Abstract:
:The blood-brain barrier (BBB) is formed by brain endothelial cells lining the cerebral microvasculature, and is an important mechanism for protecting the brain from fluctuations in plasma composition, and from circulating agents such as neurotransmitters and xenobiotics capable of disturbing neural function. The barrier also plays an important role in the homeostatic regulation of the brain microenvironment necessary for the stable and co-ordinated activity of neurones. The BBB phenotype develops under the influence of associated brain cells, especially astrocytic glia, and consists of more complex tight junctions than in other capillary endothelia, and a number of specific transport and enzyme systems which regulate molecular traffic across the endothelial cells. Transporters characteristic of the BBB phenotype include both uptake mechanisms (e.g. GLUT-1 glucose carrier, L1 amino acid transporter) and efflux transporters (e.g. P-glycoprotein). In addition to a role in long-term barrier induction and maintenance, astrocytes and other cells can release chemical factors that modulate endothelial permeability over a time-scale of seconds to minutes. Cell culture models, both primary and cell lines, have been used to investigate aspects of barrier induction and modulation. Conditioned medium taken from growing glial cells can reproduce some of the inductive effects, evidence for involvement of diffusible factors. However, for some features of endothelial differentiation and induction, the extracellular matrix plays an important role. Several candidate molecules have been identified, capable of mimicking aspects of glial-mediated barrier induction of brain endothelium; these include TGFbeta, GDNF, bFGF, IL-6 and steroids. In addition, factors secreted by brain endothelial cells including leukaemia inhibitory factor (LIF) have been shown to induce astrocytic differentiation. Thus endothelium and astrocytes are involved in two-way induction. Short-term modulation of brain endothelial permeability has been shown for a number of small chemical mediators produced by astrocytes and other nearby cell types. It is clear that endothelial cells are involved in both long- and short-term chemical communication with neighbouring cells, with the perivascular end feet of astrocytes being of particular importance. The role of barrier induction and modulation in normal physiology and in pathology is discussed.
journal_name
J Anatjournal_title
Journal of anatomyauthors
Abbott NJdoi
10.1046/j.1469-7580.2002.00064.xkeywords:
subject
Has Abstractpub_date
2002-06-01 00:00:00pages
629-38issue
6eissn
0021-8782issn
1469-7580journal_volume
200pub_type
杂志文章,评审abstract::Data are presented on the postnatal growth of the mouse bladder. Both bladder size (measured as surface area) and bladder wet weight increase steadily with age, respectively reaching 2.5 times and 4 times their newborn values by the age of ten weeks. Despite this growth, which may be due principally to non-urothelial ...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1985-12-01 00:00:00
abstract::This investigation is based upon the pineal organs of 92 specimens of 36 species of the family Pteropodidae (Mammalia, Chiroptera). The size of the megachiropteran pineal correlates well with body size (r = 0.864), confirming the former conclusions that generally larger bodied bats have larger pineals. The range of th...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1990-02-01 00:00:00
abstract::Angiogenesis is essential for the replacement of cartilage by bone during growth and repair. In order to obtain a better understanding of the mechanisms regulating vascular invasion at sites of endochondral ossification we have investigated the expression of the endothelial cell-specific mitogen, vascular endothelial ...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1046/j.1469-7580.1999.19440519.x
更新日期:1999-05-01 00:00:00
abstract::A study has been made of the distribution of granulated metrial gland cells in the non-pregnant uterus, in the pre-implantation uterus and in the post-implantation interconceptual uterus of pregnant albino mice. Granulated cells were only rarely seen in the non-pregnant uterus. In the pre-implantation uterus, they wer...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1981-12-01 00:00:00
abstract::The occipital squama of the Japanese musk shrew, Suncus murinus, consists only of membrane bone which arises from the periosteal bony band of the supraoccipital cartilage. No cartilaginous tectum posterius, generally forming the dorsal border to the foramen magnum, was found in the developing chondrocranium. Also addi...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1994-10-01 00:00:00
abstract::Myocardial hyperplasia is generally considered to occur only during fetal development. However, recent evidence suggests that this type of response may also be triggered by cardiac overload after birth. In congenital heart disease, loading conditions are frequently abnormal, thereby affecting ventricular function. We ...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2008.00853.x
更新日期:2008-03-01 00:00:00
abstract::The present report describes quantitative studies of mitochondria from stratified squamous epithelial cells from hamster cheek pouch mucosa in differentiating compartments. Mucosa was processed for electron microscopy and, using strict sampling procedures, electron micrographs of epithelium from defined basal, spinous...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1983-06-01 00:00:00
