Abstract:
:Knowledge of variations in the morphology of normal myelinated peripheral nerve fibres is fundamental to subsequent interpretation of neuropathology. It would be advantageous for structural analysis of normal variations to be based on entire myelin internodes, but acquisition of such data via the classic approach of nerve fibre teasing has been hindered by limitations in optical resolution and specimen preparation. This study addressed these limitations through a new confocal imaging method which permits detailed visualisation of individual myelinated fibres in intact peripheral nerve trunks, and quantitated previously unrecognised patterns of morphological variation within normal internodes. The study focused particularly on Schmidt-Lanterman incisures, the narrow cytoplasmic channels which traverse normal compact myelin and provide foci for disruption of the compact sheath in a number of peripheral neuropathies. Analysis was based on confocal fluorescence images of multiple sequential internodes, traced within posterior tibial nerve trunks of adult male Sprague-Dawley rats. The strength of relationships between internodal size variables (length, fibre diameter, myelin sheath thickness) and total number of incisures per internode were documented. Each internode was divided into 4 regions of equivalent length (regions 1-4), and variations in the distribution of incisures and Schwann cell nuclear location were evaluated. Regional variations were consistent, irrespective of differences in fibre diameter, myelin sheath thickness, and internodal length. Expressed in terms of proximodistal orientation, there was a unimodal distribution of incisures within internodes of this fibre population (diameter range 5-9 microns), with region 3 containing the highest number of incisures and region 4 the lowest (P < 0.05). The Schwann cell nucleus was located more frequently in region 3 than in region 2 (P < 0.01). Contrary to previous reports, an incisure was found in close association with the nucleus in at least 50% of internodes. Documentation of frequent incisure-nuclear association and consistent patterns of variation within internodes extends knowledge of the microanatomy of normal peripheral nerve, and may provide insight into the functional role of incisures. Demonstration of such patterns in normal nerve may contribute to the understanding of pathological change, for example progression of ovoid formation from midinternodal regions during wallerian degeneration.
journal_name
J Anatjournal_title
Journal of anatomyauthors
Reynolds RJ,Heath JWsubject
Has Abstractpub_date
1995-10-01 00:00:00pages
369-78eissn
0021-8782issn
1469-7580journal_volume
187 ( Pt 2)pub_type
杂志文章abstract::The occurrence of pneumatisation in the skull of the adult domestic fowl was investigated in eight birds by gross and histological examination. It was found to occur regularly throughout the neurocranium and in the quadrate and variably in the mandible, but to be absent in the facial skeleton. Close agreement was foun...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1984-06-01 00:00:00
abstract::Differences are reported in the total calcified tissue/bone marrow ratios and in the total thickness of cortical calcified tissue (lamellar bone and calcified fibrocartilage) between the attachment sites of the quadriceps tendon and the patellar ligament in man. The greatest amount of calcified tissue is at the insert...
journal_title:Journal of anatomy
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journal_title:Journal of anatomy
pub_type: 杂志文章,评审
doi:10.1111/j.1469-7580.2007.00777.x
更新日期:2007-08-01 00:00:00
abstract::The present study investigated, by immunohistochemistry, the postnatal occurrence and anatomical localisation of some bone and cartilage proteins and proteoglycans in the rat coronal sutural region. Thirty two Sprague-Dawley rats, four in each group, were killed at ages 3, 5, 8, 10, 15, 30, 50 and 100 days and the sut...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1990-12-01 00:00:00
abstract::The astroglial lineage consists of heterogeneous cells instrumental for normal brain development, function and repair. Unfortunately, this heterogeneity complicates research in the field, which suffers from lack of truly specific and sensitive astroglial markers. Nevertheless, single astroglial markers are often used ...
journal_title:Journal of anatomy
pub_type: 杂志文章,评审
doi:10.1111/joa.12948
更新日期:2019-09-01 00:00:00
abstract::An autoradiographic study of neuronal and glial production was carried out in the indusium griseum of mice. Most neurons were produced between 13 and 15 days post-conception. One part of the glial population underwent its last or second-last divisions between 14 and 16 days post-conception, while the other continued t...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1978-05-01 00:00:00
abstract::Although the development of the avian skeleton has attracted considerable attention, most of the studies have been concentrated on the embryonic period, while studies on the postnatal period are rare. We studied the postnatal development of the skeleton in two phylogenetically distant birds, an altricial passerine Acr...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.13303
更新日期:2021-02-01 00:00:00
abstract::Small clusters of extra large muscle fibres were identified in hindlimb muscles of neonatal mice (strain C57BL/10ScSn). At two days of age they had a significantly greater cross-sectional area than their normal counterparts (P less than 0.01). Fibre typing methods (NADH-tetrazolium reductase, ATPase and phosphorylase)...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1990-06-01 00:00:00
abstract::The aim of the present study was to estimate mean neuronal volume and absolute size distributions of the neocortical neurons in brains from controls and AD patients using stereological methods based on unbiased principles to determine whether changes in absolute cell size are part of the neuropathological pattern of A...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1046/j.1469-7580.2001.19840481.x
更新日期:2001-04-01 00:00:00
abstract::The differentiation and patterning of tendon fibroblasts is at present a poorly understood aspect of musculoskeletal development in the vertebrate limb. Precursors of tendon fibroblasts originate in the somatic mesoderm adjacent to the early limb bud and gradually become incorporated into the limb mesenchyme as develo...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1046/j.1469-7580.2003.00145.x
更新日期:2003-01-01 00:00:00
