Abstract：
:The differentiation and patterning of tendon fibroblasts is at present a poorly understood aspect of musculoskeletal development in the vertebrate limb. Precursors of tendon fibroblasts originate in the somatic mesoderm adjacent to the early limb bud and gradually become incorporated into the limb mesenchyme as development proceeds. It is unclear whether these progenitor cells are committed to the tendon lineage at this early stage, or whether cells become committed only as they are incorporated into a developing tendon. Following a review of our current knowledge of early tendon development, we present recent results from our preliminary studies looking at tendon cell commitment. Using a lacZ encoding replication-deficient retrovirus, we have mapped regions of the early limb bud that contain presumptive tendon progenitor cells, and later used these sites for implanting labelled fetal tendon fibroblasts into developing limbs. Following implantation, we found that these cells successfully re-incorporated into developing proximal and distal tendons, but also surprisingly contributed to other tissue lineages within the limb. Our results suggest that fetal tendon fibroblasts may not be irreversibly committed to a tendon cell fate in the limb and may be somewhat plastic in their ability to integrate into other tissue lineages during development.
journal_name
J Anatjournal_title
Journal of anatomyauthors
Oldfield SF,Evans DJdoi
10.1046/j.1469-7580.2003.00145.xkeywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
153-64issue
1eissn
0021-8782issn
1469-7580journal_volume
202pub_type
杂志文章abstract：:Facial size reduction and facial retraction are key features that distinguish modern humans from archaic Homo. In order to more fully understand the emergence of modern human craniofacial form, it is necessary to understand the underlying evolutionary basis for these defining characteristics. Although it is well estab...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2009.01162.x
更新日期：2010-01-01 00:00:00
abstract：:The ventricle of the salmonid heart consists of an outer compact layer of circumferentially arranged cardiomyocytes encasing a spongy myocardium that spans the lumen of the ventricle with a fine arrangement of muscular trabeculae. While many studies have detailed the anatomical structure of fish hearts, few have consi...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2009.01129.x
更新日期：2009-11-01 00:00:00
abstract：:A cutaneous branch of the suprascapular nerve was observed in 6 arms from 5 (4 male and 1 female) out of 61 Japanese cadavers. The suprascapular nerves with a cutaneous branch arose from essentially normal brachial plexuses. Every suprascapular nerve with a cutaneous branch had a normal course, and gave rise to the cu...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:Wallerian degeneration and dying-back pathology are two well-known cellular pathways capable of regulating the breakdown and loss of axonal and synaptic compartments of neurons in vivo. However, the underlying mechanisms and molecular triggers of these pathways remain elusive. Here, we show that loss of translation el...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2008.01007.x
更新日期：2008-12-01 00:00:00
abstract：:In this study we investigated immunohistochemically the distribution of VIP in ampullary and isthmic segments of the rabbit oviduct at different hormonal stages in order to correlate the presence of VIP with the morphological and functional differences between the two oviduct segments. Noticeable changes in the VIP-po...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1990-08-01 00:00:00
abstract：:In rats of 40, 49 and 59 days of age the positions of the femoral and tibial nutrient foramina were determined by direct measurement, using a travelling microscope. The femoral nutrient foramen remained constant in position with increasing age, whereas the tibial nutrient foramen moved relatively nearer to the distal ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1978-03-01 00:00:00
abstract：:The surface coating of the alveolar macrophages and pneumonocytes of hamster lung was studied using an electron microscopy technique. Slices of lung tissue were fixed in aldehyde, labelled with a battery of lectin-horseradish peroxidase conjugates, incubated in a diaminobenzidine-hydrogen peroxide medium and then post...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1986-06-01 00:00:00
abstract：:The study of the underlying mechanisms by which cells respond to mechanical stimuli, i.e. the link between the mechanical stimulus and gene expression, represents a new and important area in the morphological sciences. Several cell types ('mechanocytes'), e.g. osteoblasts and fibroblasts as well as smooth, cardiac and...
