Abstract：
:Peripheral sensory and autonomic neurons are known to possess insulin receptors. These have been considered to be of the peripheral type, i.e. similar to those of hepatic and fat cells rather than of the brain type which show dual specificity for both insulin and insulin-like growth factor (IGF-1). We have examined the localisation of insulin and IGF-1 receptors in cultured sensory and sympathetic ganglion cells using confocal microscopy and indirect labelling with FITC (fluorescein isothiocyanate) and TRITC (tetramethyl rhodamine isothiocyanate) respectively. We have shown that in cultured U266B1 multiple myeloma cells these receptors display separate localisation, whereas they are colocalised in IM-9 lymphocytes which are known to possess hybrid receptors. We have confirmed the sequestration of insulin and IGF-1 receptors in the cytoplasm of sensory and sympathetic neurons, consistent with a brain-type receptor. The colocalisation of insulin and IGF-1 receptors in sensory and sympathetic ganglion cells is consistent with the view that they are hybrid receptors, similar to those present in the CNS. The function of these receptors, as suggested for the CNS, may be related to trophic support for neurons.
journal_name
J Anatjournal_title
Journal of anatomyauthors
Karagiannis SN,King RH,Thomas PKdoi
10.1046/j.1469-7580.1997.19130431.xsubject
Has Abstractpub_date
1997-10-01 00:00:00pages
431-40eissn
0021-8782issn
1469-7580journal_volume
191 ( Pt 3)pub_type
杂志文章abstract：:Although seen frequently during dissections and autopsies, Hyperostosis frontalis interna (HFI) - a morphological pattern of the frontal bone thickening - is often ignored and its nature and development are not yet understood sufficiently. Current macroscopic classification defines four grades/stages of HFI based on t...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12506
更新日期：2016-11-01 00:00:00
abstract：:This study presents, for the first time, sequences of five beta-keratin cDNAs from turtle epidermis obtained by means of 5'- and 3'-rapid amplification of cDNA ends (RACE) analyses. The deduced amino acid sequences correspond to distinct glycine-proline-serine-tyrosine rich proteins containing 122-174 amino acids. In ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2008.01030.x
更新日期：2009-02-01 00:00:00
abstract：:The posterior orbitofrontal cortex, anterior temporal sensory association areas and the amygdala have a key role in emotional processing and are robustly interconnected. By analogy with the pattern of connections in early processing sensory areas, anterior temporal sensory and polymodal association cortices send prima...
journal_title：Journal of anatomy
pub_type： 杂志文章,评审
doi：10.1111/j.1469-7580.2007.00777.x
更新日期：2007-08-01 00:00:00
abstract：:Wallerian degeneration and dying-back pathology are two well-known cellular pathways capable of regulating the breakdown and loss of axonal and synaptic compartments of neurons in vivo. However, the underlying mechanisms and molecular triggers of these pathways remain elusive. Here, we show that loss of translation el...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2008.01007.x
更新日期：2008-12-01 00:00:00
abstract：:Despite the long-held assumption that olfaction plays a relatively minor role in the behavioral ecology of birds, crown-group avians exhibit marked phylogenetic variation in the size and form of the olfactory apparatus. As part of a larger effort to better understand the role of olfaction and olfactory tissues in the ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.13197
更新日期：2020-08-01 00:00:00
abstract：:The secretory cells of the golden hamster (Mesocricetus auratus) oviductal epithelium on the day of ovulation were observed by light and electron microscopy. In the fimbriae two types of secretory cells were observed: one possessed secretory granules with electron-lucent matrices, prominent protrusions and many electr...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1991-04-01 00:00:00
abstract：:The penile bone and anterior process were made anorganic for scanning electron microscopy. The mature bone has a basal bulb and a long, cylindrical shaft bevelled at its tip to fit under a matching surface on the anterior process, giving rise to a bevelled 'suture'. A rough, resting, Sharpey-fibre bone surface covers ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1977-12-01 00:00:00
abstract：:In stem-cell research a major difficulty is caused by the lack of distinctive features that allow the identification of human mesenchymal stem cells (hMSC). Until now, there has been no specific marker and the most common way to identify hMSC is by their characteristic stem-cell properties: self-replication and differ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2004.00252.x