abstract::The pituitary of roach, Rutilus rutilus (L.), is pear-shaped and situated in the sella turcica. It is characterised by a large pars nervosa, which penetrates deep into the other regions, splitting the proximal pars distalis. Spatial localisation of nerve fibre types and glandular cell types occurs. Using a variety of ...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1980-06-01 00:00:00
abstract::Langerhans cells of the epidermis of 6-month-old white crossbred farm pigs were identified by electron microscopy. Ultrastructurally they were similar to those described in other mammals. They were present in basal and suprabasal layers and were characterised by a lobulated nucleus and an electrolucent cytoplasm with ...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1991-12-01 00:00:00
abstract::Lactating animals are particularly susceptible to mastitis during the early stages of mammary gland involution following weaning. In this study we compared the phagocytic capacity of cells collected from sheep mammary secretions at different stages of involution. The ability of neutrophils and macrophages to ingest la...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1046/j.0021-8782.2002.00104.x
更新日期:2002-11-01 00:00:00
abstract::An autoradiographic study of neuronal and glial production was carried out in the indusium griseum of mice. Most neurons were produced between 13 and 15 days post-conception. One part of the glial population underwent its last or second-last divisions between 14 and 16 days post-conception, while the other continued t...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1978-05-01 00:00:00
abstract::Most of Mesozoic bird diversity comprises species that are part of one of two major lineages, namely Ornithurae, including living birds, and Enantiornithes, a major radiation traditionally referred to as 'opposite birds'. Here we report the largest Early Cretaceous enantiornithine bird from north-east China, which pro...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2008.00880.x
更新日期:2008-05-01 00:00:00
abstract::The aortic plexus is a network of sympathetic nerves positioned along the infrarenal abdominal aorta. Recently, we characterized the aortic plexus and its ganglia (inferior mesenteric, left/right spermatic, and prehypogastric ganglion) in males; however, the literature minimally describes its anatomy in females. In th...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12436
更新日期:2016-05-01 00:00:00
abstract::The dogma that cutaneous wound healing is impaired as a function of age is largely unsubstantiated. This can be attributed to poor experimental design of human studies, the lack of subject characterisation with the exclusion of disease processes, and the study of inappropriate animal models. Structural and functional ...
journal_title:Journal of anatomy
pub_type: 杂志文章,评审
doi:
更新日期:1995-08-01 00:00:00
abstract::In embryology, the infracardiac bursa (ICB) is a well-known derivative separated from the omental bursa. During surgeries around the esophagogastric junction (EGJ), surgeons often encounter a closed space considered to be equivalent to the ICB, but the macroscopic anatomy in adults is hardly known. This study aimed to...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12989
更新日期:2019-07-01 00:00:00
abstract::The development of pneumatisation in the postcranial skeleton has been investigated in a flock of Golden Comet pullets from hatching to 182 days posthatching. The timing of development of pneumatisation in the vertebral column, vertebral ribs, sternum and humerus has been demonstrated. No pneumatisation was encountere...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1984-08-01 00:00:00
abstract::The spatiotemporal distribution of macrophages in the uterine wall of mice in the second half of pregnancy and the early postpartum period has been studied. Macrophages were identified using a combination of morphological criteria, the capacity to endocytose horseradish peroxidase and the expression of the Mac-1 antig...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1992-08-01 00:00:00
abstract::Serial thin sections of the coronal dental pulp of the cat's canine tooth were cut. Parts of the sub-odontoblastic neural plexus were photographed from 100 of the sections. The plexus consists of many slender, predominantly unmyelinated nerve fibres. Many axons are incompletely sheathed by their Schwann cell. Some axo...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1980-05-01 00:00:00
abstract::The neuromuscular junction (NMJ) is the highly specialised peripheral synapse formed between lower motor neuron terminals and muscle fibres. Post-synaptic acetylcholine receptors (AChRs), which are found in high density in the muscle membrane, bind to acetylcholine released into the synaptic cleft of the NMJ, thereby ...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.13228
更新日期:2020-10-01 00:00:00
abstract::This review describes the progress made in preparing Cochrane systematic reviews of randomized controlled trials for Guillain-Barré syndrome (GBS), chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), multifocal motor neuropathy (MMN) and the demyelinating neuropathies associated with paraproteins. The di...
