Abstract：
:Distinguishing arteries from veins in vivo has a great significance in clinical practices and preclinical studies. Optical imaging methods such as two-photon microscopy can provide high-resolution morphological information of tissue and are therefore extremely suitable for imaging small blood vessels. However, few optical imaging methods allow in vivo identification of arteries and veins merely utilizing the autofluorescence signal of blood vessels. In this report, we found the arterial wall generates a remarkably stronger two-photon excitation autofluorescence (TPEA) signal compared with the venous wall based on BALB/c mice. According to histological analysis and fluorescence characteristic measurement, the contrast signal is confirmed to be from elastin fibers. Employing this unique feature, we propose an objective and effective artery-vein separation strategy that considers the presence of the elastin-TPEA border as the indicator of arteries. Using this strategy, the arterial and venous networks of the dorsal skin and cerebral cortex of BALB/c mice are demonstrated to be excellently mapped and accurately separated in vivo without depending on any exogenous contrast agent, empirical knowledge, and algorithm. This study may provide a novel technique for mapping arterial and venous networks for anatomic research as well as an extra aid to basic researches on the mechanism, diagnosis, and treatment of blood vessel-related diseases.
journal_name
J Anatjournal_title
Journal of anatomyauthors
Li H,Yan M,Yu J,Xu Q,Xia X,Liao J,Zheng Wdoi
10.1111/joa.13080subject
Has Abstractpub_date
2020-01-01 00:00:00pages
171-179issue
1eissn
0021-8782issn
1469-7580journal_volume
236pub_type
杂志文章abstract：:The angularis oris gland, an avian salivary gland that lies beneath the zygomatic arch, was studied in the house sparrow by means of light and electron microscopy. The gland consists of lobules composed of epithelial tubules and folds on a delicate connective tissue framework. The lobules are drained by large channels...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1986-04-01 00:00:00
abstract：:Androgen deficiency is one of the major factors leading to the development of osteoporosis in men. Since calcitonin (CT) is a potent antiresorptive agent, in the present study we investigated the effects of androgen deficiency and subsequent testosterone and estradiol treatment on CT-producing thyroid C cells, skeleta...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12013
更新日期：2013-03-01 00:00:00
abstract：:The histological structure of the oesophagus of the camel in different parts of its course was investigated with tissues from seven camels, and with haematoxylin and eosin and Masson's trichrome stain. Gross dissections confirmed the orientation of the muscle fibres in the tunica muscularis. The epithelium showed heav...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1982-08-01 00:00:00
abstract：:Epiphyses of man and dog in various stages of union are described. As union approaches, new cartilage is added to the epiphyseal surface of the cartilaginous epiphyseal plate by chondrification of the epiphyseal marrow. Before and during early union the cellular arrangement of the cartilaginous epiphyseal plate is wel...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1975-09-01 00:00:00
abstract：:The insulin/insulin-like growth factor (IGF) system regulates fetal and placental growth and development. In maternal diabetes, components of this system including insulin, IGF1, IGF2 and various IGF-binding proteins are deregulated in the maternal or fetal circulation, or in the placenta. The placenta expresses consi...
