Abstract：
:The aim of the present study was to estimate mean neuronal volume and absolute size distributions of the neocortical neurons in brains from controls and AD patients using stereological methods based on unbiased principles to determine whether changes in absolute cell size are part of the neuropathological pattern of Alzheimer's disease. The neocortex of 8 patients with Alzheimer's disease (AD), mean age 81.1 (68-94) y was compared with 9 nondemented controls, mean age 80.9 (65-101) y. The brains came from Johns Hopkins University Hospital (JHUH) in Baltimore, USA, the Netherlands Brain Bank (NBB), and from a large brain repository in Denmark. The rotator method was used to obtain an estimate of cell volumes providing absolute size distributions of the volume of both cell perikaryon and cell nuclei. The geometric mean volume of cell nuclei in neocortical neurons was 328 microm3 (interindividual CV = 0.15) in the Alzheimer group compared with 277 microm3 (interindividual CV = 0.17) in controls which was a statistically significant increase (P = 0.049). The perikaryal volume was 1117 microm3 in the Alzheimer group compared with 999 microm3 in controls which was a nonsignificant difference (P = 0.20). There was a highly significant correlation between the nuclear and perikaryal volumes in all individuals. The average slope of the regression lines was significantly higher in the Alzheimer patients than in the controls, illustrating that nuclear hypertrophy was more pronounced in the largest neurons.
journal_name
J Anatjournal_title
Journal of anatomyauthors
Bundgaard MJ,Regeur L,Gundersen HJ,Pakkenberg Bdoi
10.1046/j.1469-7580.2001.19840481.xkeywords:
subject
Has Abstractpub_date
2001-04-01 00:00:00pages
481-9issue
Pt 4eissn
0021-8782issn
1469-7580journal_volume
198pub_type
杂志文章abstract：:Enzymatic degradation followed by lectin application was carried out on specimens of the rabbit oviduct. The sequential application of the glycosidases (neuraminidase, alpha-L-fucosidase, beta-galactosidase and alpha-mannosidase) and lectins (peanut, winged pea, wheat germ and soybean) seem promising as an effective m...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1985-06-01 00:00:00
abstract：:The surface coating of the alveolar macrophages and pneumonocytes of hamster lung was studied using an electron microscopy technique. Slices of lung tissue were fixed in aldehyde, labelled with a battery of lectin-horseradish peroxidase conjugates, incubated in a diaminobenzidine-hydrogen peroxide medium and then post...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1986-06-01 00:00:00
abstract：:There is evidence for lymphatic drainage of interstitial fluid from the brain along perivascular spaces in a number of mammalian species. Ultrastructural studies suggest that there are similar drainage pathways in the human cerebral cortex. Perivascular spaces in the basal ganglia, however, differ from those in the co...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.1997.19130337.x
更新日期：1997-10-01 00:00:00
abstract：:The angularis oris gland, an avian salivary gland that lies beneath the zygomatic arch, was studied in the house sparrow by means of light and electron microscopy. The gland consists of lobules composed of epithelial tubules and folds on a delicate connective tissue framework. The lobules are drained by large channels...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1986-04-01 00:00:00
abstract：:The fossil record supports the conclusions derived from the study of extant species that the Primates evolved a unique suite of characters in the articulations of the foot. The tarsal bones of African Miocene apes show specializations characteristic of hominoid evolution and provide reasonable precursors for the morph...
journal_title：Journal of anatomy
pub_type： 历史文章,杂志文章
doi：
更新日期：1980-09-01 00:00:00
abstract：:Proximal femoral morphology and associated musculature are of special relevance to the understanding of hominoid locomotor systems. Knowledge of bone-muscle correspondence in extant hominoids forms an important comparative basis for inferring structure-function relationships in fossil hominids. However, there is still...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12270
更新日期：2015-03-01 00:00:00
abstract：:A morphometric analysis was made of nuclei and cytoplasmic structures in electron micrographs of chondrocytes in the non-calcified layer of articular cartilage of the femoral condyles in adult mouse and dog and of the human incus. Mitochondrial volume density (% cytoplasm) was lower in dog than in mouse cells or cells...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1991-04-01 00:00:00
abstract：:The blood-brain barrier (BBB) is formed by brain endothelial cells lining the cerebral microvasculature, and is an important mechanism for protecting the brain from fluctuations in plasma composition, and from circulating agents such as neurotransmitters and xenobiotics capable of disturbing neural function. The barri...
