Abstract：
:Maternal intraperitoneal administration of 1 mg/kg 5-azacytidine to pregnant S1c:ICR mice on gestational Day 7.5 resulted in a high incidence of exencephalic offspring. Histological examination of untreated 7.5 days mouse embryos revealed that the head folds were formed in the anterior halves of the embryos, whereas the primitive streaks still remained in the posterior halves. At 12 hours after 5-azacytidine administration (8.0 days embryos), numerous pyknotic cells were observed in the neurectoderm of the head folds, in the embryonic ectoderm and the migrating mesoderm of the primitive streak region. These pyknotic cells had almost disappeared from the embryonic tissues, and few abnormalities were encountered, in embryos 24 hours after 5-azacytidine administration (8.5 days embryos), except for the slight reduction in thickness of the neurectoderm of the head folds compared with that in untreated 8.5 days embryos. In untreated 9.5 days embryos, the head folds had entirely closed along the anterior neuroaxes, whereas those treated with 5-azacytidine 48 hours earlier displayed head folds that were open in various degrees along the neuroaxes anterior to the fourth ventricle. The primary cause of 5-azacytidine-induced exencephaly is considered to be attributable to a powerful cell-killing action of 5-azacytidine and the subsequent loss of germinal cells in the neurectoderm of the head folds. The precise mechanisms by which this damage results in the failure of neural tube closure in the cephalic region remains unclear.
journal_name
J Anatjournal_title
Journal of anatomyauthors
Takeuchi IK,Takeuchi YKsubject
Has Abstractpub_date
1985-05-01 00:00:00pages
403-12eissn
0021-8782issn
1469-7580journal_volume
140 ( Pt 3)pub_type
杂志文章abstract：:Peripheral sensory and autonomic neurons are known to possess insulin receptors. These have been considered to be of the peripheral type, i.e. similar to those of hepatic and fat cells rather than of the brain type which show dual specificity for both insulin and insulin-like growth factor (IGF-1). We have examined th...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.1997.19130431.x
更新日期：1997-10-01 00:00:00
abstract：:The permeability of the skin of fetal rats between 14 and 21 days of intrauterine life was investigated by injecting lanthanum nitrate solution subepidermally and by exposing the external surface of other fetuses to the same solution. Up to the age of 18 days, the epidermis was freely permeable from the basal surface ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1983-03-01 00:00:00
abstract：:The purpose of this study was to examine and describe the sequence of events involved in long-term biological reconstruction of a tendon-bone interface following surgical reattachment. Patellar tendon re-attachment in the adult sheep was used to investigate and describe the biological components involved in healing an...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2007.00699.x
更新日期：2007-03-01 00:00:00
abstract：:In the infant the region lateral to the sella turcica which is traditionally termed the 'cavernous sinus' is composed of 3 individual compartments. The aim of this study was to demonstrate a similar compartmentation of the adult cavernous sinus and to identify and quantify the adipose bodies which are located within t...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.2000.19740681.x
更新日期：2000-11-01 00:00:00
abstract：:Tooth germs from the mandibles of 5 stillborn infants were examined by scanning electron microscopy and light microscopy in order to investigate the surgace structure at different stages of mineralization. The surface of the completed enamel of the incisal third of the incisors was smooth, indicating that amelogenesis...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1977-04-01 00:00:00
abstract：:Enzymatic degradation followed by lectin application was carried out on specimens of the rabbit oviduct. The sequential application of the glycosidases (neuraminidase, alpha-L-fucosidase, beta-galactosidase and alpha-mannosidase) and lectins (peanut, winged pea, wheat germ and soybean) seem promising as an effective m...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1985-06-01 00:00:00
abstract：:We present a simple and quick system for accurately scoring the developmental progress of mouse embryos harvested on embryonic day 14 (E14.5). Based solely on the external appearance of the maturing forelimb, we provide a convenient way to distinguish six developmental sub-stages. Using a variety of objective morphome...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12590
更新日期：2017-05-01 00:00:00
abstract：:The distribution and form of amoeboid microglia in the brain of neonatal rats have been studied with the light and electron microscope. With the silver carbonate method of Rio-Hortega, two major 'colonies' of amoeboid microglia are identified: (1) in the supraventricular corpus callosum in which the nerve fibres are w...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1976-02-01 00:00:00
abstract：:Neutron diffraction measurements of the orientation of the apatite crystals show a significant preference of their c-axes for the vertical direction. This preference increases from bottom to top of each vertebral body and is substantially greater for the second than for the fifth lumbar vertebrae. This is in line with...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1979-03-01 00:00:00
abstract：:During long bone development the original cartilaginous model in mammals is replaced by bone, but at the long bone endings the avascular articular cartilage remains. Before the articular cartilage attains structural maturity it undergoes reorganization, and molecules such as vascular endothelial growth factor (VEGF) a...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2011.01377.x
更新日期：2011-06-01 00:00:00
abstract：:Knowledge of variations in the morphology of normal myelinated peripheral nerve fibres is fundamental to subsequent interpretation of neuropathology. It would be advantageous for structural analysis of normal variations to be based on entire myelin internodes, but acquisition of such data via the classic approach of n...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1995-10-01 00:00:00
abstract：:Since their discovery in different human tissues by Zimmermann in 1898, primary cilia have been found in the vast majority of cell types in vertebrates. Primary cilia are considered to be cellular antennae that occupy an ideal cellular location for the interpretation of information both from the environment and from o...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12360
更新日期：2015-10-01 00:00:00
abstract：:The number of neurons and glia in the mouse abducens nerve nucleus was estimated at 6, 25, 28 and 31 months of age. There was no significant variation in either the number of neurons (mean 118) or glia (mean 168) or in the glia to neuron ratio (mean 1.42) with age. Mean neuronal and glial nuclear diameters also remain...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1989-10-01 00:00:00
