Abstract:
:Cellullar deficits are replenished within the central nervous system (CNS) by progenitors to maintain integrity and recover function after injury. NG2 proteoglycan-expressing progenitors replenish oligodendrocyte populations, but the nature of NG2 proteoglycan may not indicate a restricted population of progenitors. After injury, restorative spatiotemporal cues have the potential ability to regulate divergent fate-choices for NG2 progenitors, and NG2 progenitors are known to produce multiple cell types in vitro. Recent data suggest that NG2 expression is attenuated while protein levels remain high within injurious tissue; thus, NG2 expression is not static but transiently controlled in response to a dynamic interplay of environmental cues. Therefore, NG2 proteoglycan expression could label newly generated cells or be inherited by resident cell populations that produce oligodendrocytes for remyelination, astrocytes that provide trophic support and other cells that contribute to CNS function.
journal_name
J Anatjournal_title
Journal of anatomyauthors
Sellers DL,Horner PJdoi
10.1111/j.1469-7580.2005.00480.xkeywords:
subject
Has Abstractpub_date
2005-12-01 00:00:00pages
727-34issue
6eissn
0021-8782issn
1469-7580pii
JOA480journal_volume
207pub_type
杂志文章,评审abstract::Cetaceans face the challenge of maintaining equilibrium underwater and obtaining sensory input within a dense, low-visibility medium. The cetacean ear represents a key innovation that marked their evolution from terrestrial artiodactyls to among the most fully aquatic mammals in existence. Using micro-CT and histologi...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12548
更新日期:2017-02-01 00:00:00
abstract::The endoskeleton of elasmobranchs (sharks and rays) is comprised largely of unmineralized cartilage, differing fundamentally from the bony skeletons of other vertebrates. Elasmobranch skeletons are further distinguished by a tessellated surface mineralization, a layer of minute, polygonal, mineralized tiles called tes...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12508
更新日期:2016-11-01 00:00:00
abstract::A defining feature of dentitions in modern sharks and rays is the regulated pattern order that generates multiple replacement teeth. These are arranged in labio-lingual files of replacement teeth that form in sequential time order both along the jaw and within successively initiated teeth in a deep dental lamina. Two ...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12796
更新日期:2018-06-01 00:00:00
abstract::The heart is the first functioning organ to develop during embryogenesis. The formation of the heart is a tightly regulated and complex process, and alterations to its development can result in congenital heart defects. Mutations in sarcomeric proteins, such as alpha myosin heavy chain and cardiac alpha actin, have no...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12486
更新日期:2016-09-01 00:00:00
abstract::Injury to the energy-storing superficial digital flexor tendon is common in equine athletes and is age-related. Tenocytes in the superficial digital flexor tendon of adult horses appear to have limited ability to respond adaptively to exercise or prevent the accumulation of strain-induced microdamage. It has been sugg...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2007.00781.x
更新日期:2007-09-01 00:00:00
abstract::We have explored the innervation of the rainbow trout (O. mykiss) liver using immunohistochemical procedures and light microscopy to detect in situ protein gene product 9.5 and neuronal nitric oxide synthase immunoreactivities (PGP-IR and NOS-IR). The results showed PGP-IR nerve fibres running with the extralobular bi...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1046/j.1469-7580.1998.19320241.x
更新日期:1998-08-01 00:00:00
abstract::The objective of the present study was to measure the lines of action of 18 major muscles and muscle sub-regions crossing the glenohumeral joint of the human shoulder, and to compute the potential contribution of these muscles to joint shear and compression during scapular-plane abduction and sagittal-plane flexion. T...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2009.01090.x
更新日期:2009-08-01 00:00:00
abstract::Mammalian pregnancy involves remodelling of the uterine epithelium to enable placentation. In marsupials, such remodelling has probably played a key role in the transition from ancestral invasive placentation to non-invasive placentation. Identifying uterine alterations that are unique to marsupials with non-invasive ...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.13162
更新日期:2020-06-01 00:00:00
abstract::Epiphyses of man and dog in various stages of union are described. As union approaches, new cartilage is added to the epiphyseal surface of the cartilaginous epiphyseal plate by chondrification of the epiphyseal marrow. Before and during early union the cellular arrangement of the cartilaginous epiphyseal plate is wel...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1975-09-01 00:00:00
abstract::Previous quantitative descriptions of cellular ultrastructure have focused on spatial content (volume, surface area and number of organelles and membrane domains). It is possible to complement such descriptions by also quantifying spatial arrangements. Hitherto, applications of stereological methods for achieving this...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1046/j.1469-7580.1999.19420279.x
更新日期:1999-02-01 00:00:00
abstract::The urethra is the main place of entry for sexually transmitted pathogens. However, there is little literature on the morphology of the urogenital system, principally the urethra and ducts of the sex accessory glands. The Mongolian gerbil is an insectivorous, herbivorous and monogamous rodent with nocturnal habits; it...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1046/j.1469-7580.2003.00181.x
更新日期:2003-05-01 00:00:00
abstract::We present a simple and quick system for accurately scoring the developmental progress of mouse embryos harvested on embryonic day 14 (E14.5). Based solely on the external appearance of the maturing forelimb, we provide a convenient way to distinguish six developmental sub-stages. Using a variety of objective morphome...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12590
更新日期:2017-05-01 00:00:00
abstract::Ceratopsidae represents a group of quadrupedal herbivorous dinosaurs that inhabited western North America and eastern Asia during the Late Cretaceous. Although horns and frills of the cranium are highly variable across species, the lower jaw historically has been considered to be relatively conservative in morphology....
