Abstract:
:We previously identified a pericellular matrix keratan sulphate/chondroitin sulphate proteoglycan present on the surface of human embryonal carcinoma stem cells, cells whose differentiation mimics early development. Antibodies reactive with various epitopes on this molecule define a cluster of differentiation markers for primate pluripotent stem cells. We describe the purification of a form of this molecule which is secreted or shed into the culture medium. Biochemical analysis of the secreted form of this molecule shows that the monomeric form, whilst containing keratan sulphate, resembles mucins in its structure and its modification with O-linked carbohydrate. Immunofluorescence and immunoblotting data show that monkey and human pluripotent stem cells react with antibodies directed against epitopes on either carbohydrate side chains or the protein core of the molecule.
journal_name
J Anatjournal_title
Journal of anatomyauthors
Cooper S,Bennett W,Andrade J,Reubinoff BE,Thomson J,Pera MFdoi
10.1046/j.1469-7580.2002.00034.xkeywords:
subject
Has Abstractpub_date
2002-03-01 00:00:00pages
259-65issue
Pt 3eissn
0021-8782issn
1469-7580journal_volume
200pub_type
杂志文章abstract::Bone growth at the cranial sutures relies on proliferation of osteogenic progenitor cells and/or differentiation of osteoblasts. The current study was undertaken to assess these events in relation to suture growth and fusion. A total of 21 pigs, divided into three age groups (0.5-1.5 months, 3-4 months and 5-7 months)...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2007.00761.x
更新日期:2007-09-01 00:00:00
abstract::Forelimb reduction occurred independently in multiple lineages of theropod dinosaurs. Although tyrannosaurs are renowned for their tiny, two-fingered forelimbs, the degree of their reduction in length is surpassed by abelisaurids, which possess an unusual morphology distinct from that of other theropods. The forelimbs...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12660
更新日期:2017-10-01 00:00:00
abstract::Darwin's finches are a model system in ecological and evolutionary research, but surprisingly little is known about their skull morphology and development. Indeed, only the early beak development and external variation in adult beak shape has been studied. Understanding the development of the skull from embryo up to t...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2011.01388.x
更新日期:2011-08-01 00:00:00
abstract::Neutron diffraction measurements of the orientation of the apatite crystals show a significant preference of their c-axes for the vertical direction. This preference increases from bottom to top of each vertebral body and is substantially greater for the second than for the fifth lumbar vertebrae. This is in line with...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1979-03-01 00:00:00
abstract::The quantitative assessment of the lung architecture forms the foundation of many studies on lung development and lung diseases, where parameters such as alveoli number, alveolar size, and septal thickness are quantitatively influenced by developmental or pathological processes. Given the pressing need for robust data...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12773
更新日期:2018-03-01 00:00:00
abstract::The axolotl Ambystoma mexicanum is one of the most used model organisms in evolutionary, developmental and regenerative studies, particularly because it can reconstitute a fully functional and complete forelimb/hindlimb. Surprisingly, there is no publication that describes all the pectoral and forelimb muscles of this...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2012.01567.x
更新日期:2012-12-01 00:00:00
abstract::Continuous tooth replacement is common for tetrapods, but some groups of acrodont lepidosaurs have lost the ability to replace their dentition (monophyodonty). Acrodonty, where the tooth attaches to the apex of the jawbone, is an unusual form of tooth attachment that has been associated with the highly autapomorphic c...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12754
更新日期:2018-03-01 00:00:00
abstract::Autism Spectrum Disorders (ASDs) are a heterogeneous group of neurodevelopmental disorders that are diagnosed solely on the basis of behaviour. A large body of work has reported neuroanatomical differences between individuals with ASD and neurotypical controls. Despite the huge clinical and genetic heterogeneity that ...
journal_title:Journal of anatomy
pub_type: 杂志文章,评审
doi:10.1111/joa.12542
更新日期:2017-01-01 00:00:00
abstract::Alveolar macrophages were isolated from the lungs of hamsters by lavage and centrifugation. The harvesting procedure yielded about 5.2 X 10(6) cells per animal and the majority of these cells were viable as assessed by a Trypan blue exclusion test. Monolayers of macrophages were labelled with a series of FITC-conjugat...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1985-03-01 00:00:00
abstract::A qualitative study by light and electron microscopy was undertaken on the liver of the brown trout, Salmo trutta fario. Vessels and bile ducts were observed to be scattered without any apparent order within the parenchyma. Venous profiles appeared either isolated or included in 'venous-arteriolar tracts' (VAT) and 'v...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1994-10-01 00:00:00
abstract::The relationship between lung liquid flow and fetal lung development has been studied at the cellular level using ultrastructural techniques. Continuous in utero tracheal ligation and drainage (over a period of 21-28 days) both result in malformations of the developing fetal lamb lung. Ligated lungs are larger, and dr...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1977-07-01 00:00:00
abstract::Neural stem cells are a multipotent population of tissue-specific stem cells with a broad but limited differentiation potential. However, recent studies have shown that over-expression of the pluripotency gene, Oct4, alone is sufficient to initiate a process by which these can form 'induced pluripotent stem cells' (iP...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2010.01269.x
更新日期:2010-09-01 00:00:00
abstract::The mean fibre areas of samples from m. semitendinosus, m. diaphragma and m. pectoralis transversus of thoroughbred horses and greyhounds have been compared with those in similar samples from other members of their species. Athletes (greyhounds and thoroughbreds) have larger fibres in the semitendinosus and diaphragm ...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1978-10-01 00:00:00
abstract::Although the small intestine of the sheep is relatively mature at birth, there are still vacuolated enterocytes present for at least 2 days in distal regions. In the distal regions, vacuolated cells possess a range of vesicle morphology which might be indicative of at least 2 separate routes for enterocyte handling of...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1989-10-01 00:00:00