journal_title:Journal of anatomy
pub_type: 杂志文章,评审
doi:10.1046/j.1469-7580.2002.00041.x
更新日期:2002-04-01 00:00:00
abstract::Blood flow to the pancreatic islets of the anaesthetised rat was measured using the microsphere method. Basal flow was 29 (+/- 6) microliter/min per pancreas which was equivalent to 2.1 (+/- 0.2)% of the total pancreatic flow. The intravenous administration of 4 IU of soluble insulin, which rendered the animals hypogl...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1989-04-01 00:00:00
abstract::Ceratopsidae represents a group of quadrupedal herbivorous dinosaurs that inhabited western North America and eastern Asia during the Late Cretaceous. Although horns and frills of the cranium are highly variable across species, the lower jaw historically has been considered to be relatively conservative in morphology....
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12374
更新日期:2015-11-01 00:00:00
abstract::This study describes at the ultrastructural level the neuronal changes in the intracardiac ganglia of the monkey (Macaca fascicularis) following unilateral vagotomy. One day after unilateral vagotomy, some intracardiac neurons showed an overall increase in electron density, with the dendrites darkening first. At three...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1984-01-01 00:00:00
abstract::Little is known about the embryonic development and variation of the chondrocranium in Crocodylia and there are no works on any Caiman species. Due to the importance of cranial features in the systematics of this clade, investigating the development of the skull in embryonic stages is essential. In this study, we pres...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12968
更新日期:2019-06-01 00:00:00
abstract::The ultrastructure of 3 fibrocartilages is described at the insertion of the adult rat Achilles tendon. Enthesial fibrocartilage lies at the tendon-bone junction, sesamoid fibrocartilage in the deep surface of the tendon where it presses on the calcaneus, and periosteal fibrocartilage covers the opposing surface of th...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1996-08-01 00:00:00
abstract::The relationship between lung liquid flow and fetal lung development has been studied at the cellular level using ultrastructural techniques. Continuous in utero tracheal ligation and drainage (over a period of 21-28 days) both result in malformations of the developing fetal lamb lung. Ligated lungs are larger, and dr...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1977-07-01 00:00:00
abstract::The sacroiliac joint (SIJ) is a well-known source of low back and pelvic pain, of increasing interest for both conservative and surgical treatment. Alterations in the kinematics of the pelvis have been hypothesized as a major cause of SIJ-related pain. However, definitions of both the range and the extent of physiolog...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12924
更新日期:2019-03-01 00:00:00
abstract::Tongues were removed from rat fetuses on d 16 of gestation (E16) and from newborn (P0) and juvenile rats on d 7 (P7) and d 21 (P21) postnatally for examination by light and transmission electron microscopy. In the fetuses at E16, no rudiments of filiform papillae were visible on the dorsal surface of the tongue. No ev...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1046/j.1469-7580.1999.19510027.x
更新日期:1999-07-01 00:00:00
abstract::The ultrastructure of the tammar placenta was studied throughout pregnancy. The uterine epithelium grows from a columnar to an enlarged, undulating epithelium between early gestation and mid-gestation when the shell coat that surrounds the marsupial conceptus ruptures. Trophectoderm and uterine epithelium do not form ...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1046/j.1469-7580.2002.00084.x
更新日期:2002-08-01 00:00:00
abstract::Bone formation occurred ten days after transplantation of guinea-pig urinary bladder wall to the anterior abdominal wall. A quantitative analysis showed that the bone which formed in the tissues of the transplant site grew rapidly during the following week. Thereafter, bone growth slowed and remodelling became evident...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1982-08-01 00:00:00