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12374
更新日期:2015-11-01 00:00:00
abstract::This study examined NADPH-d and nNOS expression in the SCG of hamsters. By light microscopy, numerous NADPH-d/NOS positive processes were widely distributed in the ganglion. Ultrastructurally, the NADPH-d reaction product was associated with the membranous organelles of neuronal soma, dendrites, myelinated fibres, sma...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1046/j.1469-7580.2000.19730461.x
更新日期:2000-10-01 00:00:00
abstract::The development of the olfactory epithelium from the 10th day of gestation of postnatal life has been examined electron miscroscopically in the mouse. At 10 days' gestation the epithelium is already differentiated into dark and pale cells, the former representing embryonic stem cells and the latter the developing rece...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1975-07-01 00:00:00
abstract::The neurotropic effect of the distal stump of transected sciatic nerve on regenerating axons emerging from the proximal stump was investigated in rats by the coculture of excised neonatal dorsal root ganglia and segments of degenerated and nondegenerated sciatic nerves. In all cultures, neurites from the ganglion exte...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1995-02-01 00:00:00
abstract::In zoology it is well known that birds are characterized by the presence of feathers, and mammals by hairs. Another common point of view is that avian scales are directly related to reptilian scales. As a skin embryologist, I have been fascinated by the problem of regionalization of skin appendages in amniotes through...
journal_title:Journal of anatomy
pub_type: 杂志文章,评审
doi:10.1111/j.1469-7580.2008.01041.x
更新日期:2009-04-01 00:00:00
abstract::The pulmonary intravascular macrophages (PIMs) of domestic ungulates are recognised by their specific surface coat, consisting of linearly arranged globules along the external leaf of the plasma membrane. The coat is sensitive to in vitro digestion with lipolytic lipase (LPL), intravenous heparin and clinical exposure...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1046/j.1469-7580.2001.19850611.x
更新日期:2001-05-01 00:00:00
abstract::The effect of serum prolactin elevation on the growth and development of the rat breast was investigated. Oral administration of the dopamine antagonist, perphenazine, led to a 5-10-fold elevation of serum prolactin after two days of treatment which was maintained for the 54 days of study. A significant (P less than 0...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1989-02-01 00:00:00
abstract::Apoptosis is an essential physiological process in embryonic development. In the developing eye of vertebrates, three periods of developmental apoptosis can be distinguished: early, intermediate and later. Within the apoptosis pathway, caspases play a crucial role. It has also been shown that HSP110 may have a potenti...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2007.00719.x
更新日期:2007-05-01 00:00:00
abstract::Anatomical specimens used in human or veterinary anatomy laboratories are usually prepared with formaldehyde (a cancerous and teratogenic substance), glycerin (an expensive and viscous fluid), or ethanol (which is flammable). This research aimed to verify the viability of an aqueous 30% sodium chloride solution for pr...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12185
更新日期:2014-07-01 00:00:00
abstract::There is evidence for lymphatic drainage of interstitial fluid from the brain along perivascular spaces in a number of mammalian species. Ultrastructural studies suggest that there are similar drainage pathways in the human cerebral cortex. Perivascular spaces in the basal ganglia, however, differ from those in the co...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1046/j.1469-7580.1997.19130337.x
更新日期:1997-10-01 00:00:00
abstract::Genetic mutation leads to anatomical variation only indirectly because many proteins involved in generating anatomical structures in embryos operate cooperatively within molecular networks. These include gene-regulatory or control networks (CNs) for timing, signaling and patterning together with the process networks (...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12205
更新日期:2014-08-01 00:00:00
abstract::Piecemeal degranulation (PMD) has been recognized in two cases of human pheochromocytoma from the adrenal medulla, which were studied by transmission electron microscopy. Tumour pheochromocytes presented a highly characteristic cytoplasmic admixture of normal resting granules, swollen granules with eroded matrices and...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.0021-8782.2005.00365.x
更新日期:2005-01-01 00:00:00
abstract::This paper reports on the development of a theoretical model to simulate the growth and repair of microdamage in bone. Unlike previous theories, which use simplified descriptions of damage, this approach models each individual microcrack explicitly, and also models the basic multicellular units (BMUs) that repair crac...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1046/j.1469-7580.2003.00194.x
更新日期:2003-08-01 00:00:00
abstract::The blood supply of the symphysis pubis is still the subject of some debate. Classic anatomy books state that this joint is avascular, whereas some published works have shown blood vessels in young specimens. As several articular discs such as the knee menisci are known to have blood vessels in their peripheries, we d...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.0021-8782.2004.00271.x
更新日期:2004-03-01 00:00:00
abstract::In experimental studies addressing the regulation of myelin formation and maintenance by Schwann cells, the sympathetic nervous system of young adult rodents has served a key role as an essentially nonmyelinated yet modifiable control tissue. Nevertheless there is clear evidence of substantial myelination in the super...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1994-04-01 00:00:00
abstract::The present study has shown that the secondary curvature in the cervical spine of the human fetus develops at a much earlier age than has been thought. It may, in fact, develop soon after the embryo first acquires a neck and begins to uncurl. The early appearance of this curvature may be related to the early developme...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1977-07-01 00:00:00
abstract::Light and electron microscopic techniques were employed to study the structure of the ureter of the starling (Sturnus vulgaris). Particular attention was paid to the characterisation of the epithelial cell types. Differences were found in the chemical composition of the mucins found in the ureteric epithelial cells an...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1983-05-01 00:00:00
abstract::Peri-gastrulation stage tammar wallaby embryos were cultured for up to 78 h in either Dulbecco's Modified Eagle's Medium or Medium 199, in air/6% CO(2) or 95% O(2)/5% CO(2), and with added fetal calf or wallaby serum. There was little difference between the two media or sera sources, but development was markedly super...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2007.00846.x
更新日期:2008-02-01 00:00:00