnancy involves remodelling of the uterine epithelium to enable placentation. In marsupials, such remodelling has probably played a key role in the transition from ancestral invasive placentation to non-invasive placentation. Identifying uterine alterations that are unique to marsupials with non-invasive ...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.13162
更新日期:2020-06-01 00:00:00
abstract::Observations have been made on the rabbit sciatic nerve distal to a transection, with survival periods of up to 26 mo and prevention of reinnervation. It was confirmed that the nerve becomes compartmented by fibroblast processes and that a zone of fine collagen fibrils develops around the Schwann cell columns that con...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1046/j.1469-7580.1998.19240529.x
更新日期:1998-05-01 00:00:00
abstract::Invasive species are a global scourge and often negatively impact native species. Understanding the expansion and dispersal limits of these species is essential. As previous studies have demonstrated increased locomotor performance for populations at the edge of the range of expanding populations, studies of locomotio...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.13063
更新日期:2019-12-01 00:00:00
abstract::The rete testis in the domestic fowl (Gallus gallus domesticus), Japanese quail (Coturnix coturnix japonica), guinea-fowl (Numida meleagris galeata) and drake (Anas platyrhynchos) was studied histologically and with both the scanning and transmission electron microscopes. All the birds have rete epithelial cells varyi...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1982-08-01 00:00:00
abstract::Although the development of the avian skeleton has attracted considerable attention, most of the studies have been concentrated on the embryonic period, while studies on the postnatal period are rare. We studied the postnatal development of the skeleton in two phylogenetically distant birds, an altricial passerine Acr...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.13303
更新日期:2021-02-01 00:00:00
abstract::The study of inborn genetic errors can lend insight into mechanisms of normal human development and congenital malformations. Here, we present the first detailed comparison of cranial and neuro pathology in two exceedingly rare human individuals with cyclopia and alobar holoprosencephaly (HPE) in the presence and abse...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12343
更新日期:2015-09-01 00:00:00
abstract::The arteries of the skin have been postulated to form a profound plexus at the dermal/hypodermal junction and a superficial plexus in the papillary dermis. Our article aims to rebut this concept and to provide an alternative description of the arrangement of the dermal arteries. Employing a novel technique, we produce...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12113
更新日期:2013-12-01 00:00:00
abstract::During ageing, a progressive loss of skeletal muscle mass and a decrease in muscle strength and endurance take place, in the condition termed sarcopenia. The mechanisms of sarcopenia are complex and still unclear; however, it is known that muscle atrophy is associated with a decline in the number and/or efficiency of ...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12429
更新日期:2016-05-01 00:00:00
abstract::Maternal intraperitoneal administration of 1 mg/kg 5-azacytidine to pregnant S1c:ICR mice on gestational Day 7.5 resulted in a high incidence of exencephalic offspring. Histological examination of untreated 7.5 days mouse embryos revealed that the head folds were formed in the anterior halves of the embryos, whereas t...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1985-05-01 00:00:00
abstract::Although laryngeal morphology often reflects adaptations for vocalization, the structural consequences of selection for particular aspects of vocal behavior remain poorly understood. In this study, we investigated the effects of increased ultrasonic calling in pups on the adult larynx morphology in selectively bred ra...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.13366
更新日期:2021-01-21 00:00:00
abstract::The process of anatomical ductal obliteration appears to be gradual and to involve proliferation of intima and media (mainly the latter) producing mounds, mucoid-filled spaces and fragmentation of the internal elastic membrane. Dissociation of the inner media may also be involved. The persistent ductus can be recogniz...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1979-06-01 00:00:00
abstract::Anomalous connection of the inferior caval vein to the left atrium is exceedingly rare, and has even been considered by some authors an anatomic and embryologic impossibility. This study demonstrates for the first time the existence of this rare malformation, diagnosed on prenatal echo, and confirmed on post-mortem ex...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.13378
更新日期:2020-12-20 00:00:00
abstract::Peripheral sensory and autonomic neurons are known to possess insulin receptors. These have been considered to be of the peripheral type, i.e. similar to those of hepatic and fat cells rather than of the brain type which show dual specificity for both insulin and insulin-like growth factor (IGF-1). We have examined th...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1046/j.1469-7580.1997.19130431.x
更新日期:1997-10-01 00:00:00
abstract::The effects of varying periods of general protein-calorie undernutrition during early life on Purkinje cells in the cerebellum of the rat were examined. In Experiment 1, animals were undernourished from d 18 of gestation until either d 30 or d 60 of postnatal age, followed in some cases by a period of nutritional reha...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1992-10-01 00:00:00
abstract::A quantitative analysis of the motor innervation of intrafusal muscle fibres is described, based on teased silver-impregnated spindles of the tenuissimus muscle of the cat. Included in the analysis are the number and distribution of intrafusal branches of both skeletofusimotor (beta) and purely fusimotor (gamma) axons...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1994-08-01 00:00:00
abstract::The developing cortical surfaces of long bones are sculpted and modeled by periosteal osteoclasts and osteoblasts. These surfaces also receive the insertions of tendons and ligaments, and these insertion sites too are modeled to form the root systems that anchor them into the cortical bone. The regulatory molecules th...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12145
更新日期:2014-04-01 00:00:00