更新日期：2004-02-01 00:00:00
abstract：:Large perforations of the tympanic membrane were made in groups of guinea-pigs. The mitotic response in the stratified squamous epithelium at the edge of the wound was examined in perforations between 1 and 28 days after injury. Peaks of activity were discovered at 2, 15-16 and 24 days after wounding. It was also foun...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1977-12-01 00:00:00
abstract：:The aim of the present study was to investigate the ultrastructure of secretory cells in the various regions of the goat oviduct during the follicular and luteal phases of the oestrous cycle. During the follicular phase in the fimbriae, the secretory cells contained small secretory granules with electron-dense matrice...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.1999.19540515.x
更新日期：1999-11-01 00:00:00
abstract：:Facial expressions are a critical mode of non-vocal communication for many mammals, particularly non-human primates. Although chimpanzees (Pan troglodytes) have an elaborate repertoire of facial signals, little is known about the facial expression (i.e. mimetic) musculature underlying these movements, especially when ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2006.00523.x
更新日期：2006-02-01 00:00:00
abstract：:Astyanax brucutu is a peculiar species of Neotropical tetra endemic from the Chapada Diamantina, a large plateau in northeastern Brazil. Individuals of this species undergo a dramatic ontogenetic shift in their diet that is accompanied by equally remarkable changes in their feeding apparatus. Whereas juveniles of A. b...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.13280
更新日期：2020-12-01 00:00:00
abstract：:The koala has an inguinoaxillary lymph trunk on either side of the ventral midline, and this carries efferent lymph from the superficial inguinal lymph node directly to the deep axillary lymph node. The superficial lymph nodes are large and soft compared with those of the domestic species, and each lymph centre usuall...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1991-08-01 00:00:00
abstract：:Dentine- and enamel-forming cells secrete matrix in consistent rhythmic phases, resulting in the formation of successive microscopic growth lines inside tooth crowns and roots. Experimental studies of various mammals have proven that these lines are laid down in subdaily, daily (circadian), and multidaily rhythms, but...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.13198
更新日期：2020-08-01 00:00:00
abstract：:The density and distribution of nerve fibres immunoreactive to antisera for PGP 9.5 (general neuronal marker), calcitonin gene related peptide (CGRP) and substance P (SP) (markers for sensory neurons), as well as neuropeptide Y (NPY), vasoactive intestinal peptide (VIP) and tyrosine hydroxylase (TH) (markers for auton...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.1997.19120245.x
更新日期：1997-08-01 00:00:00
abstract：:This pre-embedding electron-immunocytochemical study investigated the localisation of endothelial (type III) and neuronal (type I) isoforms of nitric oxide synthase, substance P, endothelin-1 and 5-hydroxytryptamine in the human middle cerebral artery taken up to 40 h postmortem. To ¿recover' from the anoxic period so...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1996-02-01 00:00:00
abstract：:Advances in X-ray computed tomography (CT) have led to a rise in the use of non-destructive imaging methods in comparative anatomy. Among these is contrast-enhanced CT scanning, which employs chemical stains to visualize soft tissues. Specimens may then be 'digitally dissected', producing detailed, three-dimensional d...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.13007
更新日期：2019-08-01 00:00:00
abstract：:The Harderian gland, its secretory duct and porphyrin content were examined in the mongolian gerbil (Meriones unguiculatus). The gland consisted of tubules lined by a single layer of epithelial cells and a myoepithelial network. The tubule cells were often binucleate and possessed lipid vacuoles in the apical half of ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1983-10-01 00:00:00
abstract：:The innervation of rat intervertebral disc and adjacent ligamentous tissue has been investigated using 2 antibodies, RT97 and anti-calcitonin gene-related peptide. Immunoreactivity to the peptide was found in many fibres throughout the long ligaments around the intervertebral discs and in the periosteum, especially as...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1992-02-01 00:00:00