abstract：:The proximal stump of the optic nerve was examined by electron microscopy from 1 d to 8 wk (dpo/wpo) after intraorbital transection. At 1 dpo a layer of axonal, cytoplasmic and myelin debris approximately 15 microns thick was present at the cut end. A zone approximately 25 microns thick of abnormal and partly degenera...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1994-12-01 00:00:00
abstract：:The dentate nucleus is phylogenetically the most recent nucleus in the cerebellum. Owing to its connections to the thalamus and the prefrontal cortex it may be involved in the symptomathology in schizophrenia and other psychiatric illnesses. In this stereological study we implemented the smooth fractionator, which com...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.0021-8782.2004.00337.x
更新日期：2004-10-01 00:00:00
abstract：:Age-related changes are reported in the rat suprapatella: a fibrocartilage that resists compression of the quadriceps tendon against the femur in the flexed knee. The suprapatella was studied by histology, immunohistochemistry and electron microscopy in rats aged 11-14 weeks, and 12, 15, 18 and 24 months. Type II coll...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1991-12-01 00:00:00
abstract：:The three kinds of keratinized epithelium evident on gross examination of the soft palate of Wistar albino rats were studied by scanning and transmission electron microscopy. Scanning indicated a central area where the epithelium showed numerous fine folds and papillae, more lateral areas which were smooth, and most l...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1976-09-01 00:00:00
abstract：:Kokartus honorarius from the Middle Jurassic (Bathonian) of Kyrgyzstan is one of the oldest salamanders in the fossil record, characterized by a mixture of plesiomorphic morphological features and characters shared with crown-group salamanders. Here we present a detailed histological analysis of its long bones. The an...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12281
更新日期：2015-04-01 00:00:00
abstract：:Chromaffin cells were observed singly or in clusters in the heart and sympathetic cord of 2 genera of dipnoan fish, Protopterus and Lepidosiren. They were invariably found in close association with the autonomic sympathetic nervous system and at sites where chromaffin cells or their precursors are situated in mammals ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1993-10-01 00:00:00
abstract：:Myocardial hyperplasia is generally considered to occur only during fetal development. However, recent evidence suggests that this type of response may also be triggered by cardiac overload after birth. In congenital heart disease, loading conditions are frequently abnormal, thereby affecting ventricular function. We ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2008.00853.x
更新日期：2008-03-01 00:00:00
abstract：:The study of inborn genetic errors can lend insight into mechanisms of normal human development and congenital malformations. Here, we present the first detailed comparison of cranial and neuro pathology in two exceedingly rare human individuals with cyclopia and alobar holoprosencephaly (HPE) in the presence and abse...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12343
更新日期：2015-09-01 00:00:00
abstract：:A histological study has shown that considerable amounts of lipid accumulate in the oxyntico-peptic cells of the proventriculus of domestic fowls deprived of food. Lipid droplets were first seen in the cells 6 hours after commencing the fast and they reached a maximum in 24 hours; a decrease was detected histologicall...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1975-12-01 00:00:00
abstract：:The examination of endocranial data of archosauriforms has led to advances on the evolution of body size, nerve pathways, and sensory abilities. However, much of that research has focused on bird-line archosaurs, resulting in a skewed view of Archosauria. Phytosauria, a hypothesized sister taxon to or early-branching ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12668
更新日期：2017-11-01 00:00:00
abstract：:Uptake and translocation of particulates across the mucosal barrier of the gastrointestinal (GI) tract is now generally recognised but the effect of pathophysiologically induced changes on this process is less well established. This study evaluated the effect of diabetes mellitus on GI absorption of particles, compari...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1996-12-01 00:00:00
abstract：:As the uterus enlarges to accommodate the growing fetus during pregnancy, the cervix behaves essentially as a barrier. During ripening and delivery, it needs to become soft and distensible to allow dilation and the passage of the conceptus. As the transformations of the collagen-containing fibres are known to be essen...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.2003.00227.x
更新日期：2003-10-01 00:00:00
abstract：:The morphological features of odontoblast processes in young kitten odontoblasts were studied by thin section and freeze-fracture electron microscopy. Freeze-fracture replication revealed depressions with particles on the plasma membranes of the proximal parts of odontoblast processes. Comparison with thin sections su...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1984-05-01 00:00:00
abstract：:Stem cells hold great promise for regenerative medicine but remain elusive in many tissues, including the small intestine, where it is well accepted that the epithelium is maintained by intestinal stem cells located in the crypts. The lack of established markers to prospectively identify intestinal stem cells has nece...
journal_title：Journal of anatomy
pub_type： 杂志文章,评审
doi：10.1111/j.1469-7580.2008.00925.x
更新日期：2008-07-01 00:00:00
abstract：:Keratinocytes, in response to irritants, secrete pro-inflammatory mediators which recruit and activate immune and mesenchymal cells, including fibroblasts, to repair the skin. Fibroblasts respond by synthesising collagen and promoting the crosslinking extracellular matrix (ECM). We recently showed that the deletion of...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12442
更新日期：2016-05-01 00:00:00
abstract：:M. semitendinosus and m. trapezius (portion) were removed from eight miniature pigs ranging from 21 to 160 days of age and eight age-control as well as eight weight-control commercial Large White pigs. Complete transverse frozen sections were obtained for each muscle sample and stained for various enzyme activities in...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1986-08-01 00:00:00
abstract：:The fine structure of the intercellular junctions of the hen parathyroid gland was studied using freeze-fracture replicas and thin sections. In the conventional thin sections, desmosomes, intermediate junctions (maculae adherentes) and gap junctions were observed, and in the lanthanum-fixed sections, tight junctions (...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1982-09-01 00:00:00