journal_title：Journal of anatomy
pub_type： 杂志文章,评审
doi：10.1046/j.1469-7580.1999.19430323.x
更新日期：1999-04-01 00:00:00
abstract：:Electron microscopic appearances of Xenopus laevis axial myotome cells were examined through Stages 22-41 (Nieuwkoop & Faber, 1956). Differentiated contractile structures were not observed in myotome cells at or before Stage 22. At Stages 24-25, myofibrils appeared both as disordered strands in association with tubula...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1988-08-01 00:00:00
abstract：:The dentate nucleus is phylogenetically the most recent nucleus in the cerebellum. Owing to its connections to the thalamus and the prefrontal cortex it may be involved in the symptomathology in schizophrenia and other psychiatric illnesses. In this stereological study we implemented the smooth fractionator, which com...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.0021-8782.2004.00337.x
更新日期：2004-10-01 00:00:00
abstract：:Standard immunohistochemical methods were used to detect the presence of vimentin, cytokeratin 8, cytokeratin 18, macrophages and Langerhans cells in the human tonsillar epithelium in formalin-fixed and frozen tissue specimens. Vimentin detection was restricted to infiltrating cells of the lymphoid series, dendritic a...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.2001.19960663.x
更新日期：2001-12-01 00:00:00
abstract：:Astyanax brucutu is a peculiar species of Neotropical tetra endemic from the Chapada Diamantina, a large plateau in northeastern Brazil. Individuals of this species undergo a dramatic ontogenetic shift in their diet that is accompanied by equally remarkable changes in their feeding apparatus. Whereas juveniles of A. b...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.13280
更新日期：2020-12-01 00:00:00
abstract：:The sacroiliac joint (SIJ) is responsible for weight transmission between the spine and lower extremity. However, details of the structure and function of the SIJ remain unclear. In a previous study, we devised a method of quantitatively evaluating the level of degeneration of the SIJ using an age estimation procedure...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12765
更新日期：2018-02-01 00:00:00
abstract：:Seminiferous tubules develop from sex cords, which are embryonic structures with simple C-shaped arches. Histologically, the epithelium of adult mouse seminiferous tubules has been divided into 12 stages based on the associations of spermatogenic cells in four cycles of spermatogenesis. However, the gross characterist...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12375
更新日期：2015-11-01 00:00:00
abstract：:Anomalous connection of the inferior caval vein to the left atrium is exceedingly rare, and has even been considered by some authors an anatomic and embryologic impossibility. This study demonstrates for the first time the existence of this rare malformation, diagnosed on prenatal echo, and confirmed on post-mortem ex...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.13378
更新日期：2020-12-20 00:00:00
abstract：:A total histological grade does not necessarily distinguish between different manifestations of cartilage damage or degeneration. An accurate and reliable histological assessment method is required to separate normal and pathological tissue within a joint during treatment of degenerative joint conditions and to sub-cl...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2012.01513.x
更新日期：2012-07-01 00:00:00
abstract：:The secretory cells of the golden hamster (Mesocricetus auratus) oviductal epithelium on the day of ovulation were observed by light and electron microscopy. In the fimbriae two types of secretory cells were observed: one possessed secretory granules with electron-lucent matrices, prominent protrusions and many electr...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1991-04-01 00:00:00
abstract：:Colloidal carbon was injected intravenously into young rats to label circulating monocytes before making a stab wound in the brain. The rats were killed 3-16 days after the stab wound. Demonstration of non-specific esterase, thiamine pyrophosphatase and 5'-nucleotidase was carried out on the carbon-labelled macrophage...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1987-10-01 00:00:00
abstract：:The effects of chronic neuromuscular inactivity on the phenotype and size of muscle fibres in a fast ankle extensor (medial gastrocnemius, MG) and a fast ankle flexor (tibialis anterior, TA) muscle of the rat hindlimb were determined. Inactivity was produced by spinal cord isolation (SI), i.e. complete spinal cord tra...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2006.00665.x
更新日期：2007-01-01 00:00:00
abstract：:Calretinin is a calcium-binding protein found widely distributed in the central nervous system and chemosensory cells of the teleosts, but its presence in the peripheral nervous system of fishes is unknown. In this study we used Western blot analysis and immunohistochemistry to investigate the occurrence and distribut...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2007.00836.x
更新日期：2008-01-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2006.00615.x
更新日期：2006-09-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.13064
更新日期：2019-12-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1992-02-01 00:00:00
abstract：:Contracture of collagen fibres in the gubernaculum has been suggested as a mechanism responsible for fetal descent of the testis. We measured the collagen content of the gubernaculum, fetal thigh muscle and umbilical cord tissue by assaying its hydroxyproline and protein content in 194 male pig fetuses between 60 and ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1989-12-01 00:00:00
abstract：:Salivary mucins MG1 and MG2 have been found in the oral cavity where they perform several functions such as the formation of the mucous layer covering the oral mucosa and teeth. Recent studies have demonstrated their presence in other organs and tissues. The aim of this study was to determine their expression in human...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2008.01018.x
更新日期：2009-01-01 00:00:00
abstract：:A one day symposium of the Anatomical Society of Great Britain and Ireland was held at the Royal Free Hospital in London on the 17th September 1999, on the topic of 'Mechanisms of ageing and longevity'. The following are abstracts of communications and posters presented at the meeting. ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.2000.19620293.x
更新日期：2000-02-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.2003.00197.x
更新日期：2003-07-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12208
更新日期：2014-09-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.2001.19950591.x
更新日期：2001-11-01 00:00:00
abstract：:This study set out to determine the pattern of development and distribution of the interstitial cells of Cajal (ICC) in the intestinal tract of the equine fetus and neonate. Intestinal tissue samples from 12 naturally aborted equine fetuses and three euthanized neonates were collected and fixed in formalin prior to ap...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.0021-8782.2004.00315.x
更新日期：2004-07-01 00:00:00