journal_title：Journal of anatomy
pub_type： 杂志文章,评审
doi：10.1046/j.1469-7580.2002.00064.x
更新日期：2002-06-01 00:00:00
abstract：:The proximal pelvic limb musculature of the Eastern Grey Kangaroo, Macropus giganteus (Zimm) is described with nine illustrations. The text is based on dissections of 44 Grey Kangaroos ranging in empty body weight from 791 g to 58 kg. ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1976-04-01 00:00:00
abstract：:Astyanax brucutu is a peculiar species of Neotropical tetra endemic from the Chapada Diamantina, a large plateau in northeastern Brazil. Individuals of this species undergo a dramatic ontogenetic shift in their diet that is accompanied by equally remarkable changes in their feeding apparatus. Whereas juveniles of A. b...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.13280
更新日期：2020-12-01 00:00:00
abstract：:The histological structure of the oesophagus of the camel in different parts of its course was investigated with tissues from seven camels, and with haematoxylin and eosin and Masson's trichrome stain. Gross dissections confirmed the orientation of the muscle fibres in the tunica muscularis. The epithelium showed heav...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1982-08-01 00:00:00
abstract：:Myocardial hyperplasia is generally considered to occur only during fetal development. However, recent evidence suggests that this type of response may also be triggered by cardiac overload after birth. In congenital heart disease, loading conditions are frequently abnormal, thereby affecting ventricular function. We ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2008.00853.x
更新日期：2008-03-01 00:00:00
abstract：:The role of the neural arch in weight transmission in the cervical and upper thoracic regions of the vertebral column has been investigated. Measurements at the levels of C2, C4, C6, C7, T1 and T5 vertebrae were made in 44 adult male vertebral columns. At each level, the area of the inferior surface of the body was co...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1986-10-01 00:00:00
abstract：:Immunohistochemistry of normal eccrine sweat glands was performed on paraffin sections of human skin. Immunoreactivity (ir) for neuron specific enolase, S100 protein (S100), regulatory peptides, nitric oxide synthase type I (NOS-I) and choline-acetyltransferase (ChAT) was found in small nerve bundles close to sweat gl...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.1999.19430433.x
更新日期：1999-04-01 00:00:00
abstract：:Uptake and translocation of particulates across the mucosal barrier of the gastrointestinal (GI) tract is now generally recognised but the effect of pathophysiologically induced changes on this process is less well established. This study evaluated the effect of diabetes mellitus on GI absorption of particles, compari...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1996-12-01 00:00:00
abstract：:The 2D arrangement of rows of enamel rods with alternating (decussating) tilt angles across the thickness of the inner layer in rat and mouse incisor enamel is well known and assumed to occur in a uniform and repetitive pattern. Some irregularities in the arrangement of rows have been reported, but no detailed investi...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.13053
更新日期：2019-11-01 00:00:00
abstract：:Anatomical specimens used in human or veterinary anatomy laboratories are usually prepared with formaldehyde (a cancerous and teratogenic substance), glycerin (an expensive and viscous fluid), or ethanol (which is flammable). This research aimed to verify the viability of an aqueous 30% sodium chloride solution for pr...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12185
更新日期：2014-07-01 00:00:00
abstract：:The structure of the sinuatrial nodal artery has been investigated in young and old rats. The nodal artery is derived from the internal thoracic artery, runs centrally though the node and supplies it by several branches. An extensive cuff of nodal cells is seen within the adventitia of the artery and its branches adja...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1980-06-01 00:00:00
abstract：:Degeneration, scar formation and regeneration have been studied after section of the optic nerve in the frog. In the normal optic nerve two types of macroglial cell were identified: astrocytes and oligodendroglia. Degeneration after injury proceeded rapidly in comparison with mammals but did not lead to the production...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1981-09-01 00:00:00
