Abstract：
:Pulmonary alveolar septa are thought to contain at least two types of fibroblasts that are termed myofibroblasts and lipofibroblasts based on their morphological characteristics. Lipofibroblasts possess cytoplasmic lipid inclusions (lipid bodies or droplets) and are involved in several important functions, such as surfactant synthesis, development, vitamin A storage and presumably regeneration. As vitamin A was shown to reduce pulmonary emphysema in several but not all mouse and rat strains, we hypothesized that these strain differences might be explained by a differential occurrence of lipofibroblasts and their lipid bodies in various mouse strains. Therefore, mouse lungs of six strains (NMRI, BALB/c, C3H/HeJ, C57BL/6J, C57BL/6N and FVB/N) were investigated by light and electron microscopic stereology to quantify the amount of lipid bodies and the composition of alveolar septa. Lipofibroblasts were observed qualitatively by transmission electron microscopy in every investigated mouse strain. The total volume and the volume-weighted mean volume of lipid bodies were similar in all mouse strains. The results on the composition of the interalveolar septa did not show major differences between the groups. The only mouse strain that differed significantly from the other strains was the NMRI strain because the lungs had a higher volume and consequently many of the morphological parameters were also larger than in the other groups. In conclusion, the present study showed that lipofibroblasts are a common cell type in the mouse lung across various strains. Therefore, the mere presence or absence of lipofibroblasts does not explain differences in the pulmonary regenerative potential among mouse strains.
journal_name
J Anatjournal_title
Journal of anatomyauthors
Opitz L,Kling KM,Brandenberger C,Mühlfeld Cdoi
10.1111/joa.12677subject
Has Abstractpub_date
2017-12-01 00:00:00pages
970-977issue
6eissn
0021-8782issn
1469-7580journal_volume
231pub_type
杂志文章abstract：:The meaning of the term 'abdomen' has become increasingly ambiguous, as it has to satisfy the contemporary requirements of natural language discourse, literature, gross and radiological anatomy and its role in ontologies supporting electronic records and data modelling. It is critical that there is an agreed understan...
journal_title：Journal of anatomy
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abstract：:A quantitative and morphological study was made of the corpus callosum in children to assess possible sex differences. The shape of the splenium of the corpus callosum was observed to vary between bulbous and cylindrical types with respect to the body of the callosum. The variation was not gender-specific and covariat...
journal_title：Journal of anatomy
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journal_title：Journal of anatomy
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journal_title：Journal of anatomy
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doi：
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journal_title：Journal of anatomy
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journal_title：Journal of anatomy
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journal_title：Journal of anatomy
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doi：
更新日期：1978-09-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1983-06-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章,评审
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更新日期：2009-07-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1993-02-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1994-12-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.2003.00232.x
更新日期：2003-11-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1977-02-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.1997.19040577.x
更新日期：1997-05-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1995-12-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1977-04-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2008.00880.x
更新日期：2008-05-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1111/j.1469-7580.2007.00840.x
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2009.01077.x
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journal_title：Journal of anatomy
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doi：10.1111/j.0021-8782.2004.00337.x
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doi：10.1111/j.1469-7580.2008.00853.x
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journal_title：Journal of anatomy
pub_type： 杂志文章,评审
doi：10.1111/joa.12103
更新日期：2013-11-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
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更新日期：2014-07-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2008.00884.x
更新日期：2008-05-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1990-04-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12708
更新日期：2018-01-01 00:00:00
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journal_title：Journal of anatomy
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doi：
更新日期：1979-09-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
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