journal_title：Journal of anatomy
pub_type： 杂志文章,评审
doi：10.1111/j.1469-7580.2008.01035.x
更新日期：2009-07-01 00:00:00
abstract：:The lungs of 3 small passerine species, having similar body mass but different diurnal activity patterns, were analysed morphometrically to assess the relationship between diurnal activity and pulmonary volumetry at the light and electron microscope levels. The percentage volumes of the major lung and exchange tissue ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.1998.19340573.x
更新日期：1998-11-01 00:00:00
abstract：:Some aspects of normal obliteration of sutures in rabbit and man were studied histologically and it was found that suture closure took place by intramembranous ossification in specific areas of trans-suturally arranged, tendon-like tissue. Histochemically these areas demonstrated high activity of oxidative enzymes. ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1978-02-01 00:00:00
abstract：:Mammalian Langerhans cells (LC) are epidermal dendritic cells which originate in bone marrow and migrate toward the T cell area of lymph nodes, where they act as professional antigen-presenting cells. A variety of cell surface markers, such as the ectoenzyme adenosine triphosphatase (ATPase), Ia and CDla antigens, hav...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.2001.19940493.x
更新日期：2001-10-01 00:00:00
abstract：:The number and topographic distribution of the profiles of degenerating primary afferent fibres were determined within the rat dorsal column 3-4 weeks after division of the lumbar and S2 dorsal roots. The degenerating fibres were identified in toluidine blue-stained 1 micron transverse sections taken at different spin...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1987-08-01 00:00:00
abstract：:The structure of the gonad primordia is described in the embryos of three species of poeciliid fish. Prior to the sexualisation of the germ cells, a dimorphism exists based upon the gonadal somatic features. This serves as a basis for distinguishing between male and female specimens. Presumptive males are characterise...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1985-03-01 00:00:00
abstract：:Peripheral sensory and autonomic neurons are known to possess insulin receptors. These have been considered to be of the peripheral type, i.e. similar to those of hepatic and fat cells rather than of the brain type which show dual specificity for both insulin and insulin-like growth factor (IGF-1). We have examined th...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.1997.19130431.x
更新日期：1997-10-01 00:00:00
abstract：:The formation of a placenta is critical for successful mammalian pregnancy and requires remodelling of the uterine epithelium. In eutherian mammals, remodelling involves specific morphological changes that often correlate with the mode of embryonic attachment. Given the differences between marsupial and eutherian plac...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12610
更新日期：2017-07-01 00:00:00
abstract：:Anomalous connection of the inferior caval vein to the left atrium is exceedingly rare, and has even been considered by some authors an anatomic and embryologic impossibility. This study demonstrates for the first time the existence of this rare malformation, diagnosed on prenatal echo, and confirmed on post-mortem ex...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.13378
更新日期：2020-12-20 00:00:00
abstract：:The evolution of animal morphology can be understood as a series of changes in developmental programs. Among vertebrates, some developmental stages are conserved across species, representing particular developmental constraints. One of the most conserved stages is the vertebrate pharyngula, in which similar embryonic ...
journal_title：Journal of anatomy
pub_type： 杂志文章,评审
doi：10.1111/j.1469-7580.2005.00483.x
更新日期：2005-11-01 00:00:00
abstract：:The extent of neuronal labelling with horseradish peroxidase (HRP) was examined in rat trigeminal motor neurons at various stages of acrylamide intoxication, following HRP uptake by motor nerve endings in the anterior digastric muscle. After 7 days of acrylamide (5 daily injections of 30 mg acrylamide/kg body weight),...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1983-10-01 00:00:00
abstract：:The total number of muscle fibres, as well as the numbers of Type I, Type II and intermediate muscle fibre types, in transverse sections of the pectineus muscles of dogs of 2 and 12 months of age was determined by an indirect fibre counting method. The total nubmers of fibres in all muscles decreased very significantl...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:An electron microscopic study of myelination was carried out in the anterior limb of the anterior commissure of the mouse brain. The total number of axons increased from 48 700 at 17 days post-conception to 286 500 at 11 days postnatum. The first evidence of myelination was the presence of a few promyelin fibres at 8 ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1975-02-01 00:00:00
abstract：:The proposal that the cytoplasmic granules of glomerular peripolar cells (PPCs) of the adult sheep and lamb contain a kallikrein-like substance has been re-examined. After extensive characterisation and purification of anti-kallikrein antibodies, it was concluded that PPCs do not contain immunohistochemically detectab...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1989-02-01 00:00:00
abstract：:Facial size reduction and facial retraction are key features that distinguish modern humans from archaic Homo. In order to more fully understand the emergence of modern human craniofacial form, it is necessary to understand the underlying evolutionary basis for these defining characteristics. Although it is well estab...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2009.01162.x
更新日期：2010-01-01 00:00:00
abstract：:Scales of snakes contain hard proteins (beta-keratins), now referred to as keratin-associated beta-proteins. In the present study we report the isolation, sequencing, and expression of a new group of these proteins from snake epidermis, designated cysteine-glycine-proline-rich proteins. One deduced protein from expres...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2009.01192.x
更新日期：2010-03-01 00:00:00
abstract：:Proper assessment of outcome in clinical trials of neural transplantation requires both biochemical and imaging indices of graft survival, and behavioural and physiological indices of graft function. For transplantation in Huntington's disease, a variety of ligands that are selective for striatal degeneration and graf...
