Biochemical properties of a keratan sulphate/chondroitin sulphate proteoglycan expressed in primate pluripotent stem cells.

Abstract:

:We previously identified a pericellular matrix keratan sulphate/chondroitin sulphate proteoglycan present on the surface of human embryonal carcinoma stem cells, cells whose differentiation mimics early development. Antibodies reactive with various epitopes on this molecule define a cluster of differentiation markers for primate pluripotent stem cells. We describe the purification of a form of this molecule which is secreted or shed into the culture medium. Biochemical analysis of the secreted form of this molecule shows that the monomeric form, whilst containing keratan sulphate, resembles mucins in its structure and its modification with O-linked carbohydrate. Immunofluorescence and immunoblotting data show that monkey and human pluripotent stem cells react with antibodies directed against epitopes on either carbohydrate side chains or the protein core of the molecule.

journal_name

J Anat

journal_title

Journal of anatomy

authors

Cooper S,Bennett W,Andrade J,Reubinoff BE,Thomson J,Pera MF

doi

10.1046/j.1469-7580.2002.00034.x

keywords:

subject

Has Abstract

pub_date

2002-03-01 00:00:00

pages

259-65

issue

Pt 3

eissn

0021-8782

issn

1469-7580

journal_volume

200

pub_type

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