Abstract：
:Since their discovery in different human tissues by Zimmermann in 1898, primary cilia have been found in the vast majority of cell types in vertebrates. Primary cilia are considered to be cellular antennae that occupy an ideal cellular location for the interpretation of information both from the environment and from other cells. To date, in mammalian thyroid gland, primary cilia have been found in the thyrocytes of humans and dogs (fetuses and adults) and in rat embryos. The present study investigated whether the existence of this organelle in follicular cells is a general event in the postnatal thyroid gland of different mammals, using both immunolabeling by immunofluorescence and electron microscopy. Furthermore, we aimed to analyse the presence of primary cilia in various thyroid cell lines. According to our results, primary cilia are present in the adult thyroid gland of most mammal species we studied (human, pig, guinea pig and rabbit), usually as a single copy per follicular cell. Strikingly, they were not found in rat or mouse thyroid tissues. Similarly, cilia were also observed in all human thyroid cell lines tested, both normal and neoplastic follicular cells, but not in cultured thyrocytes of rat origin. We hypothesize that primary cilia could be involved in the regulation of normal thyroid function through specific signaling pathways. Nevertheless, further studies are needed to shed light on the permanence of these organelles in the thyroid gland of most species during postnatal life.
journal_name
J Anatjournal_title
Journal of anatomyauthors
Utrilla JC,Gordillo-Martínez F,Gómez-Pascual A,Fernández-Santos JM,Garnacho C,Vázquez-Román V,Morillo-Bernal J,García-Marín R,Jiménez-García A,Martín-Lacave Idoi
10.1111/joa.12360subject
Has Abstractpub_date
2015-10-01 00:00:00pages
550-60issue
4eissn
0021-8782issn
1469-7580journal_volume
227pub_type
杂志文章abstract：:We have explored the innervation of the rainbow trout (O. mykiss) liver using immunohistochemical procedures and light microscopy to detect in situ protein gene product 9.5 and neuronal nitric oxide synthase immunoreactivities (PGP-IR and NOS-IR). The results showed PGP-IR nerve fibres running with the extralobular bi...
journal_title：Journal of anatomy
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abstract：:A monoclonal antibody SBU-3 raised against an antigen expressed by the binucleate cells in the trophoblast of the sheep placentome crossreacts with an antigen expressed by binucleate cells in the placenta of the deer and the cow. This monoclonal antibody has been used to study the distribution of this subpopulation of...
journal_title：Journal of anatomy
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journal_title：Journal of anatomy
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journal_title：Journal of anatomy
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abstract：:Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease with clinical, pathological and genetic overlap with frontotemporal dementia (FTD). No longer viewed as one disease with a single unified cause, ALS is now considered to be a clinicopathological syndrome resulting from a complex convergence of ...
journal_title：Journal of anatomy
pub_type： 杂志文章,评审
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journal_title：Journal of anatomy
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journal_title：Journal of anatomy
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更新日期：1978-05-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12610
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1996-08-01 00:00:00
abstract：:Anatomical specimens used in human or veterinary anatomy laboratories are usually prepared with formaldehyde (a cancerous and teratogenic substance), glycerin (an expensive and viscous fluid), or ethanol (which is flammable). This research aimed to verify the viability of an aqueous 30% sodium chloride solution for pr...
journal_title：Journal of anatomy
pub_type： 杂志文章
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更新日期：2014-07-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1983-03-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
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更新日期：2001-01-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.2003.00227.x
更新日期：2003-10-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1989-02-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.2002.00119.x
更新日期：2002-12-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1989-04-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.2003.00184.x
更新日期：2003-06-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章,评审
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journal_title：Journal of anatomy
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journal_title：Journal of anatomy
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journal_title：Journal of anatomy
pub_type： 杂志文章
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更新日期：2012-11-01 00:00:00
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journal_title：Journal of anatomy
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更新日期：2009-05-01 00:00:00
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journal_title：Journal of anatomy
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更新日期：2005-03-01 00:00:00
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journal_title：Journal of anatomy
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journal_title：Journal of anatomy
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journal_title：Journal of anatomy
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abstract：:As a member of the most basal clade of extant ray-finned fishes (actinopterygians) and of one of the most basal clades of osteichthyans (bony fishes + tetrapods), Polypterus can provide insights into the ancestral anatomy of both ray-finned and lobe-finned fishes, including those that gave rise to tetrapods. The pecto...
journal_title：Journal of anatomy
pub_type： 杂志文章
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