abstract::Alveolar macrophages were isolated from the lungs of hamsters by lavage and centrifugation. The harvesting procedure yielded about 5.2 X 10(6) cells per animal and the majority of these cells were viable as assessed by a Trypan blue exclusion test. Monolayers of macrophages were labelled with a series of FITC-conjugat...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1985-03-01 00:00:00
abstract::The surface coating of the pneumonocytes in the lungs of five human neonates was studied by conventional electron microscopy and by cytochemical techniques. These techniques included staining with colloidal iron oxide, cationic ferritin, Ruthenium red, Ruthenium hexamine trichloride, high iron diamine and the periodic...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1984-09-01 00:00:00
abstract::Comb and wattle tissues, which consist of layers of epidermis, dermis and central connective tissue, are known to contain sulphated glycosaminoglycans (GAGs) including dermatan sulphate and chondroitin sulphate-dermatan sulphate copolymers. Little is known about distribution of these CAGs in each tissue. The objective...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1996-12-01 00:00:00
abstract::The onset and evolution of the meiotic prophase were assessed by histological and cytological techniques in fetal and neonatal ovaries obtained from day 13 postcoitum to day 11 postpartum in the golden hamster (Mesocricetus auratus). The histological technique based on the Feulgen stain and the cytological technique b...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1981-06-01 00:00:00
abstract::Excisional wounds were inflicted on the palatal mucoperiosteum of beagle pups at intervals from 3 to 31 days before the animals were killed, when the animals were perfused and the tissue examined by electron, microscopy. Fibroblasts with the morphological characteristics of myofibroblasts, including bundles of intrace...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1980-05-01 00:00:00
abstract::Cellullar deficits are replenished within the central nervous system (CNS) by progenitors to maintain integrity and recover function after injury. NG2 proteoglycan-expressing progenitors replenish oligodendrocyte populations, but the nature of NG2 proteoglycan may not indicate a restricted population of progenitors. A...
journal_title:Journal of anatomy
pub_type: 杂志文章,评审
doi:10.1111/j.1469-7580.2005.00480.x
更新日期:2005-12-01 00:00:00
abstract::The effects of excess iodine on the development of the thyroid gland of chick embryos was assessed following injections of potassium iodide prior to incubation. Iodide injection resulted in a significantly greater thyroid gland weight (goitre) on Day 18 of incubation and a delay in hatching. Histological studies of th...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1991-06-01 00:00:00
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journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12506
更新日期:2016-11-01 00:00:00
abstract::Apart from molecular data, nearly all the evidence used to study primate relationships comes from hard tissues. Here, we provide details of the first parsimony and Bayesian cladistic analyses of the order Primates based exclusively on muscle data. The most parsimonious tree obtained from the cladistic analysis of 166 ...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2011.01403.x
更新日期:2011-09-01 00:00:00
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journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1979-08-01 00:00:00
abstract::Fascia in the veterinary sciences is drawing attention, such that physiotherapists and animal practitioners are now applying techniques based on the concept of fascia studies in humans. A comprehensive study of fascia is therefore needed in animals to understand the arrangement of the fascial layers in an unguligrade ...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.13064
更新日期:2019-12-01 00:00:00
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journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1983-09-01 00:00:00
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journal_title:Journal of anatomy
pub_type: 杂志文章,评审
doi:10.1111/joa.12063
更新日期:2014-01-01 00:00:00
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journal_title:Journal of anatomy
pub_type: 更正并重新发布的文章,杂志文章
doi:
更新日期:2003-09-01 00:00:00
abstract::The common internal iliac artery in the sheep gives rise to the arteries which are the primary source of blood to the uterus. We have used a vascular occluder placed on the common internal iliac artery of the pregnant sheep to induce and study the effects of chronic fetal hypoxaemia. We have noted that uterine blood f...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1995-08-01 00:00:00
abstract::Nearly two thirds of the approximately 700 species of living salamanders are lungless. These species respire entirely through the skin and buccopharyngeal mucosa. Lung loss dramatically impacts the configuration of the circulatory system but the effects of evolutionary lung loss on cardiac morphology have long been co...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12535
更新日期:2017-01-01 00:00:00
abstract::Muscle moment arms were measured for major muscles of the pelvic limb of the ostrich (Struthio camelus) in order to assess specific functional behaviour and to apply this to locomotor performance. Pelvic limbs of six juvenile ostriches were used for this study. The tendon travel technique was used to measure moment ar...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2007.00762.x
更新日期:2007-09-01 00:00:00
abstract::Enzymatic degradation followed by lectin application was carried out on specimens of the rabbit oviduct. The sequential application of the glycosidases (neuraminidase, alpha-L-fucosidase, beta-galactosidase and alpha-mannosidase) and lectins (peanut, winged pea, wheat germ and soybean) seem promising as an effective m...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1985-06-01 00:00:00
abstract::Mammalian Langerhans cells (LC) are epidermal dendritic cells which originate in bone marrow and migrate toward the T cell area of lymph nodes, where they act as professional antigen-presenting cells. A variety of cell surface markers, such as the ectoenzyme adenosine triphosphatase (ATPase), Ia and CDla antigens, hav...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1046/j.1469-7580.2001.19940493.x
更新日期:2001-10-01 00:00:00
abstract::Quantitative craniometrical traits have been successfully incorporated into population genetic methods to provide insight into human population structure. However, little is known about the degree of genetic and non-genetic influences on the phenotypic expression of functionally based traits. Many studies have assesse...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2008.01015.x
更新日期:2009-01-01 00:00:00