journal_title：Journal of anatomy
pub_type： 杂志文章,评审
doi：10.1046/j.1469-7580.2000.19640597.x
更新日期：2000-05-01 00:00:00
abstract：:The study of human anatomy can be found throughout the rich history of Persia. For thousands of years, morphological descriptions derived from this part of the world have contributed to and have helped form our current anatomical knowledge base. In this article we review the major influential Persian periods and the i...
journal_title：Journal of anatomy
pub_type： 历史文章,杂志文章
doi：10.1111/j.1469-7580.2007.00711.x
更新日期：2007-04-01 00:00:00
abstract：:Although several studies have been published regarding the morphology and anatomical variations of the human shoulder joint, most have dealt with adult individuals. Those looking into the development of the joint have been focused on specific structures or have observed specimens in advanced gestational stages. The go...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12753
更新日期：2018-03-01 00:00:00
abstract：:The distribution of chondrocytes throughout the total thickness of articular cartilage from the femoral condyles of infants, children and adults has been studied using serial sections cut parallel as well as perpendicular to the articular surface. The thickness of the articular cartilage was estimated in fixed section...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1988-04-01 00:00:00
abstract：:Although it is generally assumed that herbivores have more voluminous body cavities due to larger digestive tracts required for the digestion of plant fiber, this concept has not been addressed quantitatively. We estimated the volume of the torso in 126 terrestrial tetrapods (synapsids including basal synapsids and ma...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12557
更新日期：2017-02-01 00:00:00
abstract：:The koala has an inguinoaxillary lymph trunk on either side of the ventral midline, and this carries efferent lymph from the superficial inguinal lymph node directly to the deep axillary lymph node. The superficial lymph nodes are large and soft compared with those of the domestic species, and each lymph centre usuall...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1991-08-01 00:00:00
abstract：:During long bone development the original cartilaginous model in mammals is replaced by bone, but at the long bone endings the avascular articular cartilage remains. Before the articular cartilage attains structural maturity it undergoes reorganization, and molecules such as vascular endothelial growth factor (VEGF) a...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2011.01377.x
更新日期：2011-06-01 00:00:00
abstract：:The developing cortical surfaces of long bones are sculpted and modeled by periosteal osteoclasts and osteoblasts. These surfaces also receive the insertions of tendons and ligaments, and these insertion sites too are modeled to form the root systems that anchor them into the cortical bone. The regulatory molecules th...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12145
更新日期：2014-04-01 00:00:00
abstract：:The meaning of the term 'abdomen' has become increasingly ambiguous, as it has to satisfy the contemporary requirements of natural language discourse, literature, gross and radiological anatomy and its role in ontologies supporting electronic records and data modelling. It is critical that there is an agreed understan...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.13384
更新日期：2021-01-08 00:00:00
abstract：:The neuromuscular junction (NMJ) is the highly specialised peripheral synapse formed between lower motor neuron terminals and muscle fibres. Post-synaptic acetylcholine receptors (AChRs), which are found in high density in the muscle membrane, bind to acetylcholine released into the synaptic cleft of the NMJ, thereby ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.13228
更新日期：2020-10-01 00:00:00