abstract::It is well accepted that the aortic plexus is a network of pre- and post-ganglionic nerves overlying the abdominal aorta, which is primarily involved with the sympathetic innervation to the mesenteric, pelvic and urogenital organs. Because a comprehensive anatomical description of the aortic plexus and its connections...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12251
更新日期:2015-01-01 00:00:00
abstract::Fertilised chicken eggs were incubated for 48 hours while exposed to pulsed trains of magnetic fields having a duration of 0-5 ms, a rise time of 42 microsecond, and a pulse repetition rate of 100 at a magnetic field flux density of 1 microT. Some eggs were exposed to 1,552 rad X-rays as a positive control. After expo...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1988-04-01 00:00:00
abstract::The present report describes quantitative studies of mitochondria from stratified squamous epithelial cells from hamster cheek pouch mucosa in differentiating compartments. Mucosa was processed for electron microscopy and, using strict sampling procedures, electron micrographs of epithelium from defined basal, spinous...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1983-06-01 00:00:00
abstract::Human beings stand upright with the chain of balance beginning at the feet, progressing to the lower limbs (ankles, knees, hip joints, pelvis), each of the spinal segments, and then ending at the cranium to achieve horizontal gaze and balance using minimum muscle activity. The details of the alignment and balance of t...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12586
更新日期:2017-05-01 00:00:00
abstract::The effects of bacterial lipopolysaccharide (LPS) on the expression of surface antigens including major histocompatibility complex (MHC) and complement type 3 (CR3) receptors on microglial cells in the corpus callosum in postnatal rat brain were investigated. When LPS was injected intravenously (i.v.) in 1-d-old rats,...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1994-04-01 00:00:00
abstract::Electron microscopy has been used to investigate whether the transversely striated columns of the connecting piece in the neck region of guinea pig spermatozoa, undergo lengthening and shortening as a result of the forces generated during motility. Motile spermatozoa were subjected to near-instantaneous rapid freezing...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2008.00919.x
更新日期:2008-09-01 00:00:00
abstract::Adult male Sprague-Dawley rats were randomly assigned to two groups: control and anaemic. Anaemia was induced by periodical blood withdrawal. Extensor digitorum longus and soleus muscles were excised under pentobarbital sodium total anaesthesia and processed for transmission electron microscopy, histochemical and bioc...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2008.00908.x
更新日期:2008-06-01 00:00:00
abstract::The aims of the present study were to determine whether nerves that contain nitric oxide synthase (NOS), calcitonin gene-related peptide (CGRP) or substance P (SP) are present in the human vagina and, if so, to determine the pattern of innervation relative to that of other neurotransmitters, particularly vasoactive in...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1996-06-01 00:00:00
abstract::The meaning of the term 'abdomen' has become increasingly ambiguous, as it has to satisfy the contemporary requirements of natural language discourse, literature, gross and radiological anatomy and its role in ontologies supporting electronic records and data modelling. It is critical that there is an agreed understan...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.13384
更新日期:2021-01-08 00:00:00
abstract::This study reports the tissue distribution of Hepatocyte Growth Factor-Scatter Factor (HGF/SF) in human fetal tissue using Northern analysis and in situ hybridisation techniques. In tissue from fetuses of 9-17 wk gestational age, the 6 kb mRNA transcript for HGF/SF was demonstrated in many tissues but prominently in l...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1994-12-01 00:00:00
abstract::There is a limited understanding of the normal function of the pterygoïdeus proprius muscle and the role that this muscle may have in temporomandibular disorders. Despite a well-described anatomical in-vitro approach to this muscle, there are still difficulties in investigating the fossa pterygopalatina. This study re...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2010.01308.x
更新日期:2010-12-01 00:00:00
abstract::Diaphragmatic sulci in the superior surface of the liver were found in 40% of cases at autopsy. All sulci were located in the right lobe and in 47% they were multiple. In order to evaluate possible predisposing factors for these accessory sulci, their topography and characteristics were observed in unfixed livers; mor...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1046/j.1469-7580.2003.00160.x
更新日期:2003-03-01 00:00:00
abstract::Wallerian degeneration and dying-back pathology are two well-known cellular pathways capable of regulating the breakdown and loss of axonal and synaptic compartments of neurons in vivo. However, the underlying mechanisms and molecular triggers of these pathways remain elusive. Here, we show that loss of translation el...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2008.01007.x
更新日期:2008-12-01 00:00:00
abstract::The fine structure of the intercellular junctions of the hen parathyroid gland was studied using freeze-fracture replicas and thin sections. In the conventional thin sections, desmosomes, intermediate junctions (maculae adherentes) and gap junctions were observed, and in the lanthanum-fixed sections, tight junctions (...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1982-09-01 00:00:00
abstract::Mechanisms for passively coordinating forelimb movements and flight feather abduction and adduction have been described separately from both in vivo and ex vivo studies. Skeletal coordination has been identified as a way for birds to simplify the neuromotor task of controlling flight stroke, but an understanding of th...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12511
更新日期:2016-11-01 00:00:00
abstract::At the time of blastocyst implantation the uterine spiral arteries have already undergone morphological changes in the absence of any extravillous trophoblast invasion. Only 2 weeks after implantation, extravillous trophoblast cells develop and come into first contact with decidual tissues. Invading through the decidu...
journal_title:Journal of anatomy
pub_type: 杂志文章,评审
doi:10.1111/j.1469-7580.2008.01036.x
更新日期:2009-07-01 00:00:00