Abstract:
:The insulin/insulin-like growth factor (IGF) system regulates fetal and placental growth and development. In maternal diabetes, components of this system including insulin, IGF1, IGF2 and various IGF-binding proteins are deregulated in the maternal or fetal circulation, or in the placenta. The placenta expresses considerable amounts of insulin and IGF1 receptors at distinct locations on both placental surfaces. This makes the insulin and the IGF1 receptor accessible to fetal and/or maternal insulin, IGF1 and IGF2. Unlike the receptor for IGF1, the insulin receptor undergoes a gestational change in expression site from the trophoblast at the beginning of pregnancy to the endothelium at term. Insulin and IGFs are implicated in the receptor-mediated regulation of placental growth and transport, trophoblast invasion and placental angiogenesis. The dysregulation of the growth factors and their receptors may be involved in placental and fetal changes observed in diabetes, i.e. enhanced placental and fetal growth, placental hypervascularization and higher levels of fetal plasma amino acids.
journal_name
J Anatjournal_title
Journal of anatomyauthors
Hiden U,Glitzner E,Hartmann M,Desoye Gdoi
10.1111/j.1469-7580.2008.01035.xsubject
Has Abstractpub_date
2009-07-01 00:00:00pages
60-8issue
1eissn
0021-8782issn
1469-7580pii
JOA1035journal_volume
215pub_type
杂志文章,评审abstract::Forelimb reduction occurred independently in multiple lineages of theropod dinosaurs. Although tyrannosaurs are renowned for their tiny, two-fingered forelimbs, the degree of their reduction in length is surpassed by abelisaurids, which possess an unusual morphology distinct from that of other theropods. The forelimbs...
journal_title:Journal of anatomy
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abstract::At the time of blastocyst implantation the uterine spiral arteries have already undergone morphological changes in the absence of any extravillous trophoblast invasion. Only 2 weeks after implantation, extravillous trophoblast cells develop and come into first contact with decidual tissues. Invading through the decidu...
journal_title:Journal of anatomy
pub_type: 杂志文章,评审
doi:10.1111/j.1469-7580.2008.01036.x
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abstract::The distributing of vimentin and cytokeratin intermediate filaments within the cells of the dental follicle and developing periodontal ligament is described during eruption of the rat 1st molar tooth. Alcohol-fixed tissues from animals ranging from neonates to 12 wk old were cryosectioned, immunolabelled with monoclon...
journal_title:Journal of anatomy
pub_type: 杂志文章
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journal_title:Journal of anatomy
pub_type: 杂志文章
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更新日期:1999-10-01 00:00:00
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journal_title:Journal of anatomy
pub_type: 杂志文章
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journal_title:Journal of anatomy
pub_type: 杂志文章,评审
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journal_title:Journal of anatomy
pub_type: 杂志文章
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更新日期:2017-04-01 00:00:00
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journal_title:Journal of anatomy
pub_type: 杂志文章
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journal_title:Journal of anatomy
pub_type: 杂志文章
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更新日期:1997-10-01 00:00:00
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journal_title:Journal of anatomy
pub_type: 杂志文章
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journal_title:Journal of anatomy
pub_type: 杂志文章
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journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1990-02-01 00:00:00
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journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1982-08-01 00:00:00
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journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1976-02-01 00:00:00
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journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2006.00573.x
更新日期:2006-05-01 00:00:00
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journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1988-02-01 00:00:00
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journal_title:Journal of anatomy
pub_type: 杂志文章
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更新日期:2020-12-01 00:00:00
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journal_title:Journal of anatomy
pub_type: 杂志文章
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更新日期:2010-12-01 00:00:00
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journal_title:Journal of anatomy
pub_type: 杂志文章
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journal_title:Journal of anatomy
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journal_title:Journal of anatomy
pub_type: 杂志文章
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journal_title:Journal of anatomy
pub_type: 杂志文章
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更新日期:2014-08-01 00:00:00
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journal_title:Journal of anatomy
pub_type: 杂志文章
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更新日期:2017-02-01 00:00:00
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journal_title:Journal of anatomy
pub_type: 杂志文章
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更新日期:1978-10-01 00:00:00
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journal_title:Journal of anatomy
pub_type: 杂志文章
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journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1982-08-01 00:00:00
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journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1983-09-01 00:00:00
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journal_title:Journal of anatomy
pub_type: 杂志文章
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