abstract：:Retrograde tracers were injected in various parts of the neocortex of the porpoise (Phocoena phocoena). Labelled thalamic neurons were plotted in three-dimensional reconstructions. The lateral geniculate nucleus projects to the visually excitable part of the lateral gyrus. Ventral parts of the medial geniculate nucleu...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1990-04-01 00:00:00
abstract：:Ultrasound of the calcaneus may be used as a cheap, ionising radiation-free and easy to use indicator of skeletal status, and hence of osteoporotic fracture risk. At present ultrasound is not widely used as it suffers from high precision errors. As ultrasound parameters are determined in part by bone mineral density (...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.1998.19330449.x
更新日期：1998-10-01 00:00:00
abstract：:Morphometric analysis of the kidney of the camel was carried out on gross slices and histological sections using standard morphometric methods. The renal cortex occupied about 50% by volume of the kidney, and the ratio of the thickness of the medulla to that of the cortex was about 4:1. The relative thickness of the m...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1979-08-01 00:00:00
abstract：:Surgical interruption of the gastrointestinal tract is widely used for investigating the structure of the enteric nervous system and in the treatment of certain pathological conditions of the gastrointestinal tract. The effects of transection and end-to-end anastomosis and myotomy on nerve cells of the myenteric plexu...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1996-04-01 00:00:00
abstract：:The aim of this study is to quantify and statistically model the age-related decline in the fibrous connective tissue interface of the anterior fontanelle in modern Australian infants, using three-dimensional, semi-automated computed-assisted design protocols. Non-linear regression with variance models, using power fu...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.13200
更新日期：2020-08-01 00:00:00
abstract：:Fertilised chicken eggs were incubated for 48 hours while exposed to pulsed trains of magnetic fields having a duration of 0-5 ms, a rise time of 42 microsecond, and a pulse repetition rate of 100 at a magnetic field flux density of 1 microT. Some eggs were exposed to 1,552 rad X-rays as a positive control. After expo...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1988-04-01 00:00:00
abstract：:The blood supply to the cranial venae cavae on both sides and to the heart was studied macroscopically in 40 adult laboratory shrews (Suncus murinus) of both sexes injected either with Neoprene latex into the abdominal aorta (25 animals) or with Mercox into the left ventricle (15 animals). The 1st branch of the left s...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1993-12-01 00:00:00
abstract：:A series of semen samples from recently fertile men was obtained by masturbation. They were washed and placed in short term culture in BWW medium, and labelled either with tritiated uridine or tritiated tyrosine. Control samples were labelled in the presence of actinomycin D and puromycin respectively, and examined by...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1996-02-01 00:00:00
abstract：:Pulmonary alveolar septa are thought to contain at least two types of fibroblasts that are termed myofibroblasts and lipofibroblasts based on their morphological characteristics. Lipofibroblasts possess cytoplasmic lipid inclusions (lipid bodies or droplets) and are involved in several important functions, such as sur...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12677
更新日期：2017-12-01 00:00:00
abstract：:The musculoskeletal configuration of the mammalian pectoral limb has been heralded as a key anatomical feature leading to the adaptive radiation of mammals, but limb function in the non-mammaliaform cynodont outgroup remains unresolved. Conflicting reconstructions of abducted and adducted posture are based on mutually...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12766
更新日期：2018-03-01 00:00:00
abstract：:The purpose of this study was to examine and describe the sequence of events involved in long-term biological reconstruction of a tendon-bone interface following surgical reattachment. Patellar tendon re-attachment in the adult sheep was used to investigate and describe the biological components involved in healing an...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2007.00699.x
更新日期：2007-03-01 00:00:00