abstract：:The total numbers of fibres in transverse histological sections of the pterygoid muscles of Lister rats of various ages were counted on enlarged photomicrographic prints. The number in the medial pterygoid of the male doubled between birth and six weeks. This was followed by a decrease of rather more than 10 percent i...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1975-04-01 00:00:00
abstract：:The total number of muscle fibres, as well as the numbers of Type I, Type II and intermediate muscle fibre types, in transverse sections of the pectineus muscles of dogs of 2 and 12 months of age was determined by an indirect fibre counting method. The total nubmers of fibres in all muscles decreased very significantl...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:Atrial and ventricular myocardium from young golden hamsters, 3-6 months of age, was examined under the transmission electron microscope, representative samples from each animal having been stained histochemically for acid phosphatase (AP) by a lead precipitation technique. Our observations indicated that AP positive ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1987-02-01 00:00:00
abstract：:Lactating animals are particularly susceptible to mastitis during the early stages of mammary gland involution following weaning. In this study we compared the phagocytic capacity of cells collected from sheep mammary secretions at different stages of involution. The ability of neutrophils and macrophages to ingest la...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.0021-8782.2002.00104.x
更新日期：2002-11-01 00:00:00
abstract：:Overactivity of the hypothalamic-pituitary-adrenal (HPA) axis characterized by hypercortisolism, adrenal hyperplasia and abnormalities in negative feedback is the most consistently described biological abnormality in melancholic depression. Corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) are the m...
journal_title：Journal of anatomy
pub_type： 杂志文章,评审
doi：10.1111/j.1469-7580.2005.00443.x
更新日期：2005-09-01 00:00:00
abstract：:The pulmonary intravascular macrophages (PIMs) of domestic ungulates are recognised by their specific surface coat, consisting of linearly arranged globules along the external leaf of the plasma membrane. The coat is sensitive to in vitro digestion with lipolytic lipase (LPL), intravenous heparin and clinical exposure...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.2001.19850611.x
更新日期：2001-05-01 00:00:00
abstract：:The quantitative assessment of the lung architecture forms the foundation of many studies on lung development and lung diseases, where parameters such as alveoli number, alveolar size, and septal thickness are quantitatively influenced by developmental or pathological processes. Given the pressing need for robust data...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12773
更新日期：2018-03-01 00:00:00
abstract：:It is unknown whether loading of the lower limbs through additional storage of fat mass as evident in obesity would promote muscular adaptations similar to those seen with resistance exercise. It is also unclear whether ageing modulates any such adjustments. This study aimed to examine the relationships between adipos...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12248
更新日期：2014-12-01 00:00:00
abstract：:In the infant the region lateral to the sella turcica which is traditionally termed the 'cavernous sinus' is composed of 3 individual compartments. The aim of this study was to demonstrate a similar compartmentation of the adult cavernous sinus and to identify and quantify the adipose bodies which are located within t...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.2000.19740681.x
更新日期：2000-11-01 00:00:00
abstract：:Angiogenesis is essential for the replacement of cartilage by bone during growth and repair. In order to obtain a better understanding of the mechanisms regulating vascular invasion at sites of endochondral ossification we have investigated the expression of the endothelial cell-specific mitogen, vascular endothelial ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.1999.19440519.x
更新日期：1999-05-01 00:00:00
abstract：:Data are presented on the postnatal growth of the mouse bladder. Both bladder size (measured as surface area) and bladder wet weight increase steadily with age, respectively reaching 2.5 times and 4 times their newborn values by the age of ten weeks. Despite this growth, which may be due principally to non-urothelial ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1985-12-01 